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| | 5-Chloro-1,6-naphthyridine Basic information |
| | 5-Chloro-1,6-naphthyridine Chemical Properties |
| Melting point | 106-107℃ | | Boiling point | 307.9±22.0 °C(Predicted) | | density | 1.349±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 2.04±0.30(Predicted) | | Appearance | Off-white to yellow Solid | | CAS DataBase Reference | 23616-32-2 |
| | 5-Chloro-1,6-naphthyridine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 5-chloro[1,6]diazanaphthalene from 1,6-naphthopyridin-5(6H)-one: the product of Example 36d (0.250 g, 1.71 mmol) was mixed with phosphorus trichloride (4 mL) and reacted under nitrogen protection at 80 °C for 18.5 hours. Upon completion of the reaction, the volatiles were removed by vacuum distillation. The residue was slurried with ice water and adjusted to pH 7-8 with concentrated ammonium hydroxide solution.5-Chloro[1,6]diazanaphthalene was collected by vacuum filtration, washed with water and dried under vacuum to give a gray solid (0.245 g, 87% yield) of sufficient purity to be used in subsequent separations. | | References | [1] Patent: WO2008/133753, 2008, A2. Location in patent: Page/Page column 81 |
| | 5-Chloro-1,6-naphthyridine Preparation Products And Raw materials |
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