SC-560
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- $13 - $2561
- Product name: SC-560
- CAS: 188817-13-2
- MF: C17H12ClF3N2O
- MW: 352.74
- EINECS:
- MDL Number:MFCD02179214
- Synonyms:SC-560;5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE;5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-TRIFLUOROMETHYLPYRAZOLE;SC-560 Assay Reagent;1H-Pyrazole, 5-(4-chlorophenyl)-1-(4-Methoxyphenyl)-3-(trifluoroMethyl)-;5-(4-Chlorophenyl)-3-(trifluoromethyl)-1-(4-methoxyphenyl)-1H-pyrazole;5-(4-Chlorophenyl);SC-560 - CAS 188817-13-2 - Calbiochem
61 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10mM(in 1mL DMSO)
- 1mg
- 10mM(in1mLDMSO)
- 5mg
- 10mg
- 10
- 25mg
- 50mg
- 100mg
- 250mg
- 1.00g
- 1000mg
- 1g
- 5G
- Manufactureraablocks
- Product numberAA002HAO
- Product description5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole 95%
- Packaging1mg
- Price$13
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002HAO
- Product description5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole 95%
- Packaging5mg
- Price$25
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002HAO
- Product description5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole 95%
- Packaging10mg
- Price$34
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002HAO
- Product description5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
- Packaging100mg
- Price$279
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002HAO
- Product description5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole ≥98%(HPLC)
- Packaging1g
- Price$1695
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51306
- Product descriptionSC-560 98%
- Packaging5G
- Price$1140
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51306
- Product descriptionSC-560 98%
- Packaging1G
- Price$315
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number1879BB
- Product description5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
- Packaging1g
- Price$2561
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA252197
- Product descriptionSC-560 95%
- Packaging1g
- Price$560
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA252197
- Product descriptionSC-560 95%
- Packaging5mg
- Price$23
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA252197
- Product descriptionSC-560 95%
- Packaging10mg
- Price$38
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA252197
- Product descriptionSC-560 95%
- Packaging25mg
- Price$63
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000997
- Product descriptionSC-560 95.00%
- Packaging1MG
- Price$561.51
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000997
- Product descriptionSC-560 95.00%
- Packaging5MG
- Price$646.69
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000997
- Product descriptionSC-560 95.00%
- Packaging25MG
- Price$822.24
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6786
- Product descriptionSC 560
- Packaging5mg
- Price$66
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA002HAO | 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole 95% | 1mg | $13 | 2026-05-28 | Buy |
| aablocks | AA002HAO | 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole 95% | 5mg | $25 | 2026-05-28 | Buy |
| aablocks | AA002HAO | 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole 95% | 10mg | $34 | 2026-05-28 | Buy |
| aablocks | AA002HAO | 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole | 100mg | $279 | 2026-05-28 | Buy |
| aablocks | AA002HAO | 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole ≥98%(HPLC) | 1g | $1695 | 2026-05-28 | Buy |
| ACHEMBLOCK | P51306 | SC-560 98% | 5G | $1140 | 2026-05-27 | Buy |
| ACHEMBLOCK | P51306 | SC-560 98% | 1G | $315 | 2026-05-27 | Buy |
| AK Scientific | 1879BB | 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole | 1g | $2561 | 2021-12-16 | Buy |
| Ambeed | A252197 | SC-560 95% | 1g | $560 | 2021-12-16 | Buy |
| Ambeed | A252197 | SC-560 95% | 5mg | $23 | 2021-12-16 | Buy |
| Ambeed | A252197 | SC-560 95% | 10mg | $38 | 2021-12-16 | Buy |
| Ambeed | A252197 | SC-560 95% | 25mg | $63 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000997 | SC-560 95.00% | 1MG | $561.51 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000997 | SC-560 95.00% | 5MG | $646.69 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000997 | SC-560 95.00% | 25MG | $822.24 | 2021-12-16 | Buy |
| ApexBio Technology | B6786 | SC 560 | 5mg | $66 | 2026-05-06 | Buy |
Properties
Melting point :63 °C
Boiling point :440.6±45.0 °C(Predicted)
Density :1.33
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
form :Off-white solid
pka :-3+-.0.10(Predicted)
color :White to Light yellow to Light orange
InChI :1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
InChIKey :PQUGCKBLVKJMNT-UHFFFAOYSA-N
SMILES :COc1ccc(cc1)-n2nc(cc2-c3ccc(Cl)cc3)C(F)(F)F
Boiling point :440.6±45.0 °C(Predicted)
Density :1.33
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
form :Off-white solid
pka :-3+-.0.10(Predicted)
color :White to Light yellow to Light orange
InChI :1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
InChIKey :PQUGCKBLVKJMNT-UHFFFAOYSA-N
SMILES :COc1ccc(cc1)-n2nc(cc2-c3ccc(Cl)cc3)C(F)(F)F
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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| Precautionary statements: |
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Description
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex?) and rofecoxib (Vioxx?). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect to COX-1 is 9 nM, while the corresponding IC50 value for COX-2 is 6.3 μM. Thus, SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat, where 10 mg/kg completely abolishes the ionophore-induced production of thromboxane B2 in whole blood. However, SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model, in which the COX-2 generated prostaglandins play a significant role in the inflammatory process. In whole cells, however, SC-560 appears to act as a non-selective COX inhibitor. The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated.More related product prices
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