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ChemicalBook >> CAS DataBase List >> Monoethyl fumarate

Monoethyl fumarate

Monoethyl fumarate price.
  • $9 - $2385.67
  • Product name: Monoethyl fumarate
  • CAS: 2459-05-4
  • MF: C6H8O4
  • MW: 144.13
  • EINECS:219-544-7
  • MDL Number:MFCD00002699
  • Synonyms:(2E)-4-Ethoxy-4-oxo-2-butenoic acid;2-Butenedioic acid (E)-, monoethyl ester;Mono-Ethyl fuMarate 95%;Mono-Ethyl FuMarate, 97+%;(2E)-2-Butenedioic Acid Monoethyl Ester;FuMaric Acid Ethyl Ester;Monoethyl FuMerate;Monoethyl trans-2-Butenedioate
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  • aablocks
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  • Manufactureraablocks
  • Product numberAA002OLW
  • Product description(E)-4-Ethoxy-4-oxobut-2-enoic acid ≥97%
  • Packaging25g
  • Price$13
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002OLW
  • Product description(E)-4-Ethoxy-4-oxobut-2-enoic acid 98%
  • Packaging100g
  • Price$19
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002OLW
  • Product description(E)-4-Ethoxy-4-oxobut-2-enoic acid 98%
  • Packaging500g
  • Price$79
  • Updated2026-05-28
  • Buy
  • ManufacturerAK Scientific
  • Product numberF477
  • Product descriptionMonoethyl fumarate >99%(GC)
  • Packaging100g
  • Price$71
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberF477
  • Product descriptionMonoethyl fumarate >99%(GC)
  • Packaging25g
  • Price$27
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95376
  • Product descriptionMonoethyl fumarate 98%
  • Packaging100g
  • Price$52
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95376
  • Product descriptionMonoethyl fumarate 98%
  • Packaging25g
  • Price$19
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95376
  • Product descriptionMonoethyl fumarate 98%
  • Packaging5g
  • Price$13
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberF477
  • Product descriptionMonoethyl Fumarate
  • Packaging25g
  • Price$21
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberF477
  • Product descriptionMonoethyl fumarate >99%(GC)
  • Packaging5g
  • Price$18
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95376
  • Product descriptionMonoethyl fumarate 98%
  • Packaging500g
  • Price$127
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberF477
  • Product descriptionMonoethyl fumarate >99%(GC)
  • Packaging500g
  • Price$174
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95376
  • Product descriptionMonoethyl fumarate 98%
  • Packaging1kg
  • Price$218
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ95376
  • Product descriptionMonoethyl Fumarate
  • Packaging1kg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberF477
  • Product descriptionMonoethyl fumarate >99%(GC)
  • Packaging1kg
  • Price$299
  • Updated2026-06-04
  • Buy
  • ManufacturerAmbeed
  • Product numberA145377
  • Product description(E)-4-Ethoxy-4-oxobut-2-enoicacid 98%
  • Packaging500g
  • Price$87
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA002OLW (E)-4-Ethoxy-4-oxobut-2-enoic acid ≥97% 25g $13 2026-05-28 Buy
aablocks AA002OLW (E)-4-Ethoxy-4-oxobut-2-enoic acid 98% 100g $19 2026-05-28 Buy
aablocks AA002OLW (E)-4-Ethoxy-4-oxobut-2-enoic acid 98% 500g $79 2026-05-28 Buy
AK Scientific F477 Monoethyl fumarate >99%(GC) 100g $71 2026-06-04 Buy
AK Scientific F477 Monoethyl fumarate >99%(GC) 25g $27 2026-06-04 Buy
AK Scientific J95376 Monoethyl fumarate 98% 100g $52 2026-06-04 Buy
AK Scientific J95376 Monoethyl fumarate 98% 25g $19 2026-06-04 Buy
AK Scientific J95376 Monoethyl fumarate 98% 5g $13 2026-06-04 Buy
AK Scientific F477 Monoethyl Fumarate 25g $21 2021-12-16 Buy
AK Scientific F477 Monoethyl fumarate >99%(GC) 5g $18 2026-06-04 Buy
AK Scientific J95376 Monoethyl fumarate 98% 500g $127 2026-06-04 Buy
AK Scientific F477 Monoethyl fumarate >99%(GC) 500g $174 2026-06-04 Buy
AK Scientific J95376 Monoethyl fumarate 98% 1kg $218 2026-06-04 Buy
AK Scientific J95376 Monoethyl Fumarate 1kg $250 2021-12-16 Buy
AK Scientific F477 Monoethyl fumarate >99%(GC) 1kg $299 2026-06-04 Buy
Ambeed A145377 (E)-4-Ethoxy-4-oxobut-2-enoicacid 98% 500g $87 2021-12-16 Buy

Properties

Melting point :66-68 °C (lit.)
Boiling point :147 °C/16 mmHg (lit.)
Density :1.1109
refractive index :1.4500 (estimate)
storage temp. :Refrigerator
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka :3.45±0.10(Predicted)
form :Crystalline Powder
color :Almost white to beige
Water Solubility :Soluble in water.
BRN :1723588
Dielectric constant :6.5(23.0℃)
InChI :InChI=1S/C6H8O4/c1-2-10-6(9)4-3-5(7)8/h3-4H,2H2,1H3,(H,7,8)/b4-3+
InChIKey :XLYMOEINVGRTEX-ONEGZZNKSA-N
SMILES :C(OCC)(=O)/C=C/C(O)=O
CAS DataBase Reference :2459-05-4(CAS DataBase Reference)
NIST Chemistry Reference :Ethyl hydrogen fumarate(2459-05-4)

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Monoethyl fumarate is the Monoethyl ester form of fumarate. It is a kind of effective preservative and polymerization agent for macromolecular material. Monoethyl fumarate is capable of inhibiting the growth of bacteria, yeast and mold and prolonging the storage time of feed can. It can also be used for long-term systemic therapy in the treatment of psoriasis (a chronic hyperproliferative inflammatory skin disorder). It is the most active ingredient in the antipsoriasis drug Fumadem. The mechanism is likely to be related to its effect of improvement of keratinocyte differentiation and inhibition of keratinocyte proliferation. Monomethyl fumarate has beneficial effects on the inflamed blood–brain barrier. It increases levels of endogenous antioxidant proteins in brain endothelial cells and reduces expression of VCAM-1 in inflamed brain endothelial cells. Transendothelial monocyte migration is limited upon MMF treatment.

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