10-Hydroxycamptothecin
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10-Hydroxycamptothecin 속성
- 녹는점
- 230-237°C
- 끓는 점
- 820.7±65.0 °C(Predicted)
- 밀도
- 1.60
- 저장 조건
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 용해도
- DMSO: ≥ 37.5 mg/mL (102.92 mM)
- 산도 계수 (pKa)
- 8.93±0.40(Predicted)
- 물리적 상태
- 담황색 분말
- 색상
- 노란색
- InChI
- InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3
- InChIKey
- LCZZWLIDINBPRC-FQEVSTJZSA-N
- SMILES
- N1C2C(=CC(O)=CC=2)C=C2CN3C(C=12)=CC1C(CC)(O)C(=O)OCC=1C3=O
- CAS 데이터베이스
- 64439-81-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38-25 | ||
| 안전지침서 | 26-36-45 | ||
| 유엔번호(UN No.) | UN 2811 6.1 / PGIII | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | UQ0491000 |
| 그림문자(GHS): |
 
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| 신호 어: | Danger | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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10-Hydroxycamptothecin C화학적 특성, 용도, 생산
개요
10-Hydroxycamptothecin: An Inhibitor of Topoisomerase I with Antitumor Activity10-hydroxycamptothecin (10-HCPT) is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. 10-HCPT, a member of the camptothecin family, interferes with DNA synthesis by inhibiting the enzyme topoisomerase-I and has a broad spectrum of antitumor activity and less toxicity as camptothecins. However, 10-HCPT is insoluble in both water and physiological acceptable organic solvents and tends to change into its carboxylate form, which shows minimal antitumor activity and several unpredictable side effects. Therefore, appropriate drug delivery systems (DDS) for 10-HPCT have been developed to improve the stability of its lactone form. 10-HCPT is also an important precursor for the synthesis of clinically useful anticancer agents, such as irinotecan[1].
화학적 성질
mp 268-270°C loss on drying <1%용도
Topoisomerase inhibitor참고 문헌
[1] Chunjian Zhao. “Determination of Camptothecin and 10-Hydroxycamptothecin in Camptotheca acuminata by LC-ESI-MS/MS.” Analytical Letters 6 1 (2010): 2681–2693.[2] Ruonan Shuang. “Pharmacokinetics of 10-hydroxycamptothecin–tetrandrine liposome complexes in rat by a simple and sensitive ultra-high performance liquid chromatography with tandem mass spectrometry.” Journal of separation science 43 3 (2019): 569–576.
10-Hydroxycamptothecin 준비 용품 및 원자재
원자재
준비 용품
10-Hydroxycamptothecin 공급 업체
글로벌( 286)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| SICHUAN XIELI PHARMACEUTICAL CO.,LTD. | +86-028-60118998 +8615830127659 |
info@xielipharm.com | China | 24 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 |
abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 |
sales@hbmojin.com | China | 12577 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 997 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3692 | 58 |
| Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 |
sales8@hbganmiao.com | China | 300 | 58 |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 |
sales@sjar-tech.com | China | 485 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 |
sales@capot.com | China | 29733 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29855 | 58 |
| Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 |
yklbiotech@163.com | CHINA | 296 | 58 |
10-Hydroxycamptothecin 관련 검색:
10-하이드록시캠토테신 루르토테칸 엑사테칸 Camtobell염산염 캄프토테신,[(G)3H] SN-38글루쿠로나이드 (S)-9-(4-메틸-1-피페라지닐)메틸-10-하이드록시캄프토테신
10-Hydroxycamptothecin
(+)-Camptothecin
7-Ethyl-10-hydroxycamptothecin
Hydroxyl camptothecine
RUBITECAN
Topotecan
Topotecan hydrochloride
Irinotecan hydrochloride
IRINOTECAN-D10 HYDROCHLORIDE
10-Hydroxycamptothecin
10-METHOXYCAMPTOTHECIN