N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide

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N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide Suppliers list
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N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide manufacturers

  • TNG-462
  • TNG-462 pictures
  • $283.00
  • 2026-07-17
  • CAS:2760483-96-1
  • Purity: 99.59%
  • Supply Ability: 10g
N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide Basic information
Product Name:N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide
Synonyms:N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide;N-(6-Amino-5-ethyl-3-pyridyl)-2-[(2R,5S)-5-methyl-2-[2-(1-methyl-4-piperidyl)benzo[d]thiazol-5-yl]-1-piperidyl]-2-oxoacetamide;(2R,5S)-N-(6-Amino-5-ethyl-3-pyridinyl)-5-methyl-2-[2-(1-methyl-4-piperidinyl)-5-benzothiazolyl]-α-oxo-1-piperidineacetamide;1-Piperidineacetamide, N-(6-amino-5-ethyl-3-pyridinyl)-5-methyl-2-[2-(1-methyl-4-piperidinyl)-5-benzothiazolyl]-α-oxo-, (2R,5S)-;N-(6-amino-5-ethyl-3-pyridyl)-2-[(2R,5S)-5-methyl-2-[2-(1-methyl-4-piperidyl)-1,3-benzothiazol-5-yl]-1-piperidyl]-2-oxo-acetamide;vopimetostat;Vopimetostat (TNG-462)
CAS:2760483-96-1
MF:C28H36N6O2S
MW:520.69
EINECS:
Product Categories:
Mol File:2760483-96-1.mol
N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide Structure
N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide Chemical Properties
density 1.266±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
form Solid
pka11.337±0.70(predicted)
color White to off-white
InChIKeyDHAGMIPSRSPWSH-GAJHUEQPSA-N
SMILESC(N1C[C@H](CC[C@@H]1C1=CC=C2SC(C3CCN(CC3)C)=NC2=C1)C)(=O)C(=O)NC1=CN=C(C(=C1)CC)N
Safety Information
MSDS Information
N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide Usage And Synthesis
UsesTNG-462 is an orally active and selective PRMT5 inhibitor with anti-tumor activity against methylthioadenosine phosphorylase (MTAP) deficiency and/or methylthioadenosine (MTA) accumulation cancers[1][2].
in vivo

TNG-462 (40, 100 mg/kg; once daily (100 mg/kg) or b.i.d (40 mg/kg); 21 days; p.o.) has anti-tumor activity in a xenograft mouse model derived from MTAP deficient cell lines[1]. TNG-462 (30 mg/kg; twice daily; 5 weeks; p.o.) in combination with osimertinib (EGFR inhibitor) (HY-15772) (1 mg/kg; once daily; 5 weeks) has synergistic anti-tumor activity in MTAP-deficient cell line-derived xenograft mouse model[1].

Animal Model:LU99 MTAP-null cell line-derived xenograft mice model[1].
Dosage:40, 100 mg/kg
Administration:Oral gavage (p.o.); once daily (100 mg/kg) or b.i.d (40 mg/kg); 21 days
Result:Inhibited the growth of tumor volume.
References[1] Briggs K, et al. TNG462 is a potential best-in-class MTA-cooperative PRMT5 inhibitor for the treatment of MTAP-deleted solid tumors[J]. Cancer Research, 2023, 83(7_Supplement): 4970-4970.
[2] Kevin M Cottrell, et al. Piperidin-1- yl-n-pyrydi ne-3-yl-2-oxoacet am ide derivatives useful for the treatment of mtap-deficient and/or mt a-accumulating cancers. Patent WO2022026892A1.
N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide Preparation Products And Raw materials
Tag:N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide(2760483-96-1) Related Product Information
1-Piperidineacetamide, N-(6-amino-5-methyl-3-pyridinyl)-2-(5-benzothiazolyl)-5-methyl-α-oxo-, (2R,5S)- 1-Piperidineacetamide, N-(6-amino-5-methyl-3-pyridinyl)-2-(5-benzothiazolyl)-5-methyl-α-oxo-, (2S,5R)- N-(6-amino-5-ethylpyridin-3-yl)-2-((2R,5S)-5-methyl-2-(2-(1-methylpiperidin-4-yl)benzo[d]thiazol-5-yl)piperidin-1-yl)-2-oxoacetamide UNC 1999 EPZ015666 GSK-3326595