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ChemicalBook >> CAS DataBase List >> DIACYLGLYCEROL KINASE INHIBITOR II

DIACYLGLYCEROL KINASE INHIBITOR II

DIACYLGLYCEROL KINASE INHIBITOR II price.
  • $36 - $3743.44
  • Product name: DIACYLGLYCEROL KINASE INHIBITOR II
  • CAS: 120166-69-0
  • MF: C28H25F2N3OS
  • MW: 489.58
  • EINECS:
  • MDL Number:MFCD00069258
  • Synonyms:DIACYLGLYCEROL KINASE INHIBITOR I (R59 949);DIACYLGLYCEROL KINASE INHIBITOR II;R59949, 3-[2-[4-(bis(4-Fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone;3-[2-[4-Bis(4-fluorophenyl)methylenepiperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1H)-one;3-[2-[4-(bis(4-Fluorophenyl)Methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, R59949;DAG Kinase Inhibitor II;DAG Kinase Inhibitor;3-[2-(4-[BIS(4-FLUOROPHENYL)-METHYLENE)-1-PIPERIDINYL)ETHYL]-2,3-DIHYDRO-2-THIOXO-4[1H]-QUINAZOLINONE
Price37 Properties Safety Information Description
37 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
Package
  • 1mg
  • 2mg
  • 5mg
  • 0.01g
  • 10mg
  • 0.025g
  • 25mg
  • 0.05g
  • 50mg
  • 100MG
  • 0.1g
  • 0.25g
  • 250MG
  • 1G
  • Manufactureraablocks
  • Product numberAA000QDN
  • Product description3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one ≥98%
  • Packaging1mg
  • Price$36
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000QDN
  • Product description3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one ≥98%
  • Packaging5mg
  • Price$128
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000QDN
  • Product description3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one ≥98%
  • Packaging10mg
  • Price$236
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA000QDN
  • Product description3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one ≥98%
  • Packaging25mg
  • Price$420
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY231597
  • Product descriptionR59949 98%
  • Packaging100MG
  • Price$475
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY231597
  • Product descriptionR59949 98%
  • Packaging250MG
  • Price$715
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY231597
  • Product descriptionR59949 98%
  • Packaging1G
  • Price$1495
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY231597
  • Product descriptionR59949 98%
  • Packaging25MG
  • Price$185
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number8726BA
  • Product descriptionDiacylglycerol Kinase Inhibitor II
  • Packaging25mg
  • Price$522
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000211
  • Product descriptionR-59949 95.00%
  • Packaging1MG
  • Price$590.01
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000211
  • Product descriptionR-59949 95.00%
  • Packaging5MG
  • Price$707.67
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth
  • Product numberFB102452
  • Product descriptionDiacylglycerol kinase inhibitor II
  • Packaging0.025g
  • Price$623.91
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberFB102452
  • Product descriptionDiacylglycerol kinase inhibitor II
  • Packaging0.1g
  • Price$1663.75
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberFB102452
  • Product descriptionDiacylglycerol kinase inhibitor II
  • Packaging0.25g
  • Price$3743.44
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberFB102452
  • Product description3-[2-[4-[Bis(4-Fluorophenyl)Methylene]-1-Piperidinyl]Ethyl]-2,3-Dihydro-2-Thioxo-4(1H)-Quinazolinone
  • Packaging25mg
  • Price$800
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth
  • Product numberFB102452
  • Product descriptionDiacylglycerol kinase inhibitor II
  • Packaging0.05g
  • Price$998.25
  • Updated2026-06-04
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA000QDN 3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one ≥98% 1mg $36 2026-05-25 Buy
aablocks AA000QDN 3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one ≥98% 5mg $128 2026-05-25 Buy
aablocks AA000QDN 3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one ≥98% 10mg $236 2026-05-25 Buy
aablocks AA000QDN 3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one ≥98% 25mg $420 2026-05-25 Buy
ACHEMBLOCK Y231597 R59949 98% 100MG $475 2026-05-27 Buy
ACHEMBLOCK Y231597 R59949 98% 250MG $715 2026-05-27 Buy
ACHEMBLOCK Y231597 R59949 98% 1G $1495 2026-05-27 Buy
ACHEMBLOCK Y231597 R59949 98% 25MG $185 2026-05-27 Buy
AK Scientific 8726BA Diacylglycerol Kinase Inhibitor II 25mg $522 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000211 R-59949 95.00% 1MG $590.01 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000211 R-59949 95.00% 5MG $707.67 2021-12-16 Buy
Biosynth FB102452 Diacylglycerol kinase inhibitor II 0.025g $623.91 2026-06-04 Buy
Biosynth FB102452 Diacylglycerol kinase inhibitor II 0.1g $1663.75 2026-06-04 Buy
Biosynth FB102452 Diacylglycerol kinase inhibitor II 0.25g $3743.44 2026-06-04 Buy
Biosynth FB102452 3-[2-[4-[Bis(4-Fluorophenyl)Methylene]-1-Piperidinyl]Ethyl]-2,3-Dihydro-2-Thioxo-4(1H)-Quinazolinone 25mg $800 2021-12-16 Buy
Biosynth FB102452 Diacylglycerol kinase inhibitor II 0.05g $998.25 2026-06-04 Buy
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Properties

Melting point :228-230 °C
Boiling point :637.1±65.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :0.1 M HCl: slightly soluble
form :solid
pka :11.24±0.20(Predicted)
color :pale yellow
biological source :synthetic (organic)
InChI :1S/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)
InChIKey :ZCNBZFRECRPCKU-UHFFFAOYSA-N
SMILES :Fc1ccc(cc1)\C(=C2\CCN(CCN3C(=S)Nc4ccccc4C3=O)CC2)c5ccc(F)cc5

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

DAG Kinase Inhibitor is an inhibitor of DGK (Diacylglycerol kinase; DAG Kinase) and is useful for elucidating the roles of protein kinase C (PKC). DAG Kinase Inhibitor has also been reported to inhibit DGK in several systems such as isolated platelet membranes, whole platelets and ghost erythrocytes. Additional reports have shown to inhibit in a concentration dependent manner. DAG Kinase Inhibitor may also inhibit other pathways such as NADPH and potentially interfere with the lipid-mediated assembly process of oxidase components as reported using a cell-free system. This particular isoform, R59949, has been reported to potentially exhibit selective inhibition of DGK-α.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
R59949
$35.00
R59949 CAS:120166-69-0
Guangzhou Isun Pharmaceutical Co., Ltd Sigma-Aldrich Shanghai EFE Biological Technology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd. Tianjin Kailiqi Biotechnology Co., Ltd. ShangHai Biochempartner Co.,Ltd Shanghai SuperLan Chemcial Technique Centre Shanghai Jizhi Biochemical Technology Co. Ltd. Career Henan Chemica Co