MPEP塩酸塩
|
- ￥22400 - ￥218000
- 化学名: MPEP塩酸塩
- 英語名: Mpep hydrochloride
- 別名:MPEP塩酸塩;6-メチル-2-(フェニルエチニル)ピリジン 塩酸塩
- CAS番号: 219911-35-0
- 分子式: C14H11N.ClH
- 分子量: 229.709
- EINECS:
- MDL Number:MFCD02262119
4物価
選択条件：
ブランド
- 富士フイルム和光純薬株式会社(wako)
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 10mg
- 25mg
- 50mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC1212
- 製品説明MPEP塩酸塩
- 英語製品説明MPEP hydrochloride
- 包装単位10mg
- 価格￥53000
- 更新しました2024-03-01
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC1212
- 製品説明MPEP塩酸塩
- 英語製品説明MPEP hydrochloride
- 包装単位50mg
- 価格￥218000
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号M5435
- 製品説明6-メチル-2-(フェニルエチニル)ピリジン 塩酸塩 ≥98% (HPLC)
- 英語製品説明6-Methyl-2-(phenylethynyl)pyridine hydrochloride ≥98% (HPLC)
- 包装単位5mg
- 価格￥22400
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号M5435
- 製品説明6-メチル-2-(フェニルエチニル)ピリジン 塩酸塩 ≥98% (HPLC)
- 英語製品説明6-Methyl-2-(phenylethynyl)pyridine hydrochloride ≥98% (HPLC)
- 包装単位25mg
- 価格￥71700
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式会社(wako) | W01TOC1212 | MPEP塩酸塩 MPEP hydrochloride |
10mg | ￥53000 | 2024-03-01 | 購入 |
| 富士フイルム和光純薬株式会社(wako) | W01TOC1212 | MPEP塩酸塩 MPEP hydrochloride |
50mg | ￥218000 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | M5435 | 6-メチル-2-(フェニルエチニル)ピリジン 塩酸塩 ≥98% (HPLC) 6-Methyl-2-(phenylethynyl)pyridine hydrochloride ≥98% (HPLC) |
5mg | ￥22400 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | M5435 | 6-メチル-2-(フェニルエチニル)ピリジン 塩酸塩 ≥98% (HPLC) 6-Methyl-2-(phenylethynyl)pyridine hydrochloride ≥98% (HPLC) |
25mg | ￥71700 | 2024-03-01 | 購入 |
プロパティ
融点 :145-146℃
貯蔵温度 :room temp
溶解性 :DMSO: 10 mg/mL
外見 :solid
色 :off-white
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChI :1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
InChIKey :PKDHDJBNEKXCBI-UHFFFAOYSA-N
SMILES :Cl.Cc1cccc(n1)C#Cc2ccccc2
貯蔵温度 :room temp
溶解性 :DMSO: 10 mg/mL
外見 :solid
色 :off-white
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChI :1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
InChIKey :PKDHDJBNEKXCBI-UHFFFAOYSA-N
SMILES :Cl.Cc1cccc(n1)C#Cc2ccccc2
安全情報
| 絵表示(GHS): |
 
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| 危険有害性情報: |
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説明
Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7 and 8) inhibit adenylyl cyclase. MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 μM. MPEP is centrally active following systemic administration in vivo, inducing anxiolytic-like effects in rodent models of anxiety and depression when administered at 1-30 mg/kg. MPEP has also been reported as a positive allosteric modulator of mGluR4 at μM concentrations.関連商品価格
- ピリジン
￥1210-341000 - p-トルエンスルホニルクロリド
￥1300-127900 - 2-フェニルピリジン
￥3600-1341700