2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurinetrihydrochloride
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- $32 - $3374.8
- Product name: 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurinetrihydrochloride
- CAS: 294646-77-8
- MF: C24H29N7O
- MW: 431.53
- EINECS:
- MDL Number:MFCD18785641
- Synonyms:(R)-CR8;2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurinetrihydrochloride;1-Butanol,2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]Methyl]aMino]-9H-purin-2-yl]aMino]-,(2R)-;(S)-CR8;(2R)-2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol;CR8, (R)-Isomer ;(2R)-2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-butanol-1;(R)-2-(1-Hydroxybut-2-ylamino)-6-[4-(2-pyridyl)phenylmethylamino]-9-iso-propylpurine
48 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- Arctom
- AvaChem
- Axon Medchem
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 10mM*1mLinDMSO(Solution)
- 250MG
- 0.5g
- 1G
- Manufactureraablocks
- Product numberAA002YDI
- Product descriptionCR8, (R)-Isomer 99%
- Packaging1mg
- Price$32
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002YDI
- Product descriptionCR8, (R)-Isomer 99%
- Packaging10mg
- Price$79
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002YDI
- Product descriptionCR8, (R)-Isomer 99%
- Packaging25mg
- Price$193
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002YDI
- Product descriptionCR8, (R)-Isomer 99%
- Packaging50mg
- Price$309
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002YDI
- Product descriptionCR8, (R)-Isomer 99%
- Packaging100mg
- Price$469
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203143
- Product description(R)-CR8 98.00%
- Packaging100MG
- Price$470
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203143
- Product description(R)-CR8 98.00%
- Packaging250MG
- Price$800
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX203143
- Product description(R)-CR8 98.00%
- Packaging1G
- Price$2400
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-MR-C0003-M050
- Product description(R)-CR8 ≥98%(NMR)
- Packaging50mg
- Price$550
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-MR-C0003-M010
- Product description(R)-CR8 ≥98%(NMR)
- Packaging10mg
- Price$260
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0039-M001
- Product description(R)-CR8 ≥98%(NMR)
- Packaging1mg
- Price$60
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0039-M005
- Product description(R)-CR8 ≥98%(NMR)
- Packaging5mg
- Price$180
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number3878BB
- Product description(2R)-2-({9-(1-Methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol
- Packaging10mg
- Price$403
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBRS0000851
- Product description(R)-CR8 95.00%
- Packaging5MG
- Price$815.02
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBRS0000851
- Product description(R)-CR8 95.00%
- Packaging25MG
- Price$1474.7
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-18340
- Product description(R)-CR8 99.52%
- Packaging25mg
- Price$357
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA002YDI | CR8, (R)-Isomer 99% | 1mg | $32 | 2026-05-28 | Buy |
| aablocks | AA002YDI | CR8, (R)-Isomer 99% | 10mg | $79 | 2026-05-28 | Buy |
| aablocks | AA002YDI | CR8, (R)-Isomer 99% | 25mg | $193 | 2026-05-28 | Buy |
| aablocks | AA002YDI | CR8, (R)-Isomer 99% | 50mg | $309 | 2026-05-28 | Buy |
| aablocks | AA002YDI | CR8, (R)-Isomer 99% | 100mg | $469 | 2026-05-28 | Buy |
| ACHEMBLOCK | X203143 | (R)-CR8 98.00% | 100MG | $470 | 2026-05-27 | Buy |
| ACHEMBLOCK | X203143 | (R)-CR8 98.00% | 250MG | $800 | 2026-05-27 | Buy |
| ACHEMBLOCK | X203143 | (R)-CR8 98.00% | 1G | $2400 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-MR-C0003-M050 | (R)-CR8 ≥98%(NMR) | 50mg | $550 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-MR-C0003-M010 | (R)-CR8 ≥98%(NMR) | 10mg | $260 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0039-M001 | (R)-CR8 ≥98%(NMR) | 1mg | $60 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0039-M005 | (R)-CR8 ≥98%(NMR) | 5mg | $180 | 2026-05-06 | Buy |
| AK Scientific | 3878BB | (2R)-2-({9-(1-Methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol | 10mg | $403 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000851 | (R)-CR8 95.00% | 5MG | $815.02 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000851 | (R)-CR8 95.00% | 25MG | $1474.7 | 2021-12-16 | Buy |
| Arctom | HY-18340 | (R)-CR8 99.52% | 25mg | $357 | 2026-05-26 | Buy |
Properties
Melting point :98-100℃
Boiling point :671.4±65.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
pka :14.56±0.10(Predicted)
color :off-white
Stability :Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :HOCBJBNQIQQQGT-LJQANCHMSA-N
SMILES :CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c3ccccn3)c4ncn(C(C)C)c4n1
Boiling point :671.4±65.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
pka :14.56±0.10(Predicted)
color :off-white
Stability :Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :HOCBJBNQIQQQGT-LJQANCHMSA-N
SMILES :CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c3ccccn3)c4ncn(C(C)C)c4n1
Safety Information
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Description
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-CR8 is a second-generation analog of (R)-roscovitine that inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T with IC50 values of 0.09, 0.072, 0.041, 0.11, and 0.18 μM, respectively. (R)-CR8 has 2- to 4-fold improved potency for the inhibition of CDKs over (R)-roscovitine and can inhibit the proliferation of various cancer cell lines with ~40-fold more potency than (R)-roscovitine (IC50s ~ 0.39 versus 27.8 μM, respectively). (R)-CR8 also inhibits casein kinase 1 (CK1δ/ε) with an IC50 value of 0.40 μM and inhibits GSK3α/β with an IC50 value of 12 μM.More related product prices
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