4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride

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4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride manufacturers

  • Enpp-1-IN-14
  • Enpp-1-IN-14 pictures
  • $51.00
  • 2026-07-14
  • CAS:2687222-59-7
  • Purity: 99.83%
  • Supply Ability: 10g
4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride Basic information
Product Name:4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride
Synonyms:4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride;Enpp-1-IN-14;Enpp-1-IN-14, 10 mM in DMSO
CAS:2687222-59-7
MF:C15H22ClN5O4S
MW:403.88
EINECS:
Product Categories:
Mol File:2687222-59-7.mol
4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride Structure
4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride Chemical Properties
storage temp. Store at -20°C
solubility DMSO : 9.62 mg/mL (23.82 mM; Need ultrasonic)
form Solid
color White to off-white
Safety Information
MSDS Information
4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride Usage And Synthesis
UsesEnpp-1-IN-14 (Compound 015) is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC50 value of 32.38 nM for recombinant human ENPP-1. Enpp-1-IN-14 has anti-tumor activity[1].
in vivo

Enpp-1-IN-14 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth[1].

Animal Model:Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells)[1]
Dosage:50 mg/kg
Administration:IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site)
Result:Significantly inhibited tumor growth.
References[1] Srinivas Rao Kasibhatla, et al. Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (enpp1) and methods of use thereof. WO2021158829A1.
4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride Preparation Products And Raw materials
Tag:4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride(2687222-59-7) Related Product Information
4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride N-{2-[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]ethyl}sulfuric diamide Sulfamide, N-[2-[1-(2-amino-6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]ethyl]- 1H-1,4-Diazepine-1-sulfonamide, 4-(6,7-dimethoxy-4-quinazolinyl)hexahydro- N-{[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]methyl}sulfuric diamide Sulfamide, N-[2-[1-(7,8-dimethoxyimidazo[1,2-a]quinazolin-5-yl)-4-piperidinyl]ethyl]-