Eszopiclone
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- $82 - $2000
- Product name: Eszopiclone
- CAS: 138729-47-2
- MF: C17H17ClN6O3
- MW: 388.81
- EINECS:202-303-5
- MDL Number:MFCD03700720
- Synonyms:ESOPICLONE;ESZOPICLONE;(S)-(+)-ZOPICLONE;Dexzopiclone;[(9S)-8-(5-Chloropyridin-2-yl)-7-oxo-2,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-9-yl]4-methylpiperazine-1-carboxylate;ESZOPICLONE CIV;1-Piperazinecarboxylic acid, 4-methyl-, (5S)-6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester (9CI);1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester, (S)-
24 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- DC Chemicals
- Medical Isotopes, Inc.
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 10mM*1mLinDMSO
- 1G
- 2g
- 2.5G
- 5G
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0024379
- Product descriptionESZOPICLONE 95.00%
- Packaging1G
- Price$852.55
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0024379
- Product descriptionESZOPICLONE 95.00%
- Packaging2.5G
- Price$1227.82
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0024379
- Product descriptionESZOPICLONE 95.00%
- Packaging5G
- Price$1548.26
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146149
- Product descriptionEszopiclone >98%
- Packaging1g
- Price$1510
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146149
- Product descriptionEszopiclone >98%
- Packaging250mg
- Price$760
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146149
- Product descriptionEszopiclone >98%
- Packaging100mg
- Price$580
- Updated2026-05-06
- Buy
- ManufacturerBiosynth
- Product numberFE156792
- Product descriptionEszopiclone
- Packaging100mg
- Price$544
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberFE156792
- Product descriptionEszopiclone
- Packaging250mg
- Price$905
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberFE156792
- Product descriptionEszopiclone
- Packaging10mg
- Price$150
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberFE156792
- Product descriptionEszopiclone
- Packaging25mg
- Price$226.75
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberFE156792
- Product descriptionEszopiclone
- Packaging50mg
- Price$363
- Updated2026-06-04
- Buy
- ManufacturerCayman Chemical
- Product number21530
- Product descriptionEszopiclone ≥98%
- Packaging1mg
- Price$82
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number21530
- Product descriptionEszopiclone ≥98%
- Packaging5mg
- Price$326
- Updated2026-04-30
- Buy
- ManufacturerDC Chemicals
- Product numberDC3162
- Product descriptionEszopiclone 98%
- Packaging10mM*1mLinDMSO
- Price$150
- Updated2026-05-24
- Buy
- ManufacturerDC Chemicals
- Product numberDC3162
- Product descriptionEszopiclone >98%
- Packaging100mg
- Price$450
- Updated2026-05-24
- Buy
- ManufacturerDC Chemicals
- Product numberDC3162
- Product descriptionEszopiclone >98%
- Packaging250mg
- Price$600
- Updated2026-05-24
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0024379 | ESZOPICLONE 95.00% | 1G | $852.55 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0024379 | ESZOPICLONE 95.00% | 2.5G | $1227.82 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0024379 | ESZOPICLONE 95.00% | 5G | $1548.26 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146149 | Eszopiclone >98% | 1g | $1510 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb146149 | Eszopiclone >98% | 250mg | $760 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb146149 | Eszopiclone >98% | 100mg | $580 | 2026-05-06 | Buy |
| Biosynth | FE156792 | Eszopiclone | 100mg | $544 | 2026-06-04 | Buy |
| Biosynth | FE156792 | Eszopiclone | 250mg | $905 | 2026-06-04 | Buy |
| Biosynth | FE156792 | Eszopiclone | 10mg | $150 | 2026-06-04 | Buy |
| Biosynth | FE156792 | Eszopiclone | 25mg | $226.75 | 2026-06-04 | Buy |
| Biosynth | FE156792 | Eszopiclone | 50mg | $363 | 2026-06-04 | Buy |
| Cayman Chemical | 21530 | Eszopiclone ≥98% | 1mg | $82 | 2026-04-30 | Buy |
| Cayman Chemical | 21530 | Eszopiclone ≥98% | 5mg | $326 | 2026-04-30 | Buy |
| DC Chemicals | DC3162 | Eszopiclone 98% | 10mM*1mLinDMSO | $150 | 2026-05-24 | Buy |
| DC Chemicals | DC3162 | Eszopiclone >98% | 100mg | $450 | 2026-05-24 | Buy |
| DC Chemicals | DC3162 | Eszopiclone >98% | 250mg | $600 | 2026-05-24 | Buy |
Properties
Melting point :202-204°C
alpha :D20 +135 ±3° (c = 1.0 in acetone)
Boiling point :580.7±50.0 °C(Predicted)
Density :1.54±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form :Solid
pka :6.70±0.10(Predicted)
color :White to Light Beige
Major Application :pharmaceutical
InChI :InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3/t16-/m0/s1
InChIKey :GBBSUAFBMRNDJC-INIZCTEOSA-N
SMILES :N1(C(O[C@H]2C3=NC=CN=C3C(=O)N2C2=NC=C(Cl)C=C2)=O)CCN(C)CC1
CAS DataBase Reference :138729-47-2(CAS DataBase Reference)
alpha :D20 +135 ±3° (c = 1.0 in acetone)
Boiling point :580.7±50.0 °C(Predicted)
Density :1.54±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form :Solid
pka :6.70±0.10(Predicted)
color :White to Light Beige
Major Application :pharmaceutical
InChI :InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3/t16-/m0/s1
InChIKey :GBBSUAFBMRNDJC-INIZCTEOSA-N
SMILES :N1(C(O[C@H]2C3=NC=CN=C3C(=O)N2C2=NC=C(Cl)C=C2)=O)CCN(C)CC1
CAS DataBase Reference :138729-47-2(CAS DataBase Reference)
Safety Information
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Description
Eszopiclone is a non-benzodiazepine hypnotic agent indicated for the treatment of insomnia to induce sleep and for sleep maintenance. It has similar pharmacokinetic and pharmacodynamic parameters as the previously marketed non-benzodiazepine hypnotics zolpidem and zaleplon. However, unlike its predecessors, eszopiclone is not restricted to short-term treatment of insomnia. Clinical studies of up to 6 months of use show that patients do not develop tolerance to its effect. Eszopiclone is the (S)-enantiomer of zopiclone, which has been marketed as the racemic mixture in Europe for almost 20 years. These agents belong to the cyclopyrrolone class of drugs that act as agonists at the type A GABA receptor. Eszopiclone has approximately 50-fold higher binding affinity than its antipode (R)-zopiclone for GABA-A receptor (IC50=21 and 1130 nM, respectively). In addition, the two enantiomers exhibit significant differences in their pharmacokinetic parameters and in vivo efficacy. In healthy volunteers, eszopiclone has 2-fold higher Cmax and 2-fold greater elimination half-life than the (R)-enantiomer.The two most frequent adverse events associated with eszopiclone treatment are unpleasant taste and headache. Other less frequent side effects include somnolence, dry mouth, and nausea.More related product prices
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