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ChemicalBook >> CAS DataBase List >> TAK-632

TAK-632

$28 - $2691.1
Product name: TAK-632
CAS: 1228591-30-7
MF: C27H18F4N4O3S
MW: 554.52
EINECS:200-256-5
MDL Number:MFCD26960965
Synonyms:TAK-632;N-(7-CYANO-6-(4-FLUORO-3-(2-(3-(TRIFLUOROMETHYL)PHENYL)ACETAMIDO)PHENOXY)BENZO[D]THIAZOL-2-YL)CYCLOPROPANECARBOXAMIDE;N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide;CS-854;TAK 632; TAK632;TAK-0632;N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide TAK632;TAK 632 N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide

Price59 Properties Safety Information Description

59 prices

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aablocks
ACHEMBLOCK
Adipogen Life Sciences
AK Scientific
ApexBio Technology
Arctom
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Medical Isotopes, Inc.
TRC

Package

EvaluationSample
1unit
20mg
10mM(in1mLDMSO)
10mM*1mLinDMSO(Solid+Solvent)
10mM*1mLinDMSO
250mg
10mM*1mLinDMSO(Solution)
1000mg
1mg
5mg
10mg
25mg
1G
50mg
100mg
200mg
10mM(in 1mL DMSO)

Manufactureraablocks
Product numberAA000JJ9
Product descriptionN-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide ≥98%
Packaging1mg
Price$36
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000JJ9
Product descriptionN-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide
Packaging5mg
Price$48
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000JJ9
Product descriptionN-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide 98%
Packaging10mg
Price$51
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000JJ9
Product descriptionN-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide
Packaging25mg
Price$83
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000JJ9
Product descriptionN-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide
Packaging50mg
Price$121
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000JJ9
Product descriptionN-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide
Packaging100mg
Price$199
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000JJ9
Product descriptionN-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide
Packaging200mg
Price$252
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberO33834
Product descriptionTAK-632 98%
Packaging100MG
Price$295
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberO33834
Product descriptionTAK-632 98%
Packaging1G
Price$1250
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberO33834
Product descriptionTAK-632 98%
Packaging25MG
Price$120
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberO33834
Product descriptionTAK-632 98%
Packaging5MG
Price$45
Updated2026-05-27
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1203-M001
Product descriptionTAK-632 ≥95%
Packaging1mg
Price$76
Updated2026-05-06
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1203-M010
Product descriptionTAK-632 ≥95%
Packaging10mg
Price$184
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberSYN-1203-M005
Product descriptionTAK-632 ≥95%
Packaging5mg
Price$130
Updated2026-05-06
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1203-M100
Product descriptionTAK-632 ≥95%
Packaging100mg
Price$1069
Updated2021-12-16
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1203-M050
Product descriptionTAK-632 ≥95%
Packaging50mg
Price$702
Updated2026-05-06
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA000JJ9	N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide ≥98%	1mg	$36	2026-05-25	Buy
aablocks	AA000JJ9	N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide	5mg	$48	2026-05-25	Buy
aablocks	AA000JJ9	N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide 98%	10mg	$51	2026-05-25	Buy
aablocks	AA000JJ9	N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide	25mg	$83	2026-05-25	Buy
aablocks	AA000JJ9	N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide	50mg	$121	2026-05-25	Buy
aablocks	AA000JJ9	N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide	100mg	$199	2026-05-25	Buy
aablocks	AA000JJ9	N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide	200mg	$252	2026-05-25	Buy
ACHEMBLOCK	O33834	TAK-632 98%	100MG	$295	2026-05-27	Buy
ACHEMBLOCK	O33834	TAK-632 98%	1G	$1250	2026-05-27	Buy
ACHEMBLOCK	O33834	TAK-632 98%	25MG	$120	2026-05-27	Buy
ACHEMBLOCK	O33834	TAK-632 98%	5MG	$45	2026-05-27	Buy
Adipogen Life Sciences	SYN-1203-M001	TAK-632 ≥95%	1mg	$76	2026-05-06	Buy
Adipogen Life Sciences	SYN-1203-M010	TAK-632 ≥95%	10mg	$184	2026-05-06	Buy
Adipogen Life Sciences	SYN-1203-M005	TAK-632 ≥95%	5mg	$130	2026-05-06	Buy
Adipogen Life Sciences	SYN-1203-M100	TAK-632 ≥95%	100mg	$1069	2021-12-16	Buy
Adipogen Life Sciences	SYN-1203-M050	TAK-632 ≥95%	50mg	$702	2026-05-06	Buy

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Properties

Density :1.52±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥27.75 mg/mL in DMSO; insoluble in H2O; ≥2.23 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :9.59±0.70(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning		P264, P270, P301+P312, P330, P501

Precautionary statements:

P280	Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

TAK-632 is a slow off-rate inhibitor of Raf kinases (IC50s = 8.3, 2.4, and 1.4 nM for wild type B-Raf, mutant B-RafV600E, and c-Raf, respectively). It demonstrates 14-1,200-fold selectivity for Raf over a panel of 26 different kinases. TAK-632 shows significant antiproliferative activity against mutated B-Raf or mutated N-Ras cancer cell lines and xenograft models, inhibiting MEK phosphorylation with an IC50 value of 12 nM and downstream ERK phosphorylation with an IC50 value of 16 nM.

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Suppliers and manufacturers

Shanghai Boyle Chemical Co., Ltd. J & K SCIENTIFIC LTD. Shanghai Topbiochem Technology Co., Ltd NCE Biomedical Co.,Ltd. Haoyuan Chemexpress Co., Ltd. Guangzhou Isun Pharmaceutical Co., Ltd Bide Pharmatech Ltd. AdooQ Bioscience CHINA Shanghai JiYi Biotechnology Co. Ltd. Credit Asia Chemical Co., Ltd.

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TAK-632

Properties

Safety Information

Description

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