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| | 5-Oxaspiro[3.4]octane-7,8-diol, 6-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, (1R,4R,6R,7R,8S)- Basic information |
| Product Name: | 5-Oxaspiro[3.4]octane-7,8-diol, 6-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, (1R,4R,6R,7R,8S)- | | Synonyms: | 5-Oxaspiro[3.4]octane-7,8-diol, 6-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, (1R,4R,6R,7R,8S)-;PRMT5-IN-11 | | CAS: | 2567564-33-2 | | MF: | C13H17N5O4 | | MW: | 307.31 | | EINECS: | | | Product Categories: | | | Mol File: | 2567564-33-2.mol | ![5-Oxaspiro[3.4]octane-7,8-diol, 6-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, (1R,4R,6R,7R,8S)- Structure](CAS/20210305/GIF/2567564-33-2.gif) |
| | 5-Oxaspiro[3.4]octane-7,8-diol, 6-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, (1R,4R,6R,7R,8S)- Chemical Properties |
| Boiling point | 691.8±65.0 °C(Predicted) | | density | 2.00±0.1 g/cm3(Predicted) | | pka | 13.10±0.70(Predicted) |
| | 5-Oxaspiro[3.4]octane-7,8-diol, 6-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, (1R,4R,6R,7R,8S)- Usage And Synthesis |
| Uses | PRMT5-IN-11 is a promising structure-dependent inhibition of the protein methyltransferase PRMT5:MEP50 complex in the (sub)micromolar range. | | References | [1] Jouffroy L, et al. Regio- and Stereoselective Synthesis of C-4' Spirocyclobutyl Ribofuranose Scaffolds and Their Use as Biologically Active Nucleoside Analogues. Org Lett. 2021 Nov 19;23(22):8828-8833. DOI:10.1021/acs.orglett.1c03334 |
| | 5-Oxaspiro[3.4]octane-7,8-diol, 6-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, (1R,4R,6R,7R,8S)- Preparation Products And Raw materials |
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Tag:5-Oxaspiro[3.4]octane-7,8-diol, 6-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, (1R,4R,6R,7R,8S)-(2567564-33-2)
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