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1-[(R)-1-(2-ピリジニル)エチル]-7-(3,5-ジメチルイソオキサゾール-4-イル)-8-メトキシ-1H-イミダゾ[4,5-c]キノリン-2(3H)-オン

1-[(R)-1-(2-ピリジニル)エチル]-7-(3,5-ジメチルイソオキサゾール-4-イル)-8-メトキシ-1H-イミダゾ[4,5-c]キノリン-2(3H)-オン 化学構造式
1300031-49-5
CAS番号.
1300031-49-5
化学名:
1-[(R)-1-(2-ピリジニル)エチル]-7-(3,5-ジメチルイソオキサゾール-4-イル)-8-メトキシ-1H-イミダゾ[4,5-c]キノリン-2(3H)-オン
别名:
1-[(R)-1-(2-ピリジニル)エチル]-7-(3,5-ジメチルイソオキサゾール-4-イル)-8-メトキシ-1H-イミダゾ[4,5-c]キノリン-2(3H)-オン;7-(3,5-ジメチル-1,2-オキサゾール-4-イル)-8-メトキシ-1-[(1R)-1-(ピリジン-2-イル)エチル]-1H,2H,3H-イミダゾ[4,5-c]キノリン-2-オン
英語名:
I-BET151 (GSK1210151A)
英語别名:
CS-358;CS-1920;I-BET 151;GSK 1210151A;I-BET151, >=98%;GSK1210151A ISOMER;GSK1210151A (I-BET151);I-BET 151/GSK 1210151A;I-BET151, 10 mM in DMSO;GSK1210151A/1300031-49-5/98%
CBNumber:
CB92554258
化学式:
C23H21N5O3
分子量:
415.44
MOL File:
1300031-49-5.mol
MSDS File:
SDS

1-[(R)-1-(2-ピリジニル)エチル]-7-(3,5-ジメチルイソオキサゾール-4-イル)-8-メトキシ-1H-イミダゾ[4,5-c]キノリン-2(3H)-オン 物理性質

比重(密度) :
1.314
貯蔵温度 :
2-8°C
溶解性:
DMSO：可溶20mg/mL、透明
外見 :
粉
酸解離定数(Pka):
11.14±0.20(Predicted)
色:
白からベージュ
InChI:
InChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
InChIKey:
VUVUVNZRUGEAHB-CYBMUJFWSA-N
SMILES:
N1C2C(=CC(OC)=C(C3=C(C)ON=C3C)C=2)C2N([C@@H](C3=NC=CC=C3)C)C(=O)NC=2C=1
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T
Rフレーズ  25
Sフレーズ  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
ストレージクラス 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
絵表示（GHS） Skull and Crossbones (GHS06)
注意喚起語 危険
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H301 飲み込むと有毒 急性毒性、経口 3 危険 P264, P270, P301+P310, P321, P330,P405, P501
注意書き
P301+P310 飲み込んだ場合：直ちに医師に連絡すること。

1-[(R)-1-(2-ピリジニル)エチル]-7-(3,5-ジメチルイソオキサゾール-4-イル)-8-メトキシ-1H-イミダゾ[4,5-c]キノリン-2(3H)-オン 価格 もっと(6)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCI120050
I-BET 151 		1300031-49-5 5mg ￥31800 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCI120050
I-BET 151 		1300031-49-5 10mg ￥50600 2023-06-01 購入
Sigma-Aldrich Japan SML0666 ≥98% (HPLC)
GSK1210151A ≥98% (HPLC)		 1300031-49-5 5mg ￥27100 2024-03-01 購入
Sigma-Aldrich Japan SML0666 ≥98% (HPLC)
GSK1210151A ≥98% (HPLC)		 1300031-49-5 25mg ￥104000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCI120050
I-BET 151 		1300031-49-5 50mg ￥192800 2023-06-01 購入

1-[(R)-1-(2-ピリジニル)エチル]-7-(3,5-ジメチルイソオキサゾール-4-イル)-8-メトキシ-1H-イミダゾ[4,5-c]キノリン-2(3H)-オン 化学特性,用途語,生産方法

説明

The bromodomain and extra terminal domain (BET) family of proteins including BRD2, BRD3, and BRD4 play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3, and BRD4 with IC50 values of 0.5, 0.25, and 0.79 μM, respectively. Through this action, it blocks the growth of leukemic cell lines driven by mixed lineage leukemia (MLL) fusions at nanomolar concentrations, whereas tyrosine kinase activated cells were much less sensitive. Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G0/G1 cell cycle arrest in MLL-fusion cell lines. I-BET151 is effective in vivo, suppressing MLL leukemia progression in two different mouse models.

化学的特性

Off-White Solid

使用

I-BET 151 is part of a novel series of quinoline isoxazole BET family bromodomain inhibitors, a family of four proteins that selectively bind to aceylated lysine residues in histone. I-BET 151 play ke y roles in many cellular processes, including anti-inflammatory gene expression, mitosis, and viral/host interaction by controlling the conformation of histone acetylation -dependent chromatin complex es. Studies have shown that I-BET 151 increased ApoA1 expression within the nanomolar range in human hepatic cell line HepG2. The upregulation by I-BET 151 suggested potential anti-inflammatory activi ties upon administration.

1-[(R)-1-(2-ピリジニル)エチル]-7-(3,5-ジメチルイソオキサゾール-4-イル)-8-メトキシ-1H-イミダゾ[4,5-c]キノリン-2(3H)-オン 上流と下流の製品情報

原材料

GSK1210151A S isomer 7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-(1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one [3-(3,5-diMethyl-4-isoxazolyl)-4-(Methyloxy)phenyl]aMine 3,5-ジメチルイソオキサゾール-4-ボロン酸 4-(2-methoxy-5-nitrophenyl)-3,5-dimethylisoxazole diethyl 2-((3-(3,5-dimethylisoxazol-4-yl)-4-methoxyphenylamino)methylene)malonate 4-chloro-7-(3,5-dimethylisoxazol-4-yl)-6-methoxyquinoline-3-carboxamide 3-QuinolinecarboxaMide, 7-(3,5-diMethyl-4-isoxazolyl)-6-Methoxy-4-[[(1R)-1-(2-pyridinyl)ethyl]aMino]- 2-ヨード-4-ニトロアニソール メタノール

準備製品

1-[(R)-1-(2-ピリジニル)エチル]-7-(3,5-ジメチルイソオキサゾール-4-イル)-8-メトキシ-1H-イミダゾ[4,5-c]キノリン-2(3H)-オン 生産企業

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1-[(R)-1-(2-ピリジニル)エチル]-7-(3,5-ジメチルイソオキサゾール-4-イル)-8-メトキシ-1H-イミダゾ[4,5-c]キノリン-2(3H)-オン  スペクトルデータ(1HNMR)

I-BET151 (GSK1210151A)(1300031-49-5)1HNMR

1300031-49-5(1-[(R)-1-(2-ピリジニル)エチル]-7-(3,5-ジメチルイソオキサゾール-4-イル)-8-メトキシ-1H-イミダゾ[4,5-c]キノリン-2(3H)-オン)キーワード:

JQ-1 モリブレシブ BORTEZOMIB (VELCADE) 2-[(9S)-7-(4-クロロフェニル)-4,5,13-トリメチル-3-チア-1,8,11,12-テトラアザトリシクロ[8.3.0.02,6]トリデカ-2(6),4,7,10,12-ペンタエン-9-イル]アセトアミド OTX 015 ロミデプシン カルフィルゾミブ
  • 1300031-49-5
  • 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one
  • I-BET 151/GSK 1210151A
  • GSK1210151A (I-BET151)
  • 7-(3,5-diMethylisoxazol-4-yl)-8-Methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-iMidazo[4,5-c]quinolin-2(3H)-one
  • 7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2
  • GSK 1210151A
  • I-BET 151
  • 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one I-BET151(GSK1210151A)
  • 7-(3,5-Dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-(2-pyridinyl)ethyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
  • I-BET151, >=98%
  • 7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinoli
  • GSK1210151A ISOMER
  • 7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-PYRIDIN-2-YLETHYL]-3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE
  • CS-1920
  • IBET151;I-BET-151;I BET 151;IBET-151;IBET 151
  • CS-358
  • GSK-1210151A;IBET151;I-BET-151;I BET 151;IBET-151;IBET 151;GSK 1210151A
  • 2H-Imidazo[4,5-c]quinolin-2-one, 7-(3,5-dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-
  • I-BET151 (GSK1210151A) USP/EP/BP
  • I-BET151, pan-BET family inhibitor
  • I-BET151, 10 mM in DMSO
  • GSK1210151A/1300031-49-5/98%
  • I-BET151 (GSK1210151A) ，S2780
  • (r)-7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-(1-(pyridin-2-yl)ethyl)-1,3-dihydro-2h-imidazo[4,5-c]quinolin-2-one
  • 1-[(R)-1-(2-ピリジニル)エチル]-7-(3,5-ジメチルイソオキサゾール-4-イル)-8-メトキシ-1H-イミダゾ[4,5-c]キノリン-2(3H)-オン
  • 7-(3,5-ジメチル-1,2-オキサゾール-4-イル)-8-メトキシ-1-[(1R)-1-(ピリジン-2-イル)エチル]-1H,2H,3H-イミダゾ[4,5-c]キノリン-2-オン
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