ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
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- $36 - $2120
- Product name: ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
- CAS: 4450-98-0
- MF: C14H15NO4
- MW: 261.27
- EINECS:
- MDL Number:MFCD00179167
- Synonyms:1-Ebpc;1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester;Nsc 229530;1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester;1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester;2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester;CP-10668;Aldose Reductase,inhibit,EBPC,Inhibitor
37 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Acints
- Advanced Chemicals Intermediat
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- ChemScene
- CSNpharm
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10.00mg
- 10mg
- 25mg
- 50.00mg
- 50mg
- 100mg
- 250mg
- Manufactureraablocks
- Product numberAA003DX8
- Product descriptionEBPC ≥98%
- Packaging1mg
- Price$36
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003DX8
- Product descriptionEBPC
- Packaging5mg
- Price$80
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003DX8
- Product descriptionEBPC
- Packaging25mg
- Price$183
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003DX8
- Product descriptionEBPC
- Packaging10mg
- Price$111
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003DX8
- Product descriptionEBPC
- Packaging50mg
- Price$253
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003DX8
- Product descriptionEBPC
- Packaging100mg
- Price$351
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY227327
- Product descriptionEBPC 95.00%
- Packaging25MG
- Price$240
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY227327
- Product descriptionEBPC 95.00%
- Packaging100MG
- Price$495
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY227327
- Product descriptionEBPC 95.00%
- Packaging10MG
- Price$135
- Updated2026-05-27
- Buy
- ManufacturerAcints
- Product numberWS-03L-002
- Product description1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 95%+
- Packaging10mg
- Price$67.5
- Updated2026-05-20
- Buy
- ManufacturerAcints
- Product numberWS-03L-002
- Product description1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 95%+
- Packaging50mg
- Price$295.65
- Updated2026-05-20
- Buy
- ManufacturerAdvanced Chemicals Intermediat
- Product numberWS-03L-002
- Product description1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 95%+
- Packaging10mg
- Price$67.5
- Updated2026-05-19
- Buy
- ManufacturerAdvanced Chemicals Intermediat
- Product numberWS-03L-002
- Product description1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 95%+
- Packaging50mg
- Price$295.65
- Updated2026-05-19
- Buy
- ManufacturerAK Scientific
- Product number3779AE
- Product description1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylicacidethylester
- Packaging250mg
- Price$810
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0027395
- Product descriptionEBPC 95.00%
- Packaging10MG
- Price$739.2
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0027395
- Product descriptionEBPC 95.00%
- Packaging1MG
- Price$135.45
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003DX8 | EBPC ≥98% | 1mg | $36 | 2026-05-28 | Buy |
| aablocks | AA003DX8 | EBPC | 5mg | $80 | 2026-05-28 | Buy |
| aablocks | AA003DX8 | EBPC | 25mg | $183 | 2026-05-28 | Buy |
| aablocks | AA003DX8 | EBPC | 10mg | $111 | 2026-05-28 | Buy |
| aablocks | AA003DX8 | EBPC | 50mg | $253 | 2026-05-28 | Buy |
| aablocks | AA003DX8 | EBPC | 100mg | $351 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y227327 | EBPC 95.00% | 25MG | $240 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y227327 | EBPC 95.00% | 100MG | $495 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y227327 | EBPC 95.00% | 10MG | $135 | 2026-05-27 | Buy |
| Acints | WS-03L-002 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 95%+ | 10mg | $67.5 | 2026-05-20 | Buy |
| Acints | WS-03L-002 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 95%+ | 50mg | $295.65 | 2026-05-20 | Buy |
| Advanced Chemicals Intermediat | WS-03L-002 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 95%+ | 10mg | $67.5 | 2026-05-19 | Buy |
| Advanced Chemicals Intermediat | WS-03L-002 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 95%+ | 50mg | $295.65 | 2026-05-19 | Buy |
| AK Scientific | 3779AE | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylicacidethylester | 250mg | $810 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0027395 | EBPC 95.00% | 10MG | $739.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0027395 | EBPC 95.00% | 1MG | $135.45 | 2021-12-16 | Buy |
Properties
Melting point :135-136 °C
Boiling point :479.8±45.0 °C(Predicted)
Density :1.340±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥10mg/mL
form :white powder
pka :4.50±1.00(Predicted)
color :white
InChI :1S/C14H15NO4/c1-2-19-14(18)11-9-15(13(17)12(11)16)8-10-6-4-3-5-7-10/h3-7,16H,2,8-9H2,1H3
InChIKey :IGYRPDIWSYGHMY-UHFFFAOYSA-N
SMILES :CCOC(=O)C1=C(O)C(=O)N(Cc2ccccc2)C1
Boiling point :479.8±45.0 °C(Predicted)
Density :1.340±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥10mg/mL
form :white powder
pka :4.50±1.00(Predicted)
color :white
InChI :1S/C14H15NO4/c1-2-19-14(18)11-9-15(13(17)12(11)16)8-10-6-4-3-5-7-10/h3-7,16H,2,8-9H2,1H3
InChIKey :IGYRPDIWSYGHMY-UHFFFAOYSA-N
SMILES :CCOC(=O)C1=C(O)C(=O)N(Cc2ccccc2)C1
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
The human aldose reductase AKR1B1 is considered the rate limiting enzyme of the polyol pathway responsible for the conversion of glucose into sorbitol. It also acts as a highly efficient PGF2α synthase in response to interleukin-1β. Increased aldose reductase expression has been associated with complications of diabetes and may contribute to reduced efficacy of certain chemotherapeutic drugs. EBPC is a potent, selective inhibitor of aldose reductase with an IC50 value of 47 nM in vitro. Through its regulation of glucose metabolism, EBPC has been used to improve the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. EBPC also inhibits prostaglandin F2α (PGF2α) and PGE2 production in human endometrial cells with an EC50 value of 10 μM.Related product price
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