Chinese english Germany Korea

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547)

化学構造式
741713-40-6
CAS番号.
741713-40-6
化学名:
别名:
英語名:
[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547)
英語别名:
R547;CS-238;Ro 4584820;R547 ，S2688;R547(Ro 4584820);R547 >=98% (HPLC);R547, 10 mM in DMSO;R547 Ro-4584820 R-547;3-difluoro-6-Methoxyphenyl)-;[4-aMino-2-[[1-(Methylsulfonyl)-4-piperidinyl]aMino]-5-pyriMidinyl](2
CBNumber:
CB41562444
化学式:
C18H21F2N5O4S
分子量:
441.45
MOL File:
741713-40-6.mol

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) 物理性質

沸点 :
703.7±70.0 °C(Predicted)
比重(密度) :
1.49
貯蔵温度 :
Store at -20°C
溶解性:
Soluble in DMSO
外見 :
crystalline solid
酸解離定数(Pka):
4.22±0.10(Predicted)
色:
White to off-white
InChI:
InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24)
InChIKey:
JRNJNYBQQYBCLE-UHFFFAOYSA-N
SMILES:
C(C1=CN=C(NC2CCN(S(C)(=O)=O)CC2)N=C1N)(C1=C(OC)C=CC(F)=C1F)=O

安全性情報

WGK Germany  WGK 3
ストレージクラス 11 - Combustible Solids

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) 価格 もっと(1)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQK-4820
R547 		741713-40-6 100mg ￥1440000 2024-03-01 購入

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) 化学特性,用途語,生産方法

説明

Cyclin-dependent kinases (Cdks) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. R547 is a diaminopyrimidine compound that inhibits Cdk1/cyclin B, Cdk2/cyclin E, and Cdk4/cyclin D1 (Kis = 1-3 nM). It is inactive against a panel of more than 120 unrelated kinases (Kis > 5 μM). R547 inhibits tumor cell proliferation (IC50s ≤ 0.6 μM in vitro), inducing cell cycle arrest at G1 and G2 phases and apoptosis as well as reducing phosphorylation of the retinoblastoma protein. It also demonstrates antitumor activity in vivo in various human tumor xenograft models.

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) 上流と下流の製品情報

原材料

準備製品

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) 生産企業

Global( 131)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
CONIER CHEM AND PHARMA LIMITED
sales@conier.com China 49906 58
career henan chemical co 		+86-0371-86658258
factory@coreychem.com China 29780 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000
 marketing@targetmol.com United States 32431 58
Dideu Industries Group Limited 		+8617392712697
 1022@dideu.com China 29091 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471
sales@sarms4muscle.com China 10378 58
TargetMol Chemicals Inc. 		+1-781-999-5354;
support@targetmol.com United States 38999 58
Zhengzhou Anbu Chem Co.,Ltd 		+86-0371-88006763; +86-15988602810
 sales@anbuchem.com China 5812 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +86-15965530500
 nickzhang@hangyubiotech.com China 9930 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329
 market18@leapchem.com China 43303 58
Aladdin Scientific
tp@aladdinsci.com United States 54746 58

  スペクトルデータ(1HNMR)

[4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547)(741713-40-6)1HNMR

741713-40-6()キーワード:

スルファニルアミド セルメチニブ イデラリシブ ジナシクリブ (-)-ラパマイシン メタンスルホン酸N-[5-[(4-エチル-1-ピペラジニル)メチル]-2-ピリジニル]-5-フルオロ-4-[4-フルオロ-2-メチル-1-(1-メチルエチル)-1H-ベンズイミダゾール-6-イル]-2-ピリミジンアミン 5-(3-フルオロベンジル)-2,4-ピリミジンジアミン 2-(イソプロピルアミノ)ピリミジン-5-カルブアルデヒド 2'-フルオロ-6'-ヒドロキシアセトフェノン 2,3-ジフルオロ-6-メトキシベンズアルデヒド 1-(2-フルオロ-6-メトキシフェニル)エタノン
  • 741713-40-6
  • [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547)
  • [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone
  • Ro 4584820
  • [4-aMino-2-[[1-(Methylsulfonyl)-4-piperidinyl]aMino]-5-pyriMidinyl](2
  • 3-difluoro-6-Methoxyphenyl)-
  • R547(Ro 4584820)
  • 5-[(2,3-difluoro-6-Methoxyphenyl)carbonyl]-2-N-(1-Methanesulfonylpiperidin-4-yl)pyriMidine-2,4-diaMine
  • (4-Amino-2-{[1-(methylsulfonyl)-4-piperidinyl]amino}-5-pyrimidinyl)(2,3-difluoro-6-methoxyphenyl)methanone
  • (4-Amino-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphen
  • CS-238
  • Methanone, [4-amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)-
  • R547 >=98% (HPLC)
  • [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone(R 547) USP/EP/BP
  • R547 Ro-4584820 R-547
  • R547, 10 mM in DMSO
  • R547 ，S2688
  • R547
Copyright 2017 © ChemicalBook. All rights reserved