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ChemicalBook >> CAS DataBase List >> CAY10594

CAY10594

CAY10594 price.
  • $50 - $1045
  • Product name: CAY10594
  • CAS: 1130067-34-3
  • MF: C26H28N4O2
  • MW: 428.53
  • EINECS:
  • MDL Number:MFCD18382100
  • Synonyms:CAY10594;CAY10594 Exclusive;N-[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-2-naphthalenecarboxamide;2-Naphthalenecarboxamide, N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-;N-(2-(4-Oxo-1-Phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide;CAY10594,Inhibitor,CAY 10594,CAY-10594,Phospholipase,inhibit;CAY10594, 10 mM in DMSO
9 prices
Selected condition:
Brand
  • AK Scientific
  • Cayman Chemical
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 2.5mg
  • 5mg
  • 10mg
  • 25mg
  • ManufacturerAK Scientific
  • Product number2762DC
  • Product descriptionN-[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]naphthalene-2-carboxamide
  • Packaging25mg
  • Price$1045
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13207
  • Product descriptionCAY10594 ≥98%
  • Packaging1mg
  • Price$50
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13207
  • Product descriptionCAY10594 ≥98%
  • Packaging5mg
  • Price$220
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13207
  • Product descriptionCAY10594 ≥98%
  • Packaging10mg
  • Price$389
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13207
  • Product descriptionCAY10594 ≥98%
  • Packaging25mg
  • Price$849
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML2714
  • Product descriptionVU0155072 ≥98% (HPLC)
  • Packaging5MG
  • Price$223
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML2714
  • Product descriptionVU0155072 ≥98%(HPLC)
  • Packaging25MG
  • Price$692
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberC227023
  • Product descriptionCAY10594
  • Packaging1mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberC227023
  • Product descriptionCAY10594
  • Packaging2.5mg
  • Price$130
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2762DC N-[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]naphthalene-2-carboxamide 25mg $1045 2021-12-16 Buy
Cayman Chemical 13207 CAY10594 ≥98% 1mg $50 2024-03-01 Buy
Cayman Chemical 13207 CAY10594 ≥98% 5mg $220 2024-03-01 Buy
Cayman Chemical 13207 CAY10594 ≥98% 10mg $389 2024-03-01 Buy
Cayman Chemical 13207 CAY10594 ≥98% 25mg $849 2024-03-01 Buy
Sigma-Aldrich SML2714 VU0155072 ≥98% (HPLC) 5MG $223 2024-03-01 Buy
Sigma-Aldrich SML2714 VU0155072 ≥98%(HPLC) 25MG $692 2024-03-01 Buy
TRC C227023 CAY10594 1mg $65 2021-12-16 Buy
TRC C227023 CAY10594 2.5mg $130 2021-12-16 Buy

Properties

Boiling point :756.6±60.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:20.0(Max Conc. mg/mL);46.67(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);46.67(Max Conc. mM)
DMSO:PBS(pH7.2) (1:1):0.5(Max Conc. mg/mL);1.17(Max Conc. mM) form :A crystalline solid
pka :14.55±0.46(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are regulated differently and apparently subserve distinct roles. CAY10594 is a potent PLD2 inhibitor, both in vitro (IC50 = 140 nM) and in cells (IC50 = 110 nM). It is also effective as a PLD1 inhibitor at higher concentrations (IC50 = 5.1 μM in vitro, 1.0 μM in cells). CAY10594 strongly inhibits the invasive migration of breast cancer cells in transwell assays, suggesting that PLD might be a useful target in blocking tumor cell invasion.