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ChemicalBook >> CAS DataBase List >> cis-4-Hydroxy-L-proline

cis-4-Hydroxy-L-proline

cis-4-Hydroxy-L-proline price.
  • $4 - $3787
  • Product name: cis-4-Hydroxy-L-proline
  • CAS: 618-27-9
  • MF: C5H9NO3
  • MW: 131.13
  • EINECS:210-542-1
  • MDL Number:MFCD00064319
  • Synonyms:L-ALLO-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID;L-ALLO-4-HYDROXY-2-PYRROLIDINECARBOXYLLIC ACID;L-ALLO-HYDROXYPROLINE;CIS-4-HYDROXY-L-PROLINE;CIS-L-4-HYDROXYPROLINE;CHYP;HYDROXY-L-PROLINE [ALLO];H-PRO(CIS-4-OH)-OH
Price91 Properties Safety Information Description
91 prices
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  • aablocks
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  • Manufactureraablocks
  • Product numberAA0036ZL
  • Product description(2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid 98%
  • Packaging250mg
  • Price$4
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0036ZL
  • Product description(2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid 97%
  • Packaging1g
  • Price$6
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0036ZL
  • Product description(2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid 98%
  • Packaging5g
  • Price$13
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0036ZL
  • Product description(2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid 98%
  • Packaging10g
  • Price$19
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0036ZL
  • Product description(2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid 98%
  • Packaging25g
  • Price$42
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA0036ZL
  • Product description(2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid 98%
  • Packaging100g
  • Price$156
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberO30697
  • Product description(2S,4S)-4-hydroxypyrrolidine-2-carboxylicacid 95%
  • Packaging5G
  • Price$95
  • Updated2021-12-16
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  • ManufacturerACHEMBLOCK
  • Product numberO30697
  • Product description(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid 95%
  • Packaging100G
  • Price$230
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberO30697
  • Product description(2S,4S)-4-hydroxypyrrolidine-2-carboxylicacid 95%
  • Packaging25G
  • Price$285
  • Updated2021-12-16
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  • ManufacturerActivate Scientific
  • Product numberAS3728-A
  • Product descriptionCis-4-Hydroxy-L-proline 98+%
  • Packaging1g
  • Price$42
  • Updated2021-12-16
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  • ManufacturerAHH
  • Product numberMT-15523
  • Product descriptioncis-4-Hydroxy-L-proline 97%
  • Packaging10g
  • Price$635
  • Updated2026-05-26
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  • ManufacturerAK Scientific
  • Product numberJ93503
  • Product descriptioncis-4-Hydroxy-L-proline
  • Packaging100g
  • Price$650
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberJ93503
  • Product descriptioncis-4-Hydroxy-L-proline
  • Packaging1g
  • Price$25
  • Updated2021-12-16
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  • ManufacturerAlichem
  • Product number618279
  • Product description(2S,4S)-4-Hydroxypyrrolidine-2-carboxylicacid
  • Packaging25g
  • Price$551.2
  • Updated2021-12-16
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  • ManufacturerAlichem
  • Product number618279
  • Product description(2S,4S)-4-Hydroxypyrrolidine-2-carboxylicacid
  • Packaging10g
  • Price$262.6
  • Updated2021-12-16
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  • ManufacturerAlichem
  • Product number618279
  • Product description(2S,4S)-4-Hydroxypyrrolidine-2-carboxylicacid
  • Packaging100g
  • Price$1462.8
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA0036ZL (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid 98% 250mg $4 2026-05-28 Buy
aablocks AA0036ZL (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid 97% 1g $6 2026-05-28 Buy
aablocks AA0036ZL (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid 98% 5g $13 2026-05-28 Buy
aablocks AA0036ZL (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid 98% 10g $19 2026-05-28 Buy
aablocks AA0036ZL (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid 98% 25g $42 2026-05-28 Buy
aablocks AA0036ZL (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid 98% 100g $156 2026-05-28 Buy
ACHEMBLOCK O30697 (2S,4S)-4-hydroxypyrrolidine-2-carboxylicacid 95% 5G $95 2021-12-16 Buy
ACHEMBLOCK O30697 (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid 95% 100G $230 2026-05-27 Buy
ACHEMBLOCK O30697 (2S,4S)-4-hydroxypyrrolidine-2-carboxylicacid 95% 25G $285 2021-12-16 Buy
Activate Scientific AS3728-A Cis-4-Hydroxy-L-proline 98+% 1g $42 2021-12-16 Buy
AHH MT-15523 cis-4-Hydroxy-L-proline 97% 10g $635 2026-05-26 Buy
AK Scientific J93503 cis-4-Hydroxy-L-proline 100g $650 2021-12-16 Buy
AK Scientific J93503 cis-4-Hydroxy-L-proline 1g $25 2021-12-16 Buy
Alichem 618279 (2S,4S)-4-Hydroxypyrrolidine-2-carboxylicacid 25g $551.2 2021-12-16 Buy
Alichem 618279 (2S,4S)-4-Hydroxypyrrolidine-2-carboxylicacid 10g $262.6 2021-12-16 Buy
Alichem 618279 (2S,4S)-4-Hydroxypyrrolidine-2-carboxylicacid 100g $1462.8 2021-12-16 Buy
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Properties

Melting point :257 °C (dec.) (lit.)
alpha :-59 º (c=2, H2O)
Boiling point :242.42°C (rough estimate)
Density :1.3121 (rough estimate)
refractive index :-59 ° (C=2, H2O)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :soluble
form :Powder
pka :2.14±0.40(Predicted)
color :White to beige
Water Solubility :soluble
Merck :14,4840
BRN :81440
Major Application :peptide synthesis
InChI :1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4-/m0/s1
InChIKey :PMMYEEVYMWASQN-IMJSIDKUSA-N
SMILES :O[C@@H]1CN[C@@H](C1)C(O)=O
CAS DataBase Reference :618-27-9(CAS DataBase Reference)
EPA Substance Registry System :L-Proline, 4-hydroxy-, (4S)- (618-27-9)

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

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Suppliers and manufacturers

Wuhan EnTai Technology Development Co,.Ltd J & K SCIENTIFIC LTD. Meryer (Shanghai) Chemical Technology Co., Ltd. Alfa Aesar TCI (Shanghai) Development Co., Ltd. ShangHai DEMO Chemical Co.,Ltd Energy Chemical Capot Chemical Co., Ltd Beijing Ouhe Technology Co., Ltd Pure Chemistry Scientific Inc.