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ChemicalBook >> CAS DataBase List >> ML414(NGI-1)

ML414(NGI-1)

ML414(NGI-1) price.
  • $49 - $2841
  • Product name: ML414(NGI-1)
  • CAS: 790702-57-7
  • MF: C17H22N4O3S2
  • MW: 394.51
  • EINECS:-0
  • MDL Number:MFCD06358908
  • Synonyms:ML414(NGI-1);ML414;NGI-1;NGI-1; NGI1; NGI 1; ML414; ML 414; ML-414、;NGI-1 (ML414);5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide;ML-414;ML414;NGI 1;NGI1 NEW
Price48 Properties Safety Information Description
48 prices
Selected condition：
Brand
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 25mg
  • 10mM(1mLinDMSO)
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 5
  • 25
  • 250mg
  • 5MG
  • 10mg
  • 50MG
  • 100MG
  • 1g
  • 10mM*1mLinDMSO(Solution)
  • ManufacturerACHEMBLOCK
  • Product numberY229209
  • Product descriptionNGI-1 97.00%
  • Packaging50MG
  • Price$160
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY229209
  • Product descriptionNGI-1 97.00%
  • Packaging100MG
  • Price$290
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number0238CH
  • Product description5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-ylbenzamide
  • Packaging10mg
  • Price$178
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0009737
  • Product descriptionNGI1 95.00%
  • Packaging5MG
  • Price$451.85
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberBA2310
  • Product descriptionNGI-1
  • Packaging50mg
  • Price$252
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberBA2310
  • Product descriptionNGI-1
  • Packaging10mg
  • Price$72
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberBA2310
  • Product descriptionNGI-1
  • Packaging100mg
  • Price$403
  • Updated2026-05-06
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S8750
  • Product descriptionNGI-1 (ML414) 99.9%
  • Packaging1g
  • Price$2841
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S8750
  • Product descriptionNGI-1 (ML414) 99.9%
  • Packaging100mg
  • Price$922
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-117383
  • Product descriptionNGI-1 99.97%
  • Packaging10mM*1mLinDMSO(Solution)
  • Price$74
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-117383
  • Product descriptionNGI-1 99.97%
  • Packaging5mg
  • Price$67
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S8750
  • Product descriptionNGI-1 (ML414) 99.9%
  • Packaging10mg
  • Price$140
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-117383
  • Product descriptionNGI-1 99.97%
  • Packaging10mM*1mLinDMSO(Solid+Solvent)
  • Price$70
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-117383
  • Product descriptionNGI-1 99.97%
  • Packaging10mg
  • Price$105
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-117383
  • Product descriptionNGI-1 99.97%
  • Packaging50mg
  • Price$276
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S8750
  • Product descriptionNGI-1 (ML414) 99.9%
  • Packaging10mM(1mLinDMSO)
  • Price$188
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ACHEMBLOCK Y229209 NGI-1 97.00% 50MG $160 2026-05-27 Buy
ACHEMBLOCK Y229209 NGI-1 97.00% 100MG $290 2026-05-27 Buy
AK Scientific 0238CH 5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-ylbenzamide 10mg $178 2021-12-16 Buy
American Custom Chemicals Corporation INB0009737 NGI1 95.00% 5MG $451.85 2021-12-16 Buy
ApexBio Technology BA2310 NGI-1 50mg $252 2026-05-06 Buy
ApexBio Technology BA2310 NGI-1 10mg $72 2026-05-06 Buy
ApexBio Technology BA2310 NGI-1 100mg $403 2026-05-06 Buy
Arctom SLK-S8750 NGI-1 (ML414) 99.9% 1g $2841 2026-05-26 Buy
Arctom SLK-S8750 NGI-1 (ML414) 99.9% 100mg $922 2026-05-26 Buy
Arctom HY-117383 NGI-1 99.97% 10mM*1mLinDMSO(Solution) $74 2026-05-26 Buy
Arctom HY-117383 NGI-1 99.97% 5mg $67 2026-05-26 Buy
Arctom SLK-S8750 NGI-1 (ML414) 99.9% 10mg $140 2026-05-26 Buy
Arctom HY-117383 NGI-1 99.97% 10mM*1mLinDMSO(Solid+Solvent) $70 2026-05-26 Buy
Arctom HY-117383 NGI-1 99.97% 10mg $105 2026-05-26 Buy
Arctom HY-117383 NGI-1 99.97% 50mg $276 2026-05-26 Buy
Arctom SLK-S8750 NGI-1 (ML414) 99.9% 10mM(1mLinDMSO) $188 2026-05-26 Buy
Next Last

Properties

Density :1.372±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 5 mg/ml)
form :powder
pka :7.48±0.50(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :QPKGRLIYJGBKJL-UHFFFAOYSA-N
SMILES :[S](=O)(=O)(N(C)C)c1cc(c(cc1)N3CCCC3)C(=O)Nc2[s]c(cn2)C

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

NGI-1 (790702-57-7) is a cell-permeable inhibitor of oligosaccharyltransferase (OST) – IC50 = 1.1 μM.1 It blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein and selectively arrests proliferation only in cells dependent on EGFR for survival. NGI-1 caused G1 arrest and senescence in RTK-dependent NSCLC cells (PC9, HCC827, H3255,H1581). NGI-1 displays antiviral behavior against various flaviviruses (Dengue, West Nile, Yellow fever and Zika).2 It also was able to overcome resistance to EGFR tyrosine kinase inhibitors in mutant NSCLC cells3 and enhance radiosensitivity and cytotoxic effects of chemotherapy in glioma cells with high levels of RTK activation4.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
NGI-1
$36.00 /2mg
NGI-1 CAS:790702-57-7
ATK CHEMICAL COMPANY LIMITED
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Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
HANGZHOU LEAP CHEM CO., LTD.
TargetMol Chemicals Inc.
Zibo Hangyu Biotechnology Development Co., Ltd
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