SB269970塩酸塩

SB269970塩酸塩 価格 もっと(11)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TOC1612	SB269970塩酸塩 SB 269970 hydrochloride	261901-57-9	10mg	￥80000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TOC1612	SB269970塩酸塩 SB 269970 hydrochloride	261901-57-9	50mg	￥328000	2024-03-01	購入
Sigma-Aldrich Japan	S7389	SB-269970 塩酸塩 powder, ≥98% (HPLC) SB-269970 hydrochloride powder, ≥98% (HPLC)	261901-57-9	5mg	￥54600	2024-03-01	購入
Sigma-Aldrich Japan	S7389	SB-269970 塩酸塩 powder, ≥98% (HPLC) SB-269970 hydrochloride powder, ≥98% (HPLC)	261901-57-9	25mg	￥154000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01CAY17081	SB-269970 (hydrochloride)	261901-57-9	5mg	￥27200	2024-03-01	購入

SB269970塩酸塩 化学特性,用途語,生産方法

説明

The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-269970 is a potent 5-HT_7A antagonist (pK_i = 8.9) that demonstrates >50-fold binding selectivity over 5-HT_5A and >250-fold selectivity over 5-HT₁, 5-HT₂, 5-HT₄, 5-HT₆, adrenergic α₁, dopamine D₂, and dopamine D₃ receptors. It is also reported to block adrenergic α₂ receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT₇ receptor in the study of schizophrenia-like cognitive deficits.

使用

SB 269970A is a selective 5-HT7 receptor antagonist.

一般的な説明

A selective 5-HT₇ receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT₇ receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT₇ antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT_5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT_7A, 5-HT_5A and 5-HT_1B).

SB269970塩酸塩 上流と下流の製品情報

原材料

準備製品

SB269970塩酸塩 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29977	65
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2374	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4859	55
SPIRO PHARMA		eric_feng1954@126.com	China	9239	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8435	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58

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• 261901-57-9
• SB-269970A
• (R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride
• (r)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride
• SB 269970A, (R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride
• (2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine monohydrochloride
• Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-, hydrochloride (1:1)
• SB269970 hydrochloride, >=98%
• SB269970 HClSB269970 HCl
• SB269970 HCl USP/EP/BP
• SB269970 HCl (SB-269970A)
• SB-269970A|||SB269970 HCl
• SB 269970 hydrochloride, 5-HT7 receptor antagonist
• SB-269970 hydrochloride, 10 mM in DMSO
• SB269970塩酸塩
• (R)-3-((2-(2-(4-メチルピペリジン-1-イル)エチル)ピロリジン-1-イル)スルホニル)フェノール塩酸塩
• SB-269970 塩酸塩
• 3-({2-[2-(4-メチルピペリジン-1-イル)エチル]ピロリジン-1-イル}スルホニル)フェノール
• 3-[[2-[2-(4-メチルピペリジン-1-イル)エチル]ピロリジン-1-イル]スルホニル]フェノール