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ChemicalBook >> CAS DataBase List >> A-1331852

A-1331852

A-1331852 price.
  • $67 - $3772
  • Product name: A-1331852
  • CAS: 1430844-80-6
  • MF: C38H38N6O3S
  • MW: 658.81
  • EINECS:
  • MDL Number:MFCD30532662
  • Synonyms:A-1331852;6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-(adamantylmethyl)-5-methyl-1H-pyrazol-4-yl)picolinic acid;CS-2498;A 1331852;A1331852;6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]pyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 6-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-;3-(1-(Adamantan-1-ylmethyl)-5-methyl-1H-pyrazol-4-yl)-6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinic acid;A-1331852,Inhibitor,inhibit,A1331852,Bcl-2 Family,A 1331852
Price56 Properties Safety Information Description
56 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 1mg
  • 10.00mg
  • 5mg
  • 10mM(1mLinDMSO)
  • 10mM*1mLinDMSO(Solution)
  • 10mg
  • 25.00mg
  • 25mg
  • 50mg
  • 50.00mg
  • 100mg
  • 250mg
  • 1g
  • Manufactureraablocks
  • Product numberAA009ZSC
  • Product description6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid ≥98%
  • Packaging5mg
  • Price$74
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009ZSC
  • Product description6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid 98%
  • Packaging10mg
  • Price$96
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009ZSC
  • Product description6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid 98%
  • Packaging25mg
  • Price$162
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009ZSC
  • Product description6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid 98%
  • Packaging50mg
  • Price$275
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009ZSC
  • Product description6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid 98%
  • Packaging100mg
  • Price$467
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009ZSC
  • Product description6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid 95%
  • Packaging250mg
  • Price$1129
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009ZSC
  • Product description6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid 95%
  • Packaging1g
  • Price$2908
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberM22556
  • Product descriptionA-1331852 98%
  • Packaging1G
  • Price$1950
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberM22556
  • Product descriptionA-1331852 98%
  • Packaging100MG
  • Price$750
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberM22556
  • Product descriptionA-1331852 98%
  • Packaging25MG
  • Price$260
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberM22556
  • Product descriptionA-1331852 98%
  • Packaging5MG
  • Price$95
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number9370DU
  • Product description3-[1-(1-Adamantylmethyl)-5-methylpyrazol-4-yl]-6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]pyridine-2-carboxylicacid
  • Packaging10mg
  • Price$473
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6164
  • Product descriptionA-1331852
  • Packaging25mg
  • Price$337
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6164
  • Product descriptionA-1331852
  • Packaging10mg
  • Price$165
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6164
  • Product descriptionA-1331852
  • Packaging5mg
  • Price$99
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6164
  • Product descriptionA-1331852
  • Packaging100mg
  • Price$858
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009ZSC 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid ≥98% 5mg $74 2026-05-28 Buy
aablocks AA009ZSC 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid 98% 10mg $96 2026-05-28 Buy
aablocks AA009ZSC 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid 98% 25mg $162 2026-05-28 Buy
aablocks AA009ZSC 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid 98% 50mg $275 2026-05-28 Buy
aablocks AA009ZSC 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid 98% 100mg $467 2026-05-28 Buy
aablocks AA009ZSC 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid 95% 250mg $1129 2026-05-28 Buy
aablocks AA009ZSC 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid 95% 1g $2908 2026-05-28 Buy
ACHEMBLOCK M22556 A-1331852 98% 1G $1950 2026-05-27 Buy
ACHEMBLOCK M22556 A-1331852 98% 100MG $750 2026-05-27 Buy
ACHEMBLOCK M22556 A-1331852 98% 25MG $260 2026-05-27 Buy
ACHEMBLOCK M22556 A-1331852 98% 5MG $95 2026-05-27 Buy
AK Scientific 9370DU 3-[1-(1-Adamantylmethyl)-5-methylpyrazol-4-yl]-6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]pyridine-2-carboxylicacid 10mg $473 2021-12-16 Buy
ApexBio Technology B6164 A-1331852 25mg $337 2026-05-06 Buy
ApexBio Technology B6164 A-1331852 10mg $165 2026-05-06 Buy
ApexBio Technology B6164 A-1331852 5mg $99 2026-05-06 Buy
ApexBio Technology B6164 A-1331852 100mg $858 2026-05-06 Buy
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Properties

Melting point :>161oC (dec.)
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Acetonitrile (Slightly, Heated), DMSO (Slightly)
pka :8.88±0.70(Predicted)
form :Solid
color :Pale Yellow to Light Beige
InChIKey :QCQQONWEDCOTBV-UHFFFAOYSA-N
SMILES :C1(C(O)=O)=NC(N2CCC3=C(C2)C(C(NC2=NC4=CC=CC=C4S2)=O)=CC=C3)=CC=C1C1=C(C)N(CC23CC4CC(CC(C4)C2)C3)N=C1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

A-1331852 is an orally bioavailable Bcl-xL inhibitor that selectively binds Bcl-xL over Bcl-2, Mcl-1, and Bcl-W (Kis = <0.01, 6, 142, and 4 nM, respectively). It inhibits growth of Bcl-xL-dependent MOLT-4, but not Bcl-2-dependent RS4;11, acute lymphocytic leukemia cells in vitro (EC50s = 6 and >5,000 nM, respectively). A-1331852 (25 mg/kg twice per day) inhibits tumor growth in a MOLT-4 mouse xenograft model. It also inhibits tumor growth and increases the antitumor activity of docetaxel in MDA-MB-231 LC3 metastatic breast cancer and NCI-H1650 non-small cell lung cancer mouse xenograft models when administered at a dose of 25 mg/kg. A-1331852 also increases venetoclax inhibition of tumor growth in an NCI-H1963.FP5 small cell lung cancer mouse xenograft model.

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Suppliers and manufacturers

Shanghai Luofa Biochemical Technology Co., Ltd. Shanghai YuanQi Biotechnology Co., Ltd. SuZhou GoodChemTech Co., Ltd LGC Science (Shanghai) Ltd. Chembest Research Laboratories Limited MedChemexpress LLC Bide Pharmatech Ltd. Shanghai Lollane Biological Technology Co.,Ltd. Shanghai EFE Biological Technology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd.