2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE
![2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE price.](/CAS/GIF/905973-89-9.gif)
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- $19 - $5058.9
- Product name: 2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE
- CAS: 905973-89-9
- MF: C23H18Cl3FN4O3S
- MW: 555.84
- EINECS:
- MDL Number:MFCD09038682
- Synonyms:CS-713;CGK-733; CGK 733;ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem;2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE;CGK733;A-PHENYL-N-[2,2,2-TRICHLORO-1-[[[(4-FLUORO-3-NITROPHENYL)AMINO]THIOXOMETHYL]AMINO]ETHYL]BENZENEACETAMIDE;α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide;alpha-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide
71 prices
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Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 50.00mg
- 100.00mg
- 10mM*1mLinDMSO
- 10mM*1mLinDMSO(Solution)
- 25mg
- 10
- 50
- 250.00mg
- 500mg
- 1000mg
- 5 mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 10mM(in1mLDMSO)
- 5mg
- 10mg
- 50mg
- 10mM(in 1mL DMSO)
- 100mg
- 250mg
- 1G
- 50G
- 500G
- Manufactureraablocks
- Product numberAA00GTZQ
- Product descriptionCGK733 98%
- Packaging50mg
- Price$79
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTZQ
- Product descriptionCGK733 98%
- Packaging100mg
- Price$102
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTZQ
- Product descriptionCGK733 98%
- Packaging250mg
- Price$193
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTZQ
- Product descriptionCGK733 98%
- Packaging10mg
- Price$35
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTZQ
- Product descriptionCGK733 98%
- Packaging5mg
- Price$23
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTZQ
- Product descriptionCGK733 98%
- Packaging1mg
- Price$19
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33891
- Product descriptionCGK 733 98%
- Packaging100MG
- Price$130
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33891
- Product descriptionCGK 733 98%
- Packaging250MG
- Price$245
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33891
- Product descriptionCGK 733 98%
- Packaging1G
- Price$735
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX5280
- Product descriptionCGK733
- Packaging5mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA140835
- Product descriptionCGK733 98+%
- Packaging5mg
- Price$83
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA140835
- Product descriptionCGK733 98+%
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA140835
- Product descriptionCGK733 98+%
- Packaging50mg
- Price$356
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCBL0000356
- Product descriptionCGK733 95.00%
- Packaging50MG
- Price$1138.78
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCBL0000356
- Product descriptionCGK733 95.00%
- Packaging10MG
- Price$685.21
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCBL0000356
- Product descriptionCGK733 95.00%
- Packaging50G
- Price$2437.05
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00GTZQ | CGK733 98% | 50mg | $79 | 2026-05-28 | Buy |
| aablocks | AA00GTZQ | CGK733 98% | 100mg | $102 | 2026-05-28 | Buy |
| aablocks | AA00GTZQ | CGK733 98% | 250mg | $193 | 2026-05-28 | Buy |
| aablocks | AA00GTZQ | CGK733 98% | 10mg | $35 | 2026-05-28 | Buy |
| aablocks | AA00GTZQ | CGK733 98% | 5mg | $23 | 2026-05-28 | Buy |
| aablocks | AA00GTZQ | CGK733 98% | 1mg | $19 | 2026-05-28 | Buy |
| ACHEMBLOCK | O33891 | CGK 733 98% | 100MG | $130 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33891 | CGK 733 98% | 250MG | $245 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33891 | CGK 733 98% | 1G | $735 | 2026-05-27 | Buy |
| AK Scientific | X5280 | CGK733 | 5mg | $49 | 2021-12-16 | Buy |
| Ambeed | A140835 | CGK733 98+% | 5mg | $83 | 2021-12-16 | Buy |
| Ambeed | A140835 | CGK733 98+% | 10mg | $140 | 2021-12-16 | Buy |
| Ambeed | A140835 | CGK733 98+% | 50mg | $356 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CBL0000356 | CGK733 95.00% | 50MG | $1138.78 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CBL0000356 | CGK733 95.00% | 10MG | $685.21 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CBL0000356 | CGK733 95.00% | 50G | $2437.05 | 2021-12-16 | Buy |
Properties
Density :1.502±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :≥27.8 mg/mL in DMSO; insoluble in H2O; ≥5.55 mg/mL in EtOH with gentle warming and ultrasonic
pka :10.15±0.70(Predicted)
form :Pale yellow solid
color :White to off-white
InChI :1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35)
InChIKey :HLCDNLNLQNYZTK-UHFFFAOYSA-N
SMILES :[O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c3ccccc3)C(Cl)(Cl)Cl)ccc1F
storage temp. :Sealed in dry,2-8°C
solubility :≥27.8 mg/mL in DMSO; insoluble in H2O; ≥5.55 mg/mL in EtOH with gentle warming and ultrasonic
pka :10.15±0.70(Predicted)
form :Pale yellow solid
color :White to off-white
InChI :1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35)
InChIKey :HLCDNLNLQNYZTK-UHFFFAOYSA-N
SMILES :[O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c3ccccc3)C(Cl)(Cl)Cl)ccc1F
Safety Information
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Description
Ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) kinases mediate the DNA damage response pathway in cells upon encounter with genotoxic agents. Their signaling can activate cell cycle arrest, DNA repair, induction of premature senescence, and cell death. Inhibiting this pathway is one strategy implemented to increase the therapeutic capacity of certain genotoxic anti-cancer regimens by sensitizing cancer cells to these agents. CGK733, a thiourea-containing compound, was originally identified as a specific inhibitor of ATR and ATM kinases (IC50 = ~ 200 nM). In prematurely senescent breast, lung, and colon cancer cells CGK733 reportedly suppresses ATM-mediated p21 expression required for survival, resulting in cell death. Human cancer cell lines exposed to both caffeine and CGK733 demonstrate a rapid decline in cyclin D1 protein levels and a reduction in retinoblastoma protein levels, which leads to the inhibition of their proliferation.More related product prices
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Suppliers and manufacturers
career henan chemical co
![2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE](https://img.chemicalbook.com/ProductImageEN/2018-12/small/fe498182-1055-4d7c-bbd5-8bbb37f80631.png)
ATK CHEMICAL COMPANY LIMITED
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
Dideu Industries Group Limited
BOC Sciences
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Hangzhou MolCore BioPharmatech Co.,Ltd.
$2.00
2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE CAS:905973-89-9
2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE CAS:905973-89-9
