Pentetrazol
- CAS No.
- 54-95-5
- Chemical Name:
- Pentetrazol
- Synonyms
- PTZ;pentylenetetrazol;Tetrazol;PENTYLENETETRAZOLE;Pentetrazole;Metrazol;Pentazol;CARDIAZOLE;TT87;Cortis
- CBNumber:
- CB4248615
- Molecular Formula:
- C6H10N4
- Molecular Weight:
- 138.17
- MDL Number:
- MFCD00005939
- MOL File:
- 54-95-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Pentylenetetrazole | P6500 | 25g | $108 |
| Pentylenetetrazole | P6500 | 50g | $218 |
| 1,5-Pentamethylenetetrazole min. 98.0 % | P0046 | 5G | $45 |
| 1,5-Pentamethylenetetrazole min. 98.0 % | P0046 | 25G | $156 |
| Pentylenetetrazole ≥98% | 18682 | 10g | $49 |
| More product size | |||
| Melting point | 59-61 °C (lit.) |
|---|---|
| Boiling point | 194 °C/12 mmHg (lit.) |
| Density | 1.0617 (rough estimate) |
| refractive index | 1.4910 (estimate) |
| Flash point | 194°C/12mm |
| storage temp. | -20°C |
| solubility | ≥15.38 mg/mL in EtOH; ≥6.3 mg/mL in DMSO; ≥83.2 mg/mL in H2O |
| form | solid |
| pka | 1.25±0.20(Predicted) |
| color | White, crystalline powder |
| Sensitive | Hygroscopic |
| Merck | 14,7141 |
| BRN | 135492 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | 1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2 |
| InChIKey | CWRVKFFCRWGWCS-UHFFFAOYSA-N |
| SMILES | C1CCc2nnnn2CC1 |
| CAS DataBase Reference | 54-95-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | WM5Z385K7T |
| ATC code | R07AB03,R07AB53 |
| NIST Chemistry Reference | Pentylenetetrazol(54-95-5) |
| EPA Substance Registry System | Pentetrazol (54-95-5) |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38-23/24/25 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XF8225000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Toxicity | LD50 in rats (mg/kg): 85±2 s.c., 62 i.p. (Goldenthal) | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Pentetrazol price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P6500 | Pentylenetetrazole | 54-95-5 | 25g | $108 | 2026-04-30 | Buy |
| Sigma-Aldrich | P6500 | Pentylenetetrazole | 54-95-5 | 50g | $218 | 2026-04-30 | Buy |
| TCI Chemical | P0046 | 1,5-Pentamethylenetetrazole min. 98.0 % | 54-95-5 | 5G | $45 | 2026-04-30 | Buy |
| TCI Chemical | P0046 | 1,5-Pentamethylenetetrazole min. 98.0 % | 54-95-5 | 25G | $156 | 2026-04-30 | Buy |
| Cayman Chemical | 18682 | Pentylenetetrazole ≥98% | 54-95-5 | 10g | $49 | 2026-04-30 | Buy |
Pentetrazol Chemical Properties,Uses,Production
Description
Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals. Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures. PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABAA receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABAA receptor.
Chemical Properties
white crystalline powder
Originator
Pentylenetetrazole,Spectrum Chemicals and
Uses
Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.
Uses
Non-specific CNS stimulant; convulsant; narcotic antagonist.
Uses
analeptic, circulation stimulant
Definition
ChEBI: An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other espiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Manufacturing Process
A solution of 9.8 g cyclohexanone and 8.6 g HNO3 in about 250 ml benzene were slowly added dropwise to 20 ml concentrate sulfuric acid in 100 ml benzene by ice cooling and stirring. After ending of a generation of N2 (0.1 moles) to a corresponding quantity of cyclohexane (0.1 moles). Acid layer was diluted with ice, and made neutral with strong alkaline to give a reaction product as oil. Then it was exrtacted with chloroform, all solvents were distilled and the residue was diluted with water. The desired 6,7,8,9tetrahydro-5H-tetrazoloazepine dropped. Yield was 7.5 g after recrystallization from ester or distillation. M.P: 65°C.
brand name
Cardiazol (Knoll).
Therapeutic Function
Analeptic, Central stimulant
General Description
White crystalline powder or granular solid with a slightly pungent odor. Bitter taste. Aqueous solutions neutral to litmus.
Air & Water Reactions
Dust can be explosive when suspended in air at specific concentrations. Water soluble.
Reactivity Profile
Pentetrazol is incompatible with oxidizing agents. . Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. Azo dyes can be explosive when suspended in air at specific concentrations.
Fire Hazard
Flash point data for Pentetrazol are not available. Pentetrazol is probably combustible.
Biological Activity
CNS stimulant that induces kindling in vivo . Causes alterations in excitatory and inhibitory neurotransmitter systems.
Biochem/physiol Actions
Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures.
Safety Profile
A human poison by ingestion and intravenous routes. Poison experimentally by ingestion, intravenous, intraperitoneal, subcutaneous, rectal, and parenteral routes. When heated to decomposition it emits toxic fumes of NOx.
storage
-20°C
Purification Methods
pKEst Crystallise metrazol from diethyl ether and dry it under vacuum over P2O5, or distil it. [Schmidt Chem Ber 57 704 1924, Beilstein 26 II 213.]
References
[1] LSCHER W. Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs[J]. Seizure-European Journal of Epilepsy, 2011, 20 5: Pages 359-368. DOI: 10.1016/j.seizure.2011.01.003
[2] NATASHA T SNIDER. A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist.[J]. Molecular Pharmacology, 2009, 75 4: 965-972. DOI: 10.1124/mol.108.053439
[3] KRISTIAN KAUFMANN. ML297 (VU0456810), the First Potent and Selective Activator of the GIRK Potassium Channel, Displays Antiepileptic Properties in Mice[J]. ACS Chemical Neuroscience, 2013, 4 9: 1278-1286. DOI: 10.1021/cn400062a
[4] YOHAN CHAIX. Chemoconvulsant-induced Seizure Susceptibility: Toward a Common Genetic Basis[J]. Epilepsia, 2007, 48 s5: 48-52. DOI: 10.1111/j.1528-1167.2007.01289.x
[5] WHITE H S. Clinical Significance of Animal Seizure Models and Mechanism of Action Studies of Potential Antiepileptic Drugs[J]. Epilepsia, 2007, 38 s1: S9-S17. DOI: 10.1111/j.1528-1157.1997.tb04523.x
Pentetrazol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2251 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 | info@afinechem.com | China | 15080 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| R&D Scientific Inc. | +1-2266000236 | sales@rdscientific.com | Canada | 1941 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
View Lastest Price from Pentetrazol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-20 | pentetrazol
54-95-5
|
$50.00 | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2025-01-23 | Pentetrazol
54-95-5
|
$1780.00 | 1g | 98 | 5000 Kg | R&D Scientific Inc. | |
 |
2020-01-05 | Pentetrazol
54-95-5
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- pentetrazol
54-95-5
- $50.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Pentetrazol
54-95-5
- $1780.00
- 98
- R&D Scientific Inc.
-
- Pentetrazol
54-95-5
- $1.00
- 95-99%
- Career Henan Chemical Co
