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ChemicalBook >> CAS DataBase List >> 2-TrifluoroMethyl-2'-Methoxychalcone

2-TrifluoroMethyl-2'-Methoxychalcone

$57 - $2120
Product name: 2-TrifluoroMethyl-2'-Methoxychalcone
CAS: 1309371-03-6
MF: C17H13F3O2
MW: 306.28
EINECS:
MDL Number:
Synonyms:2-Propen-1-one, 1-(2-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-, (2E)-;(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one;2-Trifluoromethyl-2'-methoxychalcone;Nrf2 Activator;2-Trifluoromethyl-2′-methoxychalcone, CAS 1309371-03-6;2-Trifluoromethyl-2'-methoxychalcone(solution in acetate);2-Trifluoromethyl-2'-methoxychalcone

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aablocks
AK Scientific
ApexBio Technology
Arctom
Cayman Chemical
ChemScene
Medical Isotopes, Inc.
TRC

Package

5mg
10mg
50mg
100mg
250mg
500mg
1g
5mg(solution)
10mg(solution)
50mg(solution)
100mg(solution)

Manufactureraablocks
Product numberAA009BND
Product description(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one 97%
Packaging250mg
Price$509
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA009BND
Product description(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one 97%
Packaging500mg
Price$727
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA009BND
Product description(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one 97%
Packaging1g
Price$1018
Updated2026-05-28
Buy

ManufacturerAK Scientific
Product number5704DK
Product description2-Trifluoromethyl-2'-methoxychalcone
Packaging50mg
Price$586
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberC3283
Product description2-Trifluoromethyl-2'-methoxychalcone
Packaging50mg(solution)
Price$665
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberC3283
Product description2-Trifluoromethyl-2'-methoxychalcone
Packaging10mg(solution)
Price$158
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberC3283
Product description2-Trifluoromethyl-2'-methoxychalcone
Packaging50mg(solution)
Price$499
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberC3283
Product description2-Trifluoromethyl-2'-methoxychalcone
Packaging5mg(solution)
Price$62
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberC3283
Product description2-Trifluoromethyl-2'-methoxychalcone
Packaging5mg(solution)
Price$83
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberC3283
Product description2-Trifluoromethyl-2'-methoxychalcone
Packaging10mg(solution)
Price$119
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberC3283
Product description2-Trifluoromethyl-2'-methoxychalcone
Packaging100mg(solution)
Price$1165
Updated2026-05-06
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ManufacturerApexBio Technology
Product numberC3283
Product description2-Trifluoromethyl-2'-methoxychalcone
Packaging100mg(solution)
Price$874
Updated2021-12-16
Buy

ManufacturerArctom
Product numberHY-124345
Product description2-Trifluoromethyl-2'-methoxychalcone
Packaging5mg
Price$126
Updated2026-05-26
Buy

ManufacturerCayman Chemical
Product number11881
Product description2-Trifluoromethyl-2'-methoxychalcone ≥98%
Packaging10mg
Price$107
Updated2024-03-01
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ManufacturerCayman Chemical
Product number11881
Product description2-Trifluoromethyl-2''-methoxychalcone ≥98%
Packaging10mg
Price$118
Updated2026-04-30
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ManufacturerCayman Chemical
Product number11881
Product description2-Trifluoromethyl-2''-methoxychalcone ≥98%
Packaging5mg
Price$63
Updated2026-04-30
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA009BND	(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one 97%	250mg	$509	2026-05-28	Buy
aablocks	AA009BND	(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one 97%	500mg	$727	2026-05-28	Buy
aablocks	AA009BND	(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one 97%	1g	$1018	2026-05-28	Buy
AK Scientific	5704DK	2-Trifluoromethyl-2'-methoxychalcone	50mg	$586	2021-12-16	Buy
ApexBio Technology	C3283	2-Trifluoromethyl-2'-methoxychalcone	50mg(solution)	$665	2026-05-06	Buy
ApexBio Technology	C3283	2-Trifluoromethyl-2'-methoxychalcone	10mg(solution)	$158	2026-05-06	Buy
ApexBio Technology	C3283	2-Trifluoromethyl-2'-methoxychalcone	50mg(solution)	$499	2021-12-16	Buy
ApexBio Technology	C3283	2-Trifluoromethyl-2'-methoxychalcone	5mg(solution)	$62	2021-12-16	Buy
ApexBio Technology	C3283	2-Trifluoromethyl-2'-methoxychalcone	5mg(solution)	$83	2026-05-06	Buy
ApexBio Technology	C3283	2-Trifluoromethyl-2'-methoxychalcone	10mg(solution)	$119	2021-12-16	Buy
ApexBio Technology	C3283	2-Trifluoromethyl-2'-methoxychalcone	100mg(solution)	$1165	2026-05-06	Buy
ApexBio Technology	C3283	2-Trifluoromethyl-2'-methoxychalcone	100mg(solution)	$874	2021-12-16	Buy
Arctom	HY-124345	2-Trifluoromethyl-2'-methoxychalcone	5mg	$126	2026-05-26	Buy
Cayman Chemical	11881	2-Trifluoromethyl-2'-methoxychalcone ≥98%	10mg	$107	2024-03-01	Buy
Cayman Chemical	11881	2-Trifluoromethyl-2''-methoxychalcone ≥98%	10mg	$118	2026-04-30	Buy
Cayman Chemical	11881	2-Trifluoromethyl-2''-methoxychalcone ≥98%	5mg	$63	2026-04-30	Buy

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Properties

Boiling point :395.6±42.0 °C(Predicted)
Density :1.238±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤11mg/ml in ethanol;5mg/ml in DMSO;14mg/ml in dimethyl formamide
form :solution in acetate.
color :yellow
SMILES :O=C(/C=C/C1=C(C=CC=C1)C(F)(F)F)C2=C(OC)C=CC=C2

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H225	Highly Flammable liquid and vapour	Flammable liquids	Category 2	Danger	P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H336	May cause drowsiness or dizziness	Specific target organ toxicity,single exposure; Narcotic effects	Category 3	Warning	P261, P271, P304+P340, P312,P403+P233, P405, P501

Precautionary statements:

P210	Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P370+P378	In case of fire: Use … for extinction.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P403+P235	Store in a well-ventilated place. Keep cool.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

Nrf2 activation is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. 2-Trifluoromethyl-2'-methoxychalcone is a potent activator of Nrf2, both in vitro and in mice. Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2'-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1. Furthermore, treatment of mice mice with 50 mg/kg 2-trifluoromethyl-2’-methoxychalcone leads to a 4.5- and 4.6-fold increase in the expression of GCLM and NQO1, respectively, in the small intestine compared to controls.

Suppliers and manufacturers

BOC Sciences J & K SCIENTIFIC LTD. BOC Sciences Shanghai EFE Biological Technology Co., Ltd. Shenzhen Polymeri Biochemical Technology Co., Ltd. Zhuhai Aobokai Biomedical Technology Co., Ltd. ChemeGen(Shanghai) Biotechnology Co.,Ltd. MedBioPharmaceutical Technology Inc Energy Chemical cjbscvictory

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