Propanamide, 3,3'-(octylimino)bis[N-phenyl- manufacturers
- UCM-1336
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- $41.00
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2026-08-08
- CAS:1621535-90-7
- Purity: 98.86%
- Supply Ability: 10g
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| | Propanamide, 3,3'-(octylimino)bis[N-phenyl- Basic information |
| Product Name: | Propanamide, 3,3'-(octylimino)bis[N-phenyl- | | Synonyms: | Propanamide, 3,3'-(octylimino)bis[N-phenyl-;3,3′-(Octylimino)bis[N-phenylpropanamide];UCM-1336;UCM 1336,UCM1336;3,3'-(Octylazanediyl)bis(N-phenylpropanamide);UCM-1336, 10 mM in DMSO;3,3'-(Octylazanediyl)bis(N-phenylpropanamide) | | CAS: | 1621535-90-7 | | MF: | C26H37N3O2 | | MW: | 423.59 | | EINECS: | | | Product Categories: | | | Mol File: | 1621535-90-7.mol |  |
| | Propanamide, 3,3'-(octylimino)bis[N-phenyl- Chemical Properties |
| Boiling point | 644.2±40.0 °C(Predicted) | | density | 1.089±0.06 g/cm3(Predicted) | | pka | 14.43±0.70(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | Propanamide, 3,3'-(octylimino)bis[N-phenyl- Usage And Synthesis |
| Description | UCM-1336 is a potent isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor ( IC50 = 2 μM). UCM-1336 improves survival in Ras-driven acute myeloid leukemia. UCM-1336 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. In addition, it induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia. | | Uses | UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis[1]. | | References | [1] Nagore Marín-RamosA, Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia. J Med Chem. 2019 Jul 11;62(13):6035-6046. DOI:10.1021/acs.jmedchem.9b00145 |
| | Propanamide, 3,3'-(octylimino)bis[N-phenyl- Preparation Products And Raw materials |
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