イソオキサゾール 化学特性,用途語,生産方法
外観
無色～うすい黄色、液体
解説
イソオキサゾール弱塩基性でピリジン様の臭気をもつ液体．沸点95 ℃．
森北出版「化学辞典（第2版）
製造
イソオキサゾール,オキサゾールの異性体．プロピオールアルデヒドにヒドロキシルアミンを作用させると得られる.
説明
Isoxazole, an important class of heterocycles, is a five membered heterocyclic compound that exhibits various pharmacological actions. It is present in some natural products such as ibotenic acid and is also used as a foundation for several drugs such as the COX-2 inhibitor valdecoxib and anti-inflammatory drugs. Isoxazoles are largely applied in the area of pharmaceuticals and therapeutics, including insecticidal, antibacterial, antibiotic, antitumour, antifungal, antituberculosis, anticancer and ulcerogenic. Besides, it has a great effect on reducing blood glucose, eliminating pain, resisting inflammation, killing harmful bacteria, controlling and reducing the risk of HIV.
化学的特性
A colorless liquid resembling pyridine. It is soluble in water at room temperature up to six times its volume.
使用
Natural insecticide.
製造方法
Isoxazoles can be synthesized by various methods, such as the 1,3-dipolar cycloaddition reaction of nitrile oxides with alkynes, the reaction of hydroxylamine with 1,3-diketones or propiolic acid derivatives, etc.
www.organic-chemistry.org
定義
ChEBI: Isoxazole is a monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles. It is a mancude organic heteromonocyclic parent, a monocyclic heteroarene and a member of isoxazoles.
一般的な説明
Isoxazole(288-14-2) are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter.
危険性
Narcotic and psychomimetic effects.
参考文献
https://en.wikipedia.org/wiki/Isoxazole
https://pubchem.ncbi.nlm.nih.gov/compound/9254
イソオキサゾール 上流と下流の製品情報
原材料
準備製品