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ChemicalBook >> CAS DataBase List >> 4'-Hydroxychalcone

4'-Hydroxychalcone

4'-Hydroxychalcone price.
  • $5 - $1137.68
  • Product name: 4'-Hydroxychalcone
  • CAS: 2657-25-2
  • MF: C15H12O2
  • MW: 224.25
  • EINECS:
  • MDL Number:MFCD00016484
  • Synonyms:2-Benzal-4'-hydroxyacetophenone 2-Benzylidene-4'-hydroxyacetophenone;1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one;1-(p-Hydroxyphenyl)-3-phenyl-2-propene-1-one;4'-Hydroxychalcone,97%;4'-Hydroxychalcone 98%;HYDROXYCHALCONE, 4-(RG);4'-Hydroxychalcone98%;HYDROXYCHALCONE, 4'-
Price64 Properties Safety Information Description
64 prices
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  • aablocks
  • Activate Scientific
  • AHH
  • AK Scientific
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  • American Custom Chemicals Corporation
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Package
  • 250MG
  • 10.00g
  • 25.00g
  • 10mM*1mLinDMSO(Solution)
  • 50g
  • 100.00g
  • 250 mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 100mg
  • 1g
  • 5g
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  • 25g
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  • 500g
  • Manufactureraablocks
  • Product numberAA002TNW
  • Product description1-(4-Hydroxyphenyl)-3-Phenylprop-2-en-1-One 97%
  • Packaging100mg
  • Price$9
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002TNW
  • Product description1-(4-Hydroxyphenyl)-3-Phenylprop-2-en-1-One ≥95%(HPLC)
  • Packaging1g
  • Price$10
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002TNW
  • Product description1-(4-Hydroxyphenyl)-3-Phenylprop-2-en-1-One ≥95%(HPLC)
  • Packaging5g
  • Price$14
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002TNW
  • Product description1-(4-Hydroxyphenyl)-3-Phenylprop-2-en-1-One 97%
  • Packaging10g
  • Price$24
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA002TNW
  • Product description1-(4-Hydroxyphenyl)-3-Phenylprop-2-en-1-One 97%
  • Packaging25g
  • Price$41
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA002TNW
  • Product description1-(4-Hydroxyphenyl)-3-Phenylprop-2-en-1-One ≥95%(HPLC)
  • Packaging500g
  • Price$683
  • Updated2026-05-28
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS43512
  • Product description1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97%
  • Packaging25g
  • Price$90
  • Updated2026-06-04
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS43512
  • Product description1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97%
  • Packaging100g
  • Price$237
  • Updated2026-06-04
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  • ManufacturerActivate Scientific
  • Product numberAS43512
  • Product description1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97%
  • Packaging5g
  • Price$26
  • Updated2026-06-04
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  • ManufacturerAHH
  • Product numberMT-14943
  • Product description4'-Hydroxychalcone 97%
  • Packaging500g
  • Price$535
  • Updated2026-05-26
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  • ManufacturerAK Scientific
  • Product numberC135
  • Product description4'-Hydroxychalcone 99%(HPLC)
  • Packaging100g
  • Price$194
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberJ92680
  • Product description4'-Hydroxychalcone 97%
  • Packaging100g
  • Price$145
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberJ92680
  • Product description4'-Hydroxychalcone 97%
  • Packaging25g
  • Price$46
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberC135
  • Product description4'-Hydroxychalcone 99%(HPLC)
  • Packaging5g
  • Price$22
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberC135
  • Product description4'-Hydroxychalcone 99%(HPLC)
  • Packaging25g
  • Price$62
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberC135
  • Product description4'-Hydroxychalcone 99%(HPLC)
  • Packaging1g
  • Price$16
  • Updated2026-06-04
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA002TNW 1-(4-Hydroxyphenyl)-3-Phenylprop-2-en-1-One 97% 100mg $9 2026-05-28 Buy
aablocks AA002TNW 1-(4-Hydroxyphenyl)-3-Phenylprop-2-en-1-One ≥95%(HPLC) 1g $10 2026-05-28 Buy
aablocks AA002TNW 1-(4-Hydroxyphenyl)-3-Phenylprop-2-en-1-One ≥95%(HPLC) 5g $14 2026-05-28 Buy
aablocks AA002TNW 1-(4-Hydroxyphenyl)-3-Phenylprop-2-en-1-One 97% 10g $24 2026-05-28 Buy
aablocks AA002TNW 1-(4-Hydroxyphenyl)-3-Phenylprop-2-en-1-One 97% 25g $41 2026-05-28 Buy
aablocks AA002TNW 1-(4-Hydroxyphenyl)-3-Phenylprop-2-en-1-One ≥95%(HPLC) 500g $683 2026-05-28 Buy
Activate Scientific AS43512 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97% 25g $90 2026-06-04 Buy
Activate Scientific AS43512 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97% 100g $237 2026-06-04 Buy
Activate Scientific AS43512 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one 97% 5g $26 2026-06-04 Buy
AHH MT-14943 4'-Hydroxychalcone 97% 500g $535 2026-05-26 Buy
AK Scientific C135 4'-Hydroxychalcone 99%(HPLC) 100g $194 2026-06-04 Buy
AK Scientific J92680 4'-Hydroxychalcone 97% 100g $145 2026-06-04 Buy
AK Scientific J92680 4'-Hydroxychalcone 97% 25g $46 2026-06-04 Buy
AK Scientific C135 4'-Hydroxychalcone 99%(HPLC) 5g $22 2026-06-04 Buy
AK Scientific C135 4'-Hydroxychalcone 99%(HPLC) 25g $62 2026-06-04 Buy
AK Scientific C135 4'-Hydroxychalcone 99%(HPLC) 1g $16 2026-06-04 Buy
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Properties

Melting point :174-178 °C
Boiling point :419.6±45.0 °C(Predicted)
Density :1.191±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Room Temperature
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
form :powder to crystal
pka :7.72±0.15(Predicted)
color :Light orange to Yellow to Green
BRN :2049150
InChI :InChI=1S/C15H12O2/c16-14-9-7-13(8-10-14)15(17)11-6-12-4-2-1-3-5-12/h1-11,16H
InChIKey :UAHGNXFYLAJDIN-IZZDOVSWSA-N
SMILES :C(C1=CC=C(O)C=C1)(=O)C=CC1=CC=CC=C1
LogP :3.650 (est)
CAS DataBase Reference :2657-25-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.

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Suppliers and manufacturers

Heze Lize Biotechnology Co., Ltd. J & K SCIENTIFIC LTD. Meryer (Shanghai) Chemical Technology Co., Ltd. Alfa Aesar TCI (Shanghai) Development Co., Ltd. Energy Chemical Wuhan Chemwish Technology Co., Ltd Shanghai Sinch Parmaceuticals Tech. Co. Ltd. Adamas Reagent, Ltd. Shandong Xiya Chemical Co., Ltd