メトラゾール 化学特性,用途語,生産方法
解説
メトラゾールは，カルジアゾール，ペンテトラゾールともいう。シクロヘキサノンからつくる。無色の単斜針状の結晶で，水，有機溶剤によく溶ける。中枢興奮薬剤に用いられた。ブリタニカ国際大百科事典 小項目事典 ブリタニカ
効能
呼吸促進薬
説明
Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals. Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures. PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABA
A receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABA
A receptor.
化学的特性
white crystalline powder
使用
Non-specific CNS stimulant; convulsant; narcotic antagonist.
定義
ChEBI: An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other
espiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
一般的な説明
White crystalline powder or granular solid with a slightly pungent odor. Bitter taste. Aqueous solutions neutral to litmus.
空気と水の反応
Dust can be explosive when suspended in air at specific concentrations. Water soluble.
反応プロフィール
Pentetrazol is incompatible with oxidizing agents. . Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. Azo dyes can be explosive when suspended in air at specific concentrations.
火災危険
Flash point data for Pentetrazol are not available. Pentetrazol is probably combustible.
生物活性
CNS stimulant that induces kindling in vivo . Causes alterations in excitatory and inhibitory neurotransmitter systems.
安全性プロファイル
A human poison by ingestion and intravenous routes. Poison experimentally by ingestion, intravenous, intraperitoneal, subcutaneous, rectal, and parenteral routes. When heated to decomposition it emits toxic fumes of NOx.
純化方法
pKEst Crystallise metrazol from diethyl ether and dry it under vacuum over P2O5, or distil it. [Schmidt Chem Ber 57 704 1924, Beilstein 26 II 213.]
メトラゾール 上流と下流の製品情報
原材料
準備製品