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ChemicalBook >> CAS DataBase List >> 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione

4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione

4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione price.
  • $9 - $1960
  • Product name: 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
  • CAS: 865854-05-3
  • MF: C19H14N2O2S
  • MW: 334.39
  • EINECS:640-411-8
  • MDL Number:MFCD18633296
  • Synonyms:4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione;Tideglusib(NP-031112);TIDEGLUSIB;NP-12;NP031112;NP 031112;NP031112;NP-031112;1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)-;Destructible
Price57 Properties Safety Information Description
57 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 1mg
  • 5mg
  • 10mg
  • 10mM*1mLinDMSO(Solution)
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 10mM*1mLinDMSO
  • 200mg
  • 0.25g
  • 250mg
  • 250.00mg
  • 0.5g
  • 1g
  • 1.00g
  • 2g
  • 5.00g
  • 5G
  • Manufactureraablocks
  • Product numberAA00362O
  • Product descriptionTideglusib 98%
  • Packaging1mg
  • Price$9
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00362O
  • Product descriptionTideglusib ≥98%
  • Packaging5mg
  • Price$10
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00362O
  • Product descriptionTideglusib 98%
  • Packaging10mg
  • Price$12
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00362O
  • Product descriptionTideglusib ≥98%
  • Packaging25mg
  • Price$15
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00362O
  • Product descriptionTideglusib 98%
  • Packaging50mg
  • Price$22
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00362O
  • Product descriptionTideglusib 98%
  • Packaging100mg
  • Price$33
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00362O
  • Product descriptionTideglusib 98%
  • Packaging250mg
  • Price$53
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00362O
  • Product descriptionTideglusib 98%
  • Packaging1g
  • Price$144
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO32866
  • Product descriptionTideglusib 98%
  • Packaging250MG
  • Price$195
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO32866
  • Product descriptionTideglusib 98%
  • Packaging1G
  • Price$490
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO32866
  • Product descriptionTideglusib 98%
  • Packaging5G
  • Price$1960
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product numberX5395
  • Product description4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
  • Packaging1g
  • Price$1286
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0014171
  • Product descriptionTIDEGLUSIB 95.00%
  • Packaging5MG
  • Price$141.9
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1539
  • Product descriptionTideglusib
  • Packaging50mg
  • Price$120
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1539
  • Product descriptionTideglusib
  • Packaging10mg
  • Price$80
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1539
  • Product descriptionTideglusib
  • Packaging200mg
  • Price$330
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00362O Tideglusib 98% 1mg $9 2026-05-28 Buy
aablocks AA00362O Tideglusib ≥98% 5mg $10 2026-05-28 Buy
aablocks AA00362O Tideglusib 98% 10mg $12 2026-05-28 Buy
aablocks AA00362O Tideglusib ≥98% 25mg $15 2026-05-28 Buy
aablocks AA00362O Tideglusib 98% 50mg $22 2026-05-28 Buy
aablocks AA00362O Tideglusib 98% 100mg $33 2026-05-28 Buy
aablocks AA00362O Tideglusib 98% 250mg $53 2026-05-28 Buy
aablocks AA00362O Tideglusib 98% 1g $144 2026-05-28 Buy
ACHEMBLOCK O32866 Tideglusib 98% 250MG $195 2026-05-27 Buy
ACHEMBLOCK O32866 Tideglusib 98% 1G $490 2026-05-27 Buy
ACHEMBLOCK O32866 Tideglusib 98% 5G $1960 2026-05-27 Buy
AK Scientific X5395 4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione 1g $1286 2021-12-16 Buy
American Custom Chemicals Corporation API0014171 TIDEGLUSIB 95.00% 5MG $141.9 2021-12-16 Buy
ApexBio Technology B1539 Tideglusib 50mg $120 2026-05-06 Buy
ApexBio Technology B1539 Tideglusib 10mg $80 2026-05-06 Buy
ApexBio Technology B1539 Tideglusib 200mg $330 2026-05-06 Buy
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Properties

Melting point :148 - 150oC
Boiling point :511.3±43.0 °C(Predicted)
Density :1.393
storage temp. :2-8°C
solubility :DMSO: >15mg/mL
pka :-1.51±0.20(Predicted)
form :powder
color :white to beige
InChI :InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
InChIKey :PMJIHLSCWIDGMD-UHFFFAOYSA-N
SMILES :S1C(=O)N(CC2=CC=CC=C2)C(=O)N1C1=C2C(C=CC=C2)=CC=C1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity. Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARγ antagonist GW9662 . Interestingly, tideglusib also irreversibly inhibits glycogen synthase kinase-3β (GSK3β) with an IC50 value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 μM without preincubation. Several GSK3 inhibitors, including tideglusib, promote hippocampal neurogenesis both in vitro and in vivo, suggesting suitability in Alzheimer’s therapy.

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Suppliers and manufacturers

Heze Development Zone chuangli Chemical Co., Ltd. Shanghai Boyle Chemical Co., Ltd. Chembest Research Laboratories Limited Nanjing Chemlin Chemical Co., Ltd Jinan Trio PharmaTech Co., Ltd. Spectrum Chemical Manufacturing Corp. Dalian Meilun Biotech Co., Ltd. Shanghai T&W Pharmaceutical Co., Ltd. Haoyuan Chemexpress Co., Ltd. Shanghai Aladdin Bio-Chem Technology Co.,LTD