アミトリプチリン 塩酸塩 化学特性,用途語,生産方法
外観
白色～わずかにうすい褐色, 結晶性粉末～粉末
溶解性
水、エタノール及びアセトンに溶ける。
用途
薬理研究用。
効能
抗うつ薬
商品名
アミトリプチリン塩酸塩 (沢井製薬); トリプタノール (日医工)
説明
Amitriptyline (hydrochloride) (CRM) (Item No. 19031) is a certified reference material categorized as a tricyclic antidepressant. This product is intended for analytical forensic applications. This product is also available as a general research tool .
化学的特性
White to Off-White Solid
使用
Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors.
一般的な説明
Amitriptyline, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride,5-(3-dimethylaminopropylidene)-10,11-dihydro-5Hdibenzo[a,d]cycloheptene hydrochloride (Elavil), is one ofthe most anticholinergic and sedative of the TCAs. Becauseit lacks the ring-electron–enriching nitrogen atom ofimipramine, metabolic inactivation mainly proceeds not at theanalogous 2-position but at the benzylic 10-position (i.e.,toluene-like metabolism predominates). Because of the 5-exocyclic double bond, E- and Z-hydroxy isomers are producedby oxidation metabolism. Conjugation produces excretablemetabolites. As is typical of the dimethyl compounds,N-demethylation occurs, and nortriptyline is produced, whichhas a less anticholinergic, less sedative, and more stimulantaction than amitriptyline. Nortriptyline is a SNERI; thecomposite action of drug and metabolite is nonselective.
安全性プロファイル
Poison by ingestion,
intraperitoneal, intravenous, and
subcutaneous routes. Human systemic
effects by ingestion: convulsions, respiratory
depression, changes in sleep, hallucinations,
muscle contractions, somnolence, blood
pressure decrease, coma, cyanosis, dyspnea,
and ataxia. An experimental teratogen.
Other experimental reproductive effects.
Mutation data reported. Used in the
treatment of depression. When heated to
decomposition it emits very toxic fumes of
HCl and NOx. See also ELAVIL.
アミトリプチリン 塩酸塩 上流と下流の製品情報
原材料
準備製品