GPR39-C3
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- $33 - $1470
- Product name: GPR39-C3
- CAS: 1621175-65-2
- MF: C18H19ClN6O2S
- MW: 418.9
- EINECS:-0
- MDL Number:MFCD30182283
- Synonyms:GPR39-C3;TC-G-1008;N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide;GPR39C3;GPR39 C3;CS-2374;TC-G-1008 (GPR39-C3);Methanesulfonamide, N-[3-chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]-;N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide
21 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- Cayman Chemical
- ChemScene
- DC Chemicals
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10mg
- 25mg
- 50
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number3015EC
- Product descriptionN-[3-Chloro-4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
- Packaging5mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3015EC
- Product descriptionN-[3-Chloro-4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
- Packaging10mg
- Price$246
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA724127
- Product descriptionN-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide 98+%
- Packaging5mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA724127
- Product descriptionN-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide 98+%
- Packaging10mg
- Price$197
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA724127
- Product descriptionN-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide 98+%
- Packaging25mg
- Price$257
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA724127
- Product descriptionN-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide 98+%
- Packaging50mg
- Price$335
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number25445
- Product descriptionGPR39-C3 ≥95%
- Packaging1mg
- Price$33
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25445
- Product descriptionGPR39-C3 ≥95%
- Packaging5mg
- Price$137
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25445
- Product descriptionGPR39-C3 ≥95%
- Packaging10mg
- Price$238
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25445
- Product descriptionGPR39-C3 ≥95%
- Packaging25mg
- Price$515
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-7518
- Product descriptionTC-G-1008 99.03%
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7518
- Product descriptionTC-G-1008 99.03%
- Packaging10mg
- Price$204
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7518
- Product descriptionTC-G-1008 99.03%
- Packaging25mg
- Price$408
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7518
- Product descriptionTC-G-1008 99.03%
- Packaging50mg
- Price$696
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7518
- Product descriptionTC-G-1008 99.03%
- Packaging100mg
- Price$1176
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8206
- Product descriptionGPR39-C3 >98%
- Packaging10mg
- Price$200
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3015EC | N-[3-Chloro-4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide | 5mg | $170 | 2021-12-16 | Buy |
| AK Scientific | 3015EC | N-[3-Chloro-4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide | 10mg | $246 | 2021-12-16 | Buy |
| Ambeed | A724127 | N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide 98+% | 5mg | $118 | 2021-12-16 | Buy |
| Ambeed | A724127 | N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide 98+% | 10mg | $197 | 2021-12-16 | Buy |
| Ambeed | A724127 | N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide 98+% | 25mg | $257 | 2021-12-16 | Buy |
| Ambeed | A724127 | N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide 98+% | 50mg | $335 | 2021-12-16 | Buy |
| Cayman Chemical | 25445 | GPR39-C3 ≥95% | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 25445 | GPR39-C3 ≥95% | 5mg | $137 | 2024-03-01 | Buy |
| Cayman Chemical | 25445 | GPR39-C3 ≥95% | 10mg | $238 | 2024-03-01 | Buy |
| Cayman Chemical | 25445 | GPR39-C3 ≥95% | 25mg | $515 | 2024-03-01 | Buy |
| ChemScene | CS-7518 | TC-G-1008 99.03% | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-7518 | TC-G-1008 99.03% | 10mg | $204 | 2021-12-16 | Buy |
| ChemScene | CS-7518 | TC-G-1008 99.03% | 25mg | $408 | 2021-12-16 | Buy |
| ChemScene | CS-7518 | TC-G-1008 99.03% | 50mg | $696 | 2021-12-16 | Buy |
| ChemScene | CS-7518 | TC-G-1008 99.03% | 100mg | $1176 | 2021-12-16 | Buy |
| DC Chemicals | DC8206 | GPR39-C3 >98% | 10mg | $200 | 2021-12-16 | Buy |
Properties
Boiling point :662.1±65.0 °C(Predicted)
Density :1.462±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO:63.97(Max Conc. mg/mL);152.72(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.38(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);4.77(Max Conc. mM) form :A crystalline solid
pka :7.43±0.10(Predicted)
color :White to off-white
InChI :1S/C18H19ClN6O2S/c1-20-18-23-16(15-5-3-4-8-21-15)10-17(24-18)22-11-12-6-7-13(9-14(12)19)25-28(2,26)27/h3-10,25H,11H2,1-2H3,(H2,20,22,23,24)
InChIKey :DRSZMILOMUPIBJ-UHFFFAOYSA-N
SMILES :CNC1=NC(C2=CC=CC=N2)=CC(NCC3=C(Cl)C=C(NS(C)(=O)=O)C=C3)=N1
Density :1.462±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO:63.97(Max Conc. mg/mL);152.72(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.38(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);4.77(Max Conc. mM) form :A crystalline solid
pka :7.43±0.10(Predicted)
color :White to off-white
InChI :1S/C18H19ClN6O2S/c1-20-18-23-16(15-5-3-4-8-21-15)10-17(24-18)22-11-12-6-7-13(9-14(12)19)25-28(2,26)27/h3-10,25H,11H2,1-2H3,(H2,20,22,23,24)
InChIKey :DRSZMILOMUPIBJ-UHFFFAOYSA-N
SMILES :CNC1=NC(C2=CC=CC=N2)=CC(NCC3=C(Cl)C=C(NS(C)(=O)=O)C=C3)=N1
Safety Information
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Description
GPR39-C3 is a potent agonist of the orphan G protein-coupled receptor GPR39 with EC50 values of 0.8 and 0.4 nM for cAMP production in HEK293 cells expressing human and rat receptors, respectively. It is selective for GPR39 over a panel of kinases (IC50s = >10 μM), ghrelin and neurotensin-1 receptors (IC50s = >30 μM), and a variety of enzymes, transporters, or G protein-coupled receptors. GPR39-C3 increases secretion of glucagon-like peptide 1 (GLP-1; ) in STC-1 mouse enteroendocrine cells (EC50 = 0.06 μM) and is protective against cytokine-induced cell death in INS-1E rat insulinoma cells (EC50 = 0.02 μM). In vivo, GPR39-C3 (30 mg/kg) increases the amount of active GLP-1 in sera by 6-fold in glucose-challenged mice when administered concurrently with a dipeptidyl peptidase 4 (DPP-4) inhibitor.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Career Henan Chemica Co
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Zibo Hangyu Biotechnology Development Co., Ltd
Jilin Chinese Academy of Sciences-yanshen Technology
