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| | 4-(3-fluoro-benzyloxy)-benzaldehyde Basic information |
| Product Name: | 4-(3-fluoro-benzyloxy)-benzaldehyde | | Synonyms: | Benzaldehyde, 4-[(3 -fluorophenyl)Methoxy]-;4-[(3-fluorophenyl)methoxy]-Benzaldehyde;Safinamide mesylate Intermediate;Safinamide mesylate
Intermediate 1;4-(3-FLUORO-BENZYLOXY)-BENZALDEHYDE
Intermediate 1;4-(3-Fluorobenzyloxy)benzaldehyde >;Safinamide Intermediate 1;4-(3-FLUORO-BENZYLOXY)-BENZALDEHYDE ISO 9001：2015 REACH | | CAS: | 66742-57-2 | | MF: | C14H11FO2 | | MW: | 230.23 | | EINECS: | 613-982-6 | | Product Categories: | Intermediate | | Mol File: | 66742-57-2.mol |  |
| | 4-(3-fluoro-benzyloxy)-benzaldehyde Chemical Properties |
| Melting point | 46.0 to 50.0 °C | | Boiling point | 265°C/3mmHg(lit.) | | density | 1.211±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | soluble in Methanol | | form | Solid:crystalline | | color | White to Almost white | | InChI | InChI=1S/C14H11FO2/c15-13-3-1-2-12(8-13)10-17-14-6-4-11(9-16)5-7-14/h1-9H,10H2 | | InChIKey | DNKSIIHRKWTIRH-UHFFFAOYSA-N | | SMILES | C(=O)C1=CC=C(OCC2=CC=CC(F)=C2)C=C1 | | CAS DataBase Reference | 66742-57-2 |
| HS Code | 2913.00.4000 | | HazardClass | IRRITANT |
| | 4-(3-fluoro-benzyloxy)-benzaldehyde Usage And Synthesis |
| Chemical Properties | 4-(3-fluorobenzyloxy)benzaldehyde is white to off-white solid at room temperature and pressure, it is a benzaldehyde derivative, and it is easy to be oxidized by air to produce the corresponding benzoic acid compounds when stored for a long time at room temperature, therefore, it is generally required to be stored under low temperature (2 to 8 degrees). | | Uses | 4-(3-Fluorobenzyloxy)benzaldehyde is useful for organic reactions and synthesis. | | Synthesis | 4-(3-fluoro-benzyloxy)-benzaldehyde is synthesized by the reaction of 4-Hydroxybenzaldehyde with 3-fluorobenzyl bromide. 4-Hydroxybenzaldehyde, 3-fluorobenzyl bromide, potassium carbonate, and acetone were sequentially added to a single-neck round bottom flask. Reaction at 60 ° C for 5 h. Cool to room temperature, filter, and collect the filtrate.Purification by direct column chromatography. 4-(3-fluoro-benzyloxy)-benzaldehyde was obtained as a white solid (1.78 g, 94.4%).
 | | References | [1] Patent: WO2009/74478, 2009, A1. Location in patent: Page/Page column 80-81
[2] Patent: WO2009/74478, 2009, A1. Location in patent: Page/Page column 81
[3] Patent: WO2007/147491, 2007, A1. Location in patent: Page/Page column 44-45
[4] Patent: WO2009/74478, 2009, A1. Location in patent: Page/Page column 57-58
[5] Patent: CN106220525, 2016, A. Location in patent: Paragraph 0013; 0014; 0019 |
| | 4-(3-fluoro-benzyloxy)-benzaldehyde Preparation Products And Raw materials |
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