3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
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- $12 - $1200
- Product name: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
- CAS: 338967-87-6
- MF: C15H10Cl2N2O2S
- MW: 353.22
- EINECS:
- MDL Number:MFCD00974506
- Synonyms:3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone;Mdivi1/Mdivi-1;Mitochondrial division inhibitor 1;3-(2,4-DICHLORO-5-METHOXYPHENYL)-2-THIOXO-2,3-DIHYDROQUINAZOLIN-4(1H)-ONE EXACT;Mitochondrial Division Inhibitor, mdivi-1 ;4(1H)-Quinazolinone, 3-(2,4-dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-;3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Mdivi-1;Mitochondrial division inhibitor 1 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
94 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biosynth
- Cayman Chemical
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10mM(1mLinDMSO)
- 10mM*1mLinDMSO
- 10mM*1mLinDMSO(Solution)
- 20mg
- 50
- 1mg
- 5mg
- 10mg
- 10
- 25mg
- 50.00mg
- 50mg
- 100.00mg
- 100mg
- 250.00mg
- 1G
- 10mM*1mLinDMSO(Solid+Solvent)
- 200mg
- 500mg
- 250mg
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA00C0UI
- Product descriptionMdivi-1 98%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C0UI
- Product descriptionMdivi-1 98%
- Packaging5mg
- Price$22
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C0UI
- Product descriptionMdivi-1 98%
- Packaging10mg
- Price$30
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C0UI
- Product descriptionMdivi-1 98%
- Packaging50mg
- Price$77
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C0UI
- Product descriptionMdivi-1 98%
- Packaging100mg
- Price$130
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C0UI
- Product descriptionMdivi-1 98%
- Packaging250mg
- Price$198
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33929
- Product descriptionMdivi-1 98%
- Packaging100MG
- Price$130
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33929
- Product descriptionMdivi-1 98%
- Packaging250MG
- Price$315
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33929
- Product descriptionMdivi-1 98%
- Packaging1G
- Price$785
- Updated2026-05-27
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000199
- Product descriptionMDIVI-1 95.00%
- Packaging10MG
- Price$624.57
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000199
- Product descriptionMDIVI-1 95.00%
- Packaging5MG
- Price$160.6
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4472
- Product descriptionMdivi1
- Packaging50mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4472
- Product descriptionMdivi 1
- Packaging50mg
- Price$200
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4472
- Product descriptionMdivi 1
- Packaging10mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4472
- Product descriptionMdivi 1
- Packaging10mM(in1mLDMSO)
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-15886
- Product descriptionMdivi-1 99.96%
- Packaging5mg
- Price$57
- Updated2026-05-25
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00C0UI | Mdivi-1 98% | 1mg | $12 | 2026-05-28 | Buy |
| aablocks | AA00C0UI | Mdivi-1 98% | 5mg | $22 | 2026-05-28 | Buy |
| aablocks | AA00C0UI | Mdivi-1 98% | 10mg | $30 | 2026-05-28 | Buy |
| aablocks | AA00C0UI | Mdivi-1 98% | 50mg | $77 | 2026-05-28 | Buy |
| aablocks | AA00C0UI | Mdivi-1 98% | 100mg | $130 | 2026-05-28 | Buy |
| aablocks | AA00C0UI | Mdivi-1 98% | 250mg | $198 | 2026-05-28 | Buy |
| ACHEMBLOCK | O33929 | Mdivi-1 98% | 100MG | $130 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33929 | Mdivi-1 98% | 250MG | $315 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33929 | Mdivi-1 98% | 1G | $785 | 2026-05-27 | Buy |
| American Custom Chemicals Corporation | INB0000199 | MDIVI-1 95.00% | 10MG | $624.57 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000199 | MDIVI-1 95.00% | 5MG | $160.6 | 2021-12-16 | Buy |
| ApexBio Technology | A4472 | Mdivi1 | 50mg | $200 | 2021-12-16 | Buy |
| ApexBio Technology | A4472 | Mdivi 1 | 50mg | $200 | 2026-05-06 | Buy |
| ApexBio Technology | A4472 | Mdivi 1 | 10mg | $50 | 2026-05-06 | Buy |
| ApexBio Technology | A4472 | Mdivi 1 | 10mM(in1mLDMSO) | $55 | 2026-05-06 | Buy |
| Arctom | HY-15886 | Mdivi-1 99.96% | 5mg | $57 | 2026-05-25 | Buy |
Properties
Melting point :289 °C
Boiling point :522.5±60.0 °C(Predicted)
Density :1.57±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >20mg/mL
form :White solid
pka :9.91±0.20(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
InChIKey :NZJKEVWTYMOYOR-UHFFFAOYSA-N
SMILES :COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl
Boiling point :522.5±60.0 °C(Predicted)
Density :1.57±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >20mg/mL
form :White solid
pka :9.91±0.20(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
InChIKey :NZJKEVWTYMOYOR-UHFFFAOYSA-N
SMILES :COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Mitochondrial fusion and division proteins function via self assembly to regulate membrane dynamics during various cellular events. For example, the self assembly of dynamin-1, a mitochondrial protein that facilitates endocytosis, with a dynamin related-GTPase (Dnm1 (yeast)/Drp1(mammals)), a mitochondrial protein that functions during mitochondrial division, is thought to regulate apoptosis. Mdivi 1 is a quinazolinone derivative that selectively inhibits mitochondrial division by blocking dynamin GTPase activity in yeast (IC50 = 1-10 μM) and mammalian cells (IC50 = ~50 μM). It has been shown to prevent apoptosis by inhibiting mitochondrial outer membrane permeabilization in vivo and to block Bid-activated Bax/Bak-dependent cytochrome c release from mitochondria in vitro. It has been used to maintain mitochondrial integrity and to prevent cell death in models of pathological conditions including cancer, heart failure, and ischemia and reperfusion injuries.Related product price
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