SGX-523
|
- $15 - $4050
- Product name: SGX-523
- CAS: 1022150-57-7
- MF: C18H13N7S
- MW: 359.41
- EINECS:-0
- MDL Number:MFCD16660190
- Synonyms:SGX-523;6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline;SGX 523(SGX-523);Quinoline,6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-;6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline SGX 523;SGX-523, >=98%;6-[[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]quinoline;SGX-523;SGX523; SGX 523
73 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1000mg
- 10mM*1mLinDMSO
- 5g
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- 10g
- 10
- 50
- 50.00g
- 100.00g
- 250.00g
- 1mg
- 10mM(in1mLDMSO)
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- EvaluationSample
- Manufactureraablocks
- Product numberAA008TGP
- Product descriptionSGX-523 99%
- Packaging1mg
- Price$15
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TGP
- Product descriptionSGX-523 99%
- Packaging2mg
- Price$19
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TGP
- Product descriptionSGX-523 99%
- Packaging5mg
- Price$27
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TGP
- Product descriptionSGX-523 99%
- Packaging10mg
- Price$36
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TGP
- Product descriptionSGX-523 98%(HPLC)
- Packaging25mg
- Price$76
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TGP
- Product descriptionSGX-523 99%
- Packaging50mg
- Price$95
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TGP
- Product descriptionSGX-523 99%
- Packaging100mg
- Price$151
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TGP
- Product descriptionSGX-523 98%(HPLC)
- Packaging250mg
- Price$290
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008TGP
- Product descriptionSGX-523 95%
- Packaging1g
- Price$807
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberA-723
- Product descriptionSGX-523 98%
- Packaging1G
- Price$905
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberA-723
- Product descriptionSGX-523 98%
- Packaging250MG
- Price$300
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7475
- Product descriptionSGX-523
- Packaging25mg
- Price$345
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7475
- Product descriptionSGX-523
- Packaging50mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000484
- Product descriptionSGX-523 95.00%
- Packaging50MG
- Price$1552.32
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000484
- Product descriptionSGX-523 95.00%
- Packaging1MG
- Price$148.05
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1196
- Product descriptionSGX-523
- Packaging5mg
- Price$110
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA008TGP | SGX-523 99% | 1mg | $15 | 2026-05-28 | Buy |
| aablocks | AA008TGP | SGX-523 99% | 2mg | $19 | 2026-05-28 | Buy |
| aablocks | AA008TGP | SGX-523 99% | 5mg | $27 | 2026-05-28 | Buy |
| aablocks | AA008TGP | SGX-523 99% | 10mg | $36 | 2026-05-28 | Buy |
| aablocks | AA008TGP | SGX-523 98%(HPLC) | 25mg | $76 | 2026-05-28 | Buy |
| aablocks | AA008TGP | SGX-523 99% | 50mg | $95 | 2026-05-28 | Buy |
| aablocks | AA008TGP | SGX-523 99% | 100mg | $151 | 2026-05-28 | Buy |
| aablocks | AA008TGP | SGX-523 98%(HPLC) | 250mg | $290 | 2026-05-28 | Buy |
| aablocks | AA008TGP | SGX-523 95% | 1g | $807 | 2026-05-28 | Buy |
| ACHEMBLOCK | A-723 | SGX-523 98% | 1G | $905 | 2026-05-27 | Buy |
| ACHEMBLOCK | A-723 | SGX-523 98% | 250MG | $300 | 2026-05-27 | Buy |
| AK Scientific | X7475 | SGX-523 | 25mg | $345 | 2021-12-16 | Buy |
| AK Scientific | X7475 | SGX-523 | 50mg | $540 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000484 | SGX-523 95.00% | 50MG | $1552.32 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000484 | SGX-523 95.00% | 1MG | $148.05 | 2021-12-16 | Buy |
| ApexBio Technology | A1196 | SGX-523 | 5mg | $110 | 2026-05-06 | Buy |
Properties
Density :1.485
storage temp. :Store at -20°C
solubility :≥17.95 mg/mL in DMSO
form :solid
pka :3.94±0.10(Predicted)
color :Light yellow to yellow
InChI :InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3
InChIKey :BCZUAADEACICHN-UHFFFAOYSA-N
SMILES :N1C2C(=CC(SC3N4C(=NN=3)C=CC(C3=CN(C)N=C3)=N4)=CC=2)C=CC=1
storage temp. :Store at -20°C
solubility :≥17.95 mg/mL in DMSO
form :solid
pka :3.94±0.10(Predicted)
color :Light yellow to yellow
InChI :InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3
InChIKey :BCZUAADEACICHN-UHFFFAOYSA-N
SMILES :N1C2C(=CC(SC3N4C(=NN=3)C=CC(C3=CN(C)N=C3)=N4)=CC=2)C=CC=1
Safety Information
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| Signal word: | warning | ||||||||||||||||||||||||||||||||||||||
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Description
The hepatocyte growth factor receptor c-Met commonly shows elevated activity in several forms of cancer. SGX523 is a potent, selective, ATP-competitive inhibitor that blocks the tyrosine kinase activity of c-Met with an IC50 value of 4 nM. It is over 1,000-fold selective for c-Met over a panel of other kinases. SGX523 is orally active and dose-dependently inhibits the growth of a variety of tumor xenografts in mice. The effectiveness of SGX523 is enhanced when combined with other chemotherapeutic compounds, including inhibitors of EGFR. SGX523 is metabolized, at least in part, by aldehyde oxidase, an enzyme that differs in activity across different species.Related product price
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