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ChemicalBook >> CAS DataBase List >> Necrostatin-5

Necrostatin-5

$40 - $440
Product name: Necrostatin-5
CAS: 337349-54-9
MF: C19H17N3O2S2
MW: 383.49
EINECS:
MDL Number:MFCD01448275
Synonyms:Necrostatin-5;Necrostatin-5 (Nec-5);2-[[3,4,5,6,7,8-Hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile;3-p-methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide;Acetonitrile, 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-;Necrostatin-5 >=98% (HPLC), solid;Necrostatin5,Necrostatin 5;2-((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetonitrile

Price19 Properties Safety Information Description

19 prices

Selected condition：

Brand

aablocks
ACHEMBLOCK
Adipogen Life Sciences
AK Scientific
ApexBio Technology
Cayman Chemical
ChemScene
Sigma-Aldrich
Usbiological

Package

5mg
10mg
25mg
100MG

Manufactureraablocks
Product numberAA00CHII
Product description2-((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetonitrile ≥98%
Packaging5mg
Price$49
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00CHII
Product description2-((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetonitrile
Packaging10mg
Price$51
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00CHII
Product description2-((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetonitrile
Packaging25mg
Price$91
Updated2026-05-28
Buy

ManufacturerACHEMBLOCK
Product numberY228053
Product descriptionNecrostatin-5 97.00%
Packaging25MG
Price$125
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberY228053
Product descriptionNecrostatin-5 97.00%
Packaging100MG
Price$440
Updated2026-05-27
Buy

ManufacturerAdipogen Life Sciences
Product numberAG-CR1-0049-M025
Product descriptionNecrostatin-5 ≥98%(NMR)
Packaging25mg
Price$160
Updated2026-05-06
Buy

ManufacturerAdipogen Life Sciences
Product numberAG-CR1-0049-M005
Product descriptionNecrostatin-5 ≥98%(NMR)
Packaging5mg
Price$40
Updated2026-05-06
Buy

ManufacturerAK Scientific
Product number9562BA
Product descriptionNecrostatin-5
Packaging25mg
Price$337
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberBA3483
Product descriptionNecrostatin-5
Packaging25mg
Price$162
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberBA3483
Product descriptionNecrostatin-5
Packaging10mg
Price$72
Updated2026-05-06
Buy

ManufacturerCayman Chemical
Product number10527
Product descriptionNecrostatin-5 ≥98%
Packaging5mg
Price$54
Updated2026-04-30
Buy

ManufacturerCayman Chemical
Product number10527
Product descriptionNecrostatin-5 ≥98%
Packaging25mg
Price$238
Updated2026-04-30
Buy

ManufacturerChemScene
Product numberCS-0086886
Product descriptionNecrostatin-5 99.40%
Packaging25mg
Price$195
Updated2026-06-04
Buy

ManufacturerChemScene
Product numberCS-0086886
Product descriptionNecrostatin-5 99.40%
Packaging5mg
Price$54
Updated2026-06-04
Buy

ManufacturerChemScene
Product numberCS-0086886
Product descriptionNecrostatin-5 99.40%
Packaging10mg
Price$87
Updated2026-06-04
Buy

ManufacturerSigma-Aldrich
Product numberN0164
Product descriptionNecrostatin-5 ≥98% (HPLC), solid
Packaging5mg
Price$84.8
Updated2026-04-30
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA00CHII	2-((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetonitrile ≥98%	5mg	$49	2026-05-28	Buy
aablocks	AA00CHII	2-((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetonitrile	10mg	$51	2026-05-28	Buy
aablocks	AA00CHII	2-((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetonitrile	25mg	$91	2026-05-28	Buy
ACHEMBLOCK	Y228053	Necrostatin-5 97.00%	25MG	$125	2026-05-27	Buy
ACHEMBLOCK	Y228053	Necrostatin-5 97.00%	100MG	$440	2026-05-27	Buy
Adipogen Life Sciences	AG-CR1-0049-M025	Necrostatin-5 ≥98%(NMR)	25mg	$160	2026-05-06	Buy
Adipogen Life Sciences	AG-CR1-0049-M005	Necrostatin-5 ≥98%(NMR)	5mg	$40	2026-05-06	Buy
AK Scientific	9562BA	Necrostatin-5	25mg	$337	2021-12-16	Buy
ApexBio Technology	BA3483	Necrostatin-5	25mg	$162	2026-05-06	Buy
ApexBio Technology	BA3483	Necrostatin-5	10mg	$72	2026-05-06	Buy
Cayman Chemical	10527	Necrostatin-5 ≥98%	5mg	$54	2026-04-30	Buy
Cayman Chemical	10527	Necrostatin-5 ≥98%	25mg	$238	2026-04-30	Buy
ChemScene	CS-0086886	Necrostatin-5 99.40%	25mg	$195	2026-06-04	Buy
ChemScene	CS-0086886	Necrostatin-5 99.40%	5mg	$54	2026-06-04	Buy
ChemScene	CS-0086886	Necrostatin-5 99.40%	10mg	$87	2026-06-04	Buy
Sigma-Aldrich	N0164	Necrostatin-5 ≥98% (HPLC), solid	5mg	$84.8	2026-04-30	Buy

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Properties

Melting point :212-214℃
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :solid
color :white to off-white
InChI :1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3
InChIKey :VGONMECBFMCKBS-UHFFFAOYSA-N
SMILES :COc1ccc(cc1)N2C(=O)c3c4CCCCc4sc3N=C2SCC#N

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning		P264, P280, P305+P351+P338,P337+P313P
H413	May cause long lasting harmful effects to aquatic life	Hazardous to the aquatic environment, long-term hazard	Category 4

Precautionary statements:

P273	Avoid release to the environment.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand–induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

Necrostatin-5 CAS:337349-54-9

BOC Sciences Shanghai Tauto Biotech Co., Ltd. Shanghai EFE Biological Technology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd. Tianjin Kailiqi Biotechnology Co., Ltd. Shanghai Hongye Biotechnology Co. Ltd ChemeGen(Shanghai) Biotechnology Co.,Ltd. Zhejiang Huida Biotech Co., LTD Energy Chemical

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Necrostatin-5

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