SB269970 HCl
- CAS No.
- 261901-57-9
- Chemical Name:
- SB269970 HCl
- Synonyms
- SB-269970A;SB269970 HCl USP/EP/BP;SB269970 HClSB269970 HCl;SB-269970A|||SB269970 HCl;SB269970 HCl (SB-269970A);SB269970 hydrochloride, >=98%;SB-269970 hydrochloride, 10 mM in DMSO;SB 269970 hydrochloride, 5-HT7 receptor antagonist;(r)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride;(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride
- CBNumber:
- CB5972915
- Molecular Formula:
- C18H28N2O3SHCl
- Molecular Weight:
- 0
- MDL Number:
- MFCD03788020
- MOL File:
- 261901-57-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| SB-269970 hydrochloride powder, ≥98% (HPLC) | S7389 | 5mg | $363 |
| SB-269970 hydrochloride powder, ≥98% (HPLC) | S7389 | 25mg | $1260 |
| SB-269970 Hydrochloride - CAS 261901-57-9 - Calbiochem | 5.06415 | 10MG | $207 |
| SB-269970 (hydrochloride) ≥98% | 17081 | 5mg | $97 |
| SB-269970 (hydrochloride) ≥98% | 17081 | 10mg | $184 |
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: soluble10mg/mL, clear (warmed to 60 °C) |
| form | powder |
| color | White to off-white |
| optical activity | [α]/D 75 to 90°, c =1.0 in DMSO |
| Water Solubility | H2O: 10mg/mL, clear (warmed to 60 °C) |
| InChI | 1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1 |
| InChIKey | XQCJOYZLWFNDIO-PKLMIRHRSA-N |
| SMILES | Cl.CC1CCN(CC1)CC[C@H]2CCCN2S(=O)(=O)c3cccc(O)c3 |
| FDA UNII | DKP3XMW7KV |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
SB269970 HCl price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S7389 | SB-269970 hydrochloride powder, ≥98% (HPLC) | 261901-57-9 | 5mg | $363 | 2025-07-31 | Buy |
| Sigma-Aldrich | S7389 | SB-269970 hydrochloride powder, ≥98% (HPLC) | 261901-57-9 | 25mg | $1260 | 2025-07-31 | Buy |
| Sigma-Aldrich | 5.06415 | SB-269970 Hydrochloride - CAS 261901-57-9 - Calbiochem | 261901-57-9 | 10MG | $207 | 2025-07-31 | Buy |
| Cayman Chemical | 17081 | SB-269970 (hydrochloride) ≥98% | 261901-57-9 | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 17081 | SB-269970 (hydrochloride) ≥98% | 261901-57-9 | 10mg | $184 | 2024-03-01 | Buy |
SB269970 HCl Chemical Properties,Uses,Production
Description
The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-269970 is a potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors. It is also reported to block adrenergic α2 receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT7 receptor in the study of schizophrenia-like cognitive deficits.
Uses
SB 269970A is a selective 5-HT7 receptor antagonist.
General Description
A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
Biochem/physiol Actions
Primary Target5-HT
storage
+4°C
References
[1] hagan j j, price g w, jeffrey p, et al. characterization of sb-269970-a, a selective 5-ht7 receptor antagonist. british journal of pharmacology, 2000, 130(3): 539-548.
SB269970 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
SB269970 HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 19781 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4871 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 25378 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
