L-685 458
|
- $87 - $2600
- Product name: L-685 458
- CAS: 292632-98-5
- MF: C39H52N4O6
- MW: 672.85
- EINECS:
- MDL Number:MFCD03093402
- Synonyms:CS-2367;L-685458 (L-685,458;L-685458;L 685458;L685458;(5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide;N-[(2R,4R,5S)-5-[[(1,1-DiMethylethoxy)carbonyl]aMino]-4-hydroxy-1-oxo-6- phenyl-2-(phenylMethyl)hexyl]-L-leucyl-L-phenylalaninaMide;L-Phenylalaninamide, N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-;Apoptosis,alzheimer’s disease,L 685458,inhibit,L685458,HES1,cancer,Inhibitor,Gamma secretase,γ-secretase,L-685458;L-685,458, gamma-secretase inhibitor
59 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 0.025mg
- 0.05mg
- 0.1mg
- 0.25mg
- 500ug
- 0.5mg
- 1mg
- 2mg
- 10mM(1mLinDMSO)
- 250ug
- 10mM*1mLinDMSO(Solid+Solvent)
- 5mg
- 10mg
- 25mg
- 100mg
- 10mM*1mLinDMSO(Solution)
- 50mg
- Manufactureraablocks
- Product numberAA002XTK
- Product descriptionL-685458 99%
- Packaging1mg
- Price$87
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002XTK
- Product descriptionL-685458 99%
- Packaging5mg
- Price$249
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002XTK
- Product descriptionL-685458 99%
- Packaging10mg
- Price$407
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002XTK
- Product descriptionL-685458 99
- Packaging25mg
- Price$767
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002XTK
- Product descriptionL-685458 99
- Packaging50mg
- Price$1036
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002XTK
- Product descriptionL-685458 99
- Packaging100mg
- Price$1372
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberU102942
- Product descriptionL-685458 98.00%
- Packaging25MG
- Price$1120
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU102942
- Product descriptionL-685458 98.00%
- Packaging100MG
- Price$2025
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU102942
- Product descriptionL-685458 98.00%
- Packaging5MG
- Price$445
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number1682CP
- Product descriptionl-685,458
- Packaging10mg
- Price$232
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA142296
- Product descriptionL-685458 98%
- Packaging5mg
- Price$552
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA142296
- Product descriptionL-685458 98%
- Packaging10mg
- Price$1066
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000845
- Product descriptionL-685,458 95.00%
- Packaging1MG
- Price$774.95
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4404
- Product descriptionL-685,458
- Packaging5mg
- Price$450
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4404
- Product descriptionL-685,458
- Packaging1mg
- Price$140
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-19369
- Product descriptionL-685458 99.48%
- Packaging1mg
- Price$143
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA002XTK | L-685458 99% | 1mg | $87 | 2026-05-28 | Buy |
| aablocks | AA002XTK | L-685458 99% | 5mg | $249 | 2026-05-28 | Buy |
| aablocks | AA002XTK | L-685458 99% | 10mg | $407 | 2026-05-28 | Buy |
| aablocks | AA002XTK | L-685458 99 | 25mg | $767 | 2026-05-28 | Buy |
| aablocks | AA002XTK | L-685458 99 | 50mg | $1036 | 2026-05-28 | Buy |
| aablocks | AA002XTK | L-685458 99 | 100mg | $1372 | 2026-05-28 | Buy |
| ACHEMBLOCK | U102942 | L-685458 98.00% | 25MG | $1120 | 2026-05-27 | Buy |
| ACHEMBLOCK | U102942 | L-685458 98.00% | 100MG | $2025 | 2026-05-27 | Buy |
| ACHEMBLOCK | U102942 | L-685458 98.00% | 5MG | $445 | 2026-05-27 | Buy |
| AK Scientific | 1682CP | l-685,458 | 10mg | $232 | 2021-12-16 | Buy |
| Ambeed | A142296 | L-685458 98% | 5mg | $552 | 2021-12-16 | Buy |
| Ambeed | A142296 | L-685458 98% | 10mg | $1066 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000845 | L-685,458 95.00% | 1MG | $774.95 | 2021-12-16 | Buy |
| ApexBio Technology | A4404 | L-685,458 | 5mg | $450 | 2026-05-06 | Buy |
| ApexBio Technology | A4404 | L-685,458 | 1mg | $140 | 2026-05-06 | Buy |
| Arctom | HY-19369 | L-685458 99.48% | 1mg | $143 | 2026-05-26 | Buy |
Properties
Melting point :212-213 °C
Boiling point :938.5±65.0 °C(Predicted)
Density :1.155±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >10 mg/mL, soluble
form :solid
pka :12.09±0.46(Predicted)
color :white
InChIKey :MURCDOXDAHPNRQ-ZJKZPDEISA-N
SMILES :C(N)(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1
Boiling point :938.5±65.0 °C(Predicted)
Density :1.155±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >10 mg/mL, soluble
form :solid
pka :12.09±0.46(Predicted)
color :white
InChIKey :MURCDOXDAHPNRQ-ZJKZPDEISA-N
SMILES :C(N)(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1
Safety Information
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Description
L-685,458 is a potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. It exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides.More related product prices
tert-butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanyl-OH Z-ILE-PHE-OHRelated product price
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tert-butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanyl-OH
$38-2061 -
Z-ILE-PHE-OH
$128.33-1355
Suppliers and manufacturers
Shanghai fuxiang biotechnology co., ltd
J & K SCIENTIFIC LTD.
3B Pharmachem (Wuhan) International Co.,Ltd.
Chembest Research Laboratories Limited
Shanghai Hanhong Scientific Co.,Ltd.
Chemsky（shanghai）International Co.,Ltd.
Dalian Meilun Biotech Co., Ltd.
Haoyuan Chemexpress Co., Ltd.
MedChemexpress LLC
Nanjing Dulai Biotechnology Co., Ltd.