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ChemicalBook >> CAS DataBase List >> VX-745

VX-745

$20 - $5500
Product name: VX-745
CAS: 209410-46-8
MF: C19H9Cl2F2N3OS
MW: 436.26
EINECS:
MDL Number:MFCD09834070
Synonyms:6H-PYRIMIDO[1,6-B]PYRIDAZIN-6-ONE, 5-(2,6-DICHLOROPHENYL)-2-[(2,4-DIFLUOROPHENYL)THIO]- (9CI);6H-PYRIMIDO[1,6-B]PYRIDAZIN-6-ONE, 5-(2,6-DICHLOROPHENYL)-2-[(2,4-DIFLUOROPHENYL)THIO]-;5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-on;5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one;CS-1918;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylsulfanyl)-6H-pyriMido[3,4-b]pyridazin-6-one

Price68 Properties Safety Information Description

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aablocks
ACHEMBLOCK
Adipogen Life Sciences
AK Scientific
Ambeed
ApexBio Technology
Apolloscientific
Arctom
Axon Medchem
Biosynth
Cayman Chemical
Chemcia Scientific
ChemScene
Crysdot
CSNpharm
DC Chemicals
Matrix Scientific
Medical Isotopes, Inc.
Sigma-Aldrich
TRC
Usbiological

Package

10mM(in1mLDMSO)
1mg
2mg
2x5mg
10mM*1mLinDMSO
5mg
10mg
25mg
50mg
100mg
0.25G
250.00mg
250MG
500mg
1g
1.00g
2g
5G
10g

Manufactureraablocks
Product numberAA002K56
Product description5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one 98%
Packaging5mg
Price$32
Updated2026-05-28
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Manufactureraablocks
Product numberAA002K56
Product description5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one 98%
Packaging10mg
Price$51
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA002K56
Product description5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one 98%
Packaging25mg
Price$102
Updated2026-05-28
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Manufactureraablocks
Product numberAA002K56
Product description5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one 96
Packaging50mg
Price$194
Updated2026-05-28
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Manufactureraablocks
Product numberAA002K56
Product description5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one 96%
Packaging100mg
Price$382
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberY228676
Product descriptionNeflamapimod 97.00%
Packaging100MG
Price$370
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberY228676
Product descriptionNeflamapimod 97.00%
Packaging250MG
Price$740
Updated2026-05-27
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ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3754-M050
Product descriptionVX-745 ≥98%
Packaging50mg
Price$250
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3754-M005
Product descriptionVX-745 ≥98%
Packaging5mg
Price$50
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3754-M010
Product descriptionVX-745 ≥98%
Packaging10mg
Price$80
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberAG-CR1-3754-M001
Product descriptionVX-745 ≥98%
Packaging1mg
Price$20
Updated2026-05-06
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ManufacturerAK Scientific
Product numberSYN1123
Product descriptionVX745
Packaging1mg
Price$100
Updated2021-12-16
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ManufacturerAK Scientific
Product numberSYN1123
Product descriptionVX745
Packaging50mg
Price$640
Updated2021-12-16
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ManufacturerAmbeed
Product numberA189058
Product descriptionVX-745 98+%
Packaging50mg
Price$320
Updated2021-12-16
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ManufacturerAmbeed
Product numberA189058
Product descriptionVX-745 98+%
Packaging1g
Price$2370
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA189058
Product descriptionVX-745 98+%
Packaging10mg
Price$126
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA002K56	5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one 98%	5mg	$32	2026-05-28	Buy
aablocks	AA002K56	5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one 98%	10mg	$51	2026-05-28	Buy
aablocks	AA002K56	5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one 98%	25mg	$102	2026-05-28	Buy
aablocks	AA002K56	5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one 96	50mg	$194	2026-05-28	Buy
aablocks	AA002K56	5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one 96%	100mg	$382	2026-05-28	Buy
ACHEMBLOCK	Y228676	Neflamapimod 97.00%	100MG	$370	2026-05-27	Buy
ACHEMBLOCK	Y228676	Neflamapimod 97.00%	250MG	$740	2026-05-27	Buy
Adipogen Life Sciences	AG-CR1-3754-M050	VX-745 ≥98%	50mg	$250	2026-05-06	Buy
Adipogen Life Sciences	AG-CR1-3754-M005	VX-745 ≥98%	5mg	$50	2026-05-06	Buy
Adipogen Life Sciences	AG-CR1-3754-M010	VX-745 ≥98%	10mg	$80	2026-05-06	Buy
Adipogen Life Sciences	AG-CR1-3754-M001	VX-745 ≥98%	1mg	$20	2026-05-06	Buy
AK Scientific	SYN1123	VX745	1mg	$100	2021-12-16	Buy
AK Scientific	SYN1123	VX745	50mg	$640	2021-12-16	Buy
Ambeed	A189058	VX-745 98+%	50mg	$320	2021-12-16	Buy
Ambeed	A189058	VX-745 98+%	1g	$2370	2021-12-16	Buy
Ambeed	A189058	VX-745 98+%	10mg	$126	2021-12-16	Buy

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Properties

Melting point :261-264 °C
Boiling point :578.9±60.0 °C(Predicted)
Density :1.55±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥21.8 mg/mL in DMSO; insoluble in H2O; ≥2.1 mg/mL in EtOH with gentle warming and ultrasonic
form :powder
pka :-0.97±0.40(Predicted)
color :white to beige
InChI :1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
InChIKey :VEPKQEUBKLEPRA-UHFFFAOYSA-N
SMILES :FC1=C(SC2=NN(C=N3)C(C=C2)=C(C4=C(Cl)C=CC=C4Cl)C3=O)C=CC(F)=C1

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H332	Harmful if inhaled	Acute toxicity,inhalation	Category 4	Warning	P261, P271, P304+P340, P312
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

p38α is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonine protein kinases. It is widely expressed in endothelial, immune, and inflammatory cells and plays a central role in the regulation of proinflammatory cytokine production including TNF-α, IL-1β, and IL-6. VX-745 is a potent inhibitor of p38α MAPK (IC50 = 10 nM) with 20-fold selectivity over p38β and 1000-fold selectivity over closely related kinases, ERK1 and JNK1-3. It blocks IL-1β and TNF-α release in whole blood in vitro with IC50 values of 150 and 180 nM, respectively. VX-745 has been shown to demonstrate anti-inflammatory efficacy in an animal model of rheumatoid arthritis, but was discontinued in clinical trial due to adverse central nervous system effects.

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Suppliers and manufacturers

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VX-745

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