| | 75747-14-7 Basic information More.. |
| Product Name: | 17-AAG | | Synonyms: | GELDANAMYCIN,17-DEMETHOXY-17-(2-PROPENYLAMINO)-;CP 127374;ALLYLAMINOGELDANAMYCIN;NSC-330507;17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN;17-(ALLYLAMINO)-17-DESMETHOXYGELDANAMYCIN;17-(ALLYLAMINO)-17-DIMETHOXYGELDANAMYCIN;17-ALLYLAMINOGELDANAMYCIN | | CAS: | 75747-14-7 | | MF: | C31H43N3O8 | | MW: | 585.69 | | EINECS: | | | Mol File: | 75747-14-7.mol |  |
Use
Geldanamycin is a potent inhibitor of Hsp90 that exhibits severe hepatotoxicity when used in vivo. 17-AAG is an analog of geldanamycin which has potent in vivo activity and reduced toxicity. Like other Hsp90 inhibitors, 17-AAG has diverse anti-tumor actions and has potential in treating certain types of cancer. 17-AAG inhibits the growth of prostate cancer cell lines (IC50 = 25-45 nM). 17-AAG promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).
- 17-AAG
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- US $0.00-0.00 / KG
- 2025-10-23
- CAS:75747-14-7
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 20TONS
- Tanespimycin
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- US $59.00-97.00 / mg
- 2025-10-22
- CAS:75747-14-7
- Min. Order:
- Purity: 99.56%
- Supply Ability: 10g
- 17-AAG
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- US $1.00 / KG
- 2020-01-03
- CAS:75747-14-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200kg
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75747-14-7
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