DCPIB
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- CAS番号.
- 82749-70-0
- 化学名:
- DCPIB
- 别名:
- DCPIB;4-[(2-ブチル-6,7-ジクロロ-2-シクロペンチル-1-オキソ-2,3-ジヒドロ-1H-インデン-5-イル)オキシ]ブタン酸;4-[(1-オキソ-2-ブチル-2-シクロペンチル-6,7-ジクロロインダン-5-イル)オキシ]酪酸
- 英語名:
- DCPIB
- 英語别名:
- DCPIB;DCPIB, 10 mM in DMSO;4-(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYLINDAN-1-ON-5-YL)OXYBUTYRIC ACID;4-(2-butyl-6,7-dichlor-2-cyclopentyl-indan-1-on-5-yl) oxybutyric acid;4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-1-oxo-5-indanyl)oxy]butanoic Acid;4-((2-Butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)butanoic acid;4-[(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYL-2,3-DIHYDRO-1-OXO-1H-INDEN-5-YL)OXY]BUTANOIC ACID;Butanoic acid, 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-;Cl-Channels,Chloride Channel,cardiomyocytes,DCPIB,ischemia,COS-7,KcsA,Potassium Channel,CPAE cell,Inhibitor,inhibit,swelling,rMCAO
- CBNumber:
- CB9215009
- 化学式:
- C22H28Cl2O4
- 分子量:
- 427.36
- MOL File:
- 82749-70-0.mol
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DCPIB 物理性質
- 沸点 :
- 593.8±50.0 °C(Predicted)
- 比重(密度) :
- 1.262±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Store at +4°C
- 溶解性:
- insoluble in H2O; ≥49.8 mg/mL in EtOH; ≥50.8 mg/mL in DMSO
- 外見 :
- solid
- 酸解離定数(Pka):
- 4.53±0.10(Predicted)
- 色:
- White
- InChI:
- 1S/C22H28Cl2O4/c1-2-3-10-22(15-7-4-5-8-15)13-14-12-16(28-11-6-9-17(25)26)19(23)20(24)18(14)21(22)27/h12,15H,2-11,13H2,1H3,(H,25,26)
- InChIKey:
- KHKGTPJPBOQECW-UHFFFAOYSA-N
- SMILES:
- CCCCC1(Cc2cc(OCCCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
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W01TOC1540 |
DCPIB |
82749-70-0 |
10mg |
￥57000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC1540 |
DCPIB |
82749-70-0 |
50mg |
￥240000 |
2024-03-01 |
購入 |
DCPIB 化学特性,用途語,生産方法
使用
DCPIB is a potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells.
生物活性
Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β -cells (IC 50 ~ 2 μ M) and I Cl,swell in various cardiovascular tissues (IC 50 = 4.1 μ M in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl - and K + currents (< 10% inhibition at 10 μ M). Inhibits glucose-stimulated insulin secretion in intact β -cells via VSAC inhibition and indirect K ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro .
DCPIB 上流と下流の製品情報
原材料
準備製品
DCPIB 生産企業
Global( 87)Suppliers
82749-70-0(DCPIB)キーワード:
7-クロロ-1-インダノン
6-クロロ-3,4-ジメチルフェノール
6-クロロ-1-インダノン 塩化物
2,3-ジクロロ-4-ヒドロキシベンズアルデヒド
2,2-ジメチル-4'-メトキシブチロフェノン
1-(3-クロロ-4-エトキシフェニル)エタノン
DCPIB
2-ペンチル-1-インダノン
2',3'-ジクロロ-2,2-ジメチルプロピオフェノン
2',3'-ジクロロ-2,2-ジメチルブチロフェノン
2'-クロロ-2,2-ジメチルブチロフェノン
3'-クロロ-2,2-ジメチルブチロフェノン
2'-クロロ-2,2-ジメチルプロピオフェノン
3'-クロロ-2,2-ジメチルプロピオフェノン
- 82749-70-0
- DCPIB
- 4-[(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYL-2,3-DIHYDRO-1-OXO-1H-INDEN-5-YL)OXY]BUTANOIC ACID
- 4-(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYLINDAN-1-ON-5-YL)OXYBUTYRIC ACID
- Butanoic acid, 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-
- Cl-Channels,Chloride Channel,cardiomyocytes,DCPIB,ischemia,COS-7,KcsA,Potassium Channel,CPAE cell,Inhibitor,inhibit,swelling,rMCAO
- 4-(2-butyl-6,7-dichlor-2-cyclopentyl-indan-1-on-5-yl) oxybutyric acid
- 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-1-oxo-5-indanyl)oxy]butanoic Acid
- 4-((2-Butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)butanoic acid
- DCPIB, 10 mM in DMSO
- DCPIB
- 4-[(2-ブチル-6,7-ジクロロ-2-シクロペンチル-1-オキソ-2,3-ジヒドロ-1H-インデン-5-イル)オキシ]ブタン酸
- 4-[(1-オキソ-2-ブチル-2-シクロペンチル-6,7-ジクロロインダン-5-イル)オキシ]酪酸