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| | Benzoic acid, 4-cyano-, hydrazide (9CI) Basic information |
| Product Name: | Benzoic acid, 4-cyano-, hydrazide (9CI) | | Synonyms: | Benzoic acid, 4-cyano-, hydrazide (9CI);4-cyanobenzohydrazide(SALTDATA: FREE);4-Cyanobenzoylhydrazine;4-Cyan-benzoesaeure-hydrazid;4-cyano-benzhydrazide;4-cyanobenzoic acid hydrazide;4-cyano-benzoic acid hydrazide;4-cyanobenzoic hydrazide | | CAS: | 43038-36-4 | | MF: | C8H7N3O | | MW: | 161.16 | | EINECS: | | | Product Categories: | AMIDE | | Mol File: | 43038-36-4.mol |  |
| | Benzoic acid, 4-cyano-, hydrazide (9CI) Chemical Properties |
| Melting point | 202-203 °C | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 11+-.0.10(Predicted) | | Appearance | White to off-white Solid |
| | Benzoic acid, 4-cyano-, hydrazide (9CI) Usage And Synthesis |
| Synthesis | Part A. Synthesis of 4-cyanobenzoic acid hydrazide
A mixture of methyl 4-cyanobenzoate (10.8 g, 67 mmol) and hydrazine monohydrate (18.6 g, 371 mmol) in anhydrous ethanol (70 mL) was heated to reflux for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature. The solid product formed was collected by filtration and washed with cold ethanol (20 mL). Subsequently, the product was dried to give 4-cyanobenzoylhydrazine (8.7 g, 81% yield). The melting point of the product was 201 °C. 1H NMR (300 MHz, CDCl3) δ 4.14 (s, 2H), 7.40 (s, 1H), 7.76 (d, J = 8 Hz, 2H), 7.88 (d, J = 8 Hz, 2H); MS (NH3-Cl) calculated value (M + 1)+: 162, measured value: 162. | | References | [1] Bollettino Chimico Farmaceutico, 1999, vol. 138, # 8, p. 432 - 436
[2] Patent: US5668159, 1997, A
[3] Patent: WO2012/76898, 2012, A1. Location in patent: Page/Page column 71
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 3012 - 3023
[5] Patent: WO2010/139966, 2010, A1. Location in patent: Page/Page column 123 |
| | Benzoic acid, 4-cyano-, hydrazide (9CI) Preparation Products And Raw materials |
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