BI-6C9
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2物価
選択条件：
ブランド
- Sigma-Aldrich Japan
パッケージ
- 1mg
- 5mg
- 生産者Sigma-Aldrich Japan
- 製品番号B0186
- 製品説明 ≥97% (HPLC), solid
- 英語製品説明BI-6C9 ≥97% (HPLC), solid
- 包装単位1mg
- 価格￥19200
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号B0186
- 製品説明 ≥97% (HPLC), solid
- 英語製品説明BI-6C9 ≥97% (HPLC), solid
- 包装単位5mg
- 価格￥64800
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | B0186 | ≥97% (HPLC), solid BI-6C9 ≥97% (HPLC), solid |
1mg | ￥19200 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | B0186 | ≥97% (HPLC), solid BI-6C9 ≥97% (HPLC), solid |
5mg | ￥64800 | 2024-03-01 | 購入 |
プロパティ
比重(密度) :1.36±0.1 g/cm3(Predicted)
貯蔵温度 :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解性 :DMSO: 24 mg/mL, soluble
外見 :solid
酸解離定数(Pka) :11.58±0.50(Predicted)
色 :off-white
InChI :1S/C23H25N3O4S2/c1-30-19-8-14-22(15-9-19)32(28,29)25-16-2-3-23(27)26-18-6-12-21(13-7-18)31-20-10-4-17(24)5-11-20/h4-15,25H,2-3,16,24H2,1H3,(H,26,27)
InChIKey :LCFUJBSKPDPGKO-UHFFFAOYSA-N
SMILES :COc1ccc(cc1)S(=O)(=O)NCCCC(=O)Nc2ccc(Sc3ccc(N)cc3)cc2
貯蔵温度 :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解性 :DMSO: 24 mg/mL, soluble
外見 :solid
酸解離定数(Pka) :11.58±0.50(Predicted)
色 :off-white
InChI :1S/C23H25N3O4S2/c1-30-19-8-14-22(15-9-19)32(28,29)25-16-2-3-23(27)26-18-6-12-21(13-7-18)31-20-10-4-17(24)5-11-20/h4-15,25H,2-3,16,24H2,1H3,(H,26,27)
InChIKey :LCFUJBSKPDPGKO-UHFFFAOYSA-N
SMILES :COc1ccc(cc1)S(=O)(=O)NCCCC(=O)Nc2ccc(Sc3ccc(N)cc3)cc2
安全情報
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| 注意喚起語: | Warning | |||||||||||||||||||||||||||||||||||
| 危険有害性情報: |
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| 注意書き: |
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説明
BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 μM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 μM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.関連製品価格
BI-6C9関連商品価格
- BI-6C9
￥19200-64800
供給者とメーカー
Shanghai EFE Biological Technology Co., Ltd.
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Shanghai Hongye Biotechnology Co. Ltd
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InvivoChem
Shanghai Dongyang Biotechnology Co., Ltd.
Shanghai hongqu biomedical technology co. LTD
MedBioPharmaceutical Technology Inc