GGTI 2133 (trifluoroacetate salt)
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- $115 - $6198
- Product name: GGTI 2133 (trifluoroacetate salt)
- CAS: 1217480-14-2
- MF: C29H29F3N4O5
- MW: 570.57
- EINECS:
- MDL Number:
- Synonyms:GGTI 2133 (trifluoroacetate salt);N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-L-leucine,2,2,2-trifluoroacetatesalt;GGTI 2133 TFA
9 prices
Selected condition：
Brand
- aablocks
- Biosynth
- Cayman Chemical
- Sigma-Aldrich
Package
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- Manufactureraablocks
- Product numberAA01FL20
- Product descriptionGGTI 2133 (trifluoroacetate salt)
- Packaging1mg
- Price$347
- Updated2026-05-30
- Buy
- ManufacturerBiosynth
- Product numberSYB48014
- Product descriptionGGTI-2133
- Packaging5mg
- Price$1484.95
- Updated2026-06-05
- Buy
- ManufacturerBiosynth
- Product numberSYB48014
- Product descriptionGGTI-2133
- Packaging10mg
- Price$2065.9
- Updated2026-06-05
- Buy
- ManufacturerBiosynth
- Product numberSYB48014
- Product descriptionGGTI-2133
- Packaging25mg
- Price$3873.75
- Updated2026-06-05
- Buy
- ManufacturerBiosynth
- Product numberSYB48014
- Product descriptionGGTI-2133
- Packaging50mg
- Price$6198
- Updated2026-06-05
- Buy
- ManufacturerCayman Chemical
- Product number23418
- Product descriptionGGTI 2133 (trifluoroacetate salt) ≥95%
- Packaging500μg
- Price$115
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number23418
- Product descriptionGGTI 2133 (trifluoroacetate salt) ≥95%
- Packaging1mg
- Price$213
- Updated2026-04-30
- Buy
- ManufacturerSigma-Aldrich
- Product numberG5294
- Product descriptionGGTI-2133 ≥98%(HPLC),solid
- Packaging1mg
- Price$227
- Updated2026-04-30
- Buy
- ManufacturerSigma-Aldrich
- Product numberG5294
- Product descriptionGGTI-2133 ≥98%(HPLC),solid
- Packaging5mg
- Price$857
- Updated2026-04-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01FL20 | GGTI 2133 (trifluoroacetate salt) | 1mg | $347 | 2026-05-30 | Buy |
| Biosynth | SYB48014 | GGTI-2133 | 5mg | $1484.95 | 2026-06-05 | Buy |
| Biosynth | SYB48014 | GGTI-2133 | 10mg | $2065.9 | 2026-06-05 | Buy |
| Biosynth | SYB48014 | GGTI-2133 | 25mg | $3873.75 | 2026-06-05 | Buy |
| Biosynth | SYB48014 | GGTI-2133 | 50mg | $6198 | 2026-06-05 | Buy |
| Cayman Chemical | 23418 | GGTI 2133 (trifluoroacetate salt) ≥95% | 500μg | $115 | 2026-04-30 | Buy |
| Cayman Chemical | 23418 | GGTI 2133 (trifluoroacetate salt) ≥95% | 1mg | $213 | 2026-04-30 | Buy |
| Sigma-Aldrich | G5294 | GGTI-2133 ≥98%(HPLC),solid | 1mg | $227 | 2026-04-30 | Buy |
| Sigma-Aldrich | G5294 | GGTI-2133 ≥98%(HPLC),solid | 5mg | $857 | 2026-04-30 | Buy |
Properties
Melting point :103-118.5 °C
storage temp. :-20°C
solubility :DMSO: 25 mg/ml
form :A crystalline solid
color :white to beige
InChIKey :FXXUNOYBYJFSRB-UQIIZPHYSA-N
SMILES :OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)c1ccc(NCc2c[nH]cn2)cc1-c3cccc4ccccc34)C(O)=O
storage temp. :-20°C
solubility :DMSO: 25 mg/ml
form :A crystalline solid
color :white to beige
InChIKey :FXXUNOYBYJFSRB-UQIIZPHYSA-N
SMILES :OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)c1ccc(NCc2c[nH]cn2)cc1-c3cccc4ccccc34)C(O)=O
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
GGTI 2133 is a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I; IC50 = 38 nM). It is 140-fold selective for GGTase I over farnesyltransferase (IC50 = 5,400 nM). In vitro, it inhibits geranylgeranylation of RAP1A (IC50 = 10 μM) without inhibiting farnesylation of H-Ras (IC50 = >30 μM). It also inhibits cell growth and decreases migration and invasion of oral squamous cell carcinoma (OSSC) cells to 75, 45, and 27% of control values, respectively. GGTI 2133 (5 mg/kg per day, i.p.) prevents ovalbumin-induced eosinophil infiltration into airways in a mouse model of allergic bronchial asthma but does not prevent an increase in chemokines. It also blocks naloxone-induced contraction of ileum isolated from rats with morphine withdrawal syndrome and dose-dependently decreases withdrawal severity in vivo (ED50 = 0.076 mg/kg).Related product price
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GGTI 2133 (trifluoroacetate salt)
$115-6198 -
191102-87-1
$115-4245