2-[(2-chlorophenyl)methylideneamino]guanidine
![2-[(2-chlorophenyl)methylideneamino]guanidine
price.](/CAS/20180702/GIF/13098-73-2.gif)
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- $32 - $1900
- Product name: 2-[(2-chlorophenyl)methylideneamino]guanidine
- CAS: 13098-73-2
- MF: C8H9ClN4
- MW: 196.64
- EINECS:
- MDL Number:
- Synonyms:2-[(2-chlorophenyl)methylideneamino]guanidine;NSC 65390;NSC 65390;NSC65390;NSC-65390;SEPHIN 1;SEPHIN1;NSC65390;NSC-65390;IFB-088;Hydrazinecarboximidamide, 2-[(2-chlorophenyl)methylene]-;Inhibitor,protein misfolding diseases,(E/Z)-Icerguastat,Sephin1,Phosphatase,PPP1R15A,PPP1R15B,inhibit,(E/Z)-Sephin1,Sephin-1
31 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- TRC
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 500μg
- 1mg
- 10mM*1mLinDMSO(Solution)
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 10mM(in 1mL DMSO)
- 1g
- 0.5g
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA000V57
- Product descriptionSephin1
- Packaging10mg
- Price$48
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000V57
- Product descriptionSephin1
- Packaging25mg
- Price$68
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000V57
- Product descriptionSephin1
- Packaging50mg
- Price$92
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000V57
- Product descriptionSephin1
- Packaging100mg
- Price$128
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD268748
- Product descriptionSephin 1 98%
- Packaging100MG
- Price$160
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD268748
- Product descriptionSephin 1 98%
- Packaging50MG
- Price$105
- Updated2026-05-27
- Buy
- ManufacturerApexBio Technology
- Product numberA8708
- Product descriptionSephin1
- Packaging10mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8708
- Product descriptionSephin1
- Packaging10mM(in1mLDMSO)
- Price$60
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8708
- Product descriptionSephin1
- Packaging50mg
- Price$130
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8708
- Product descriptionSephin1
- Packaging10mM(in 1mL DMSO)
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-18956
- Product description(E/Z)-Icerguastat 99.44%
- Packaging50mg
- Price$154
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18956
- Product description(E/Z)-Icerguastat 99.44%
- Packaging100mg
- Price$231
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18956
- Product description(E/Z)-Icerguastat 99.44%
- Packaging10mg
- Price$62
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18956
- Product description(E/Z)-Icerguastat 99.44%
- Packaging5mg
- Price$42
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18956
- Product description(E/Z)-Icerguastat 99.44%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$47
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18956
- Product description(E/Z)-Icerguastat 99.44%
- Packaging10mM*1mLinDMSO(Solution)
- Price$47
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000V57 | Sephin1 | 10mg | $48 | 2026-05-25 | Buy |
| aablocks | AA000V57 | Sephin1 | 25mg | $68 | 2026-05-25 | Buy |
| aablocks | AA000V57 | Sephin1 | 50mg | $92 | 2026-05-25 | Buy |
| aablocks | AA000V57 | Sephin1 | 100mg | $128 | 2026-05-25 | Buy |
| ACHEMBLOCK | AD268748 | Sephin 1 98% | 100MG | $160 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD268748 | Sephin 1 98% | 50MG | $105 | 2026-05-27 | Buy |
| ApexBio Technology | A8708 | Sephin1 | 10mg | $50 | 2026-05-06 | Buy |
| ApexBio Technology | A8708 | Sephin1 | 10mM(in1mLDMSO) | $60 | 2026-05-06 | Buy |
| ApexBio Technology | A8708 | Sephin1 | 50mg | $130 | 2026-05-06 | Buy |
| ApexBio Technology | A8708 | Sephin1 | 10mM(in 1mL DMSO) | $55 | 2021-12-16 | Buy |
| Arctom | HY-18956 | (E/Z)-Icerguastat 99.44% | 50mg | $154 | 2026-05-26 | Buy |
| Arctom | HY-18956 | (E/Z)-Icerguastat 99.44% | 100mg | $231 | 2026-05-26 | Buy |
| Arctom | HY-18956 | (E/Z)-Icerguastat 99.44% | 10mg | $62 | 2026-05-26 | Buy |
| Arctom | HY-18956 | (E/Z)-Icerguastat 99.44% | 5mg | $42 | 2026-05-26 | Buy |
| Arctom | HY-18956 | (E/Z)-Icerguastat 99.44% | 10mM*1mLinDMSO(Solid+Solvent) | $47 | 2026-05-26 | Buy |
| Arctom | HY-18956 | (E/Z)-Icerguastat 99.44% | 10mM*1mLinDMSO(Solution) | $47 | 2026-05-26 | Buy |
Properties
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥7.75 mg/mL in DMSO
form :solid
color :White to off-white
solubility :insoluble in H2O; insoluble in EtOH; ≥7.75 mg/mL in DMSO
form :solid
color :White to off-white
Safety Information
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Description
Protein phosphatase 1C (PP1c) dephosphorylates the eukaryotic translation initiation factor 2α subunit (eIF2α) to turn off the unfolded protein response in the endoplasmic reticulum (ER). PP1c removes phosphates on eIF2α under the direction of one of two accessory subunits termed protein phosphatase 1 regulatory subunit 15A and 15B (PPP1R15A and PPP1R15B). Whereas PPP1R15B is constitutively expressed, PPP1R15A is induced by protein-misfolding stress. Sephin1 is a selective inhibitor of the stress-induced PPP1R15A that does not affect the constitutive PPP1R15B. At 50 μM, it has been shown to prolong eIF2α phosphorylation after ER stress, delaying translation which protects cells from misfolded protein-induced cytotoxicity. At 1-5 mg/kg, sephin1 has been shown to prevent defects resulting from protein misfolding in a mutant SOD1 mouse model of fast-progressing amyotrophic lateral sclerosis as well as a mouse model of Charcot-Marie-Tooth neuropathy.Related product price
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