2(3H)-Benzoxazolone, 3-[(3-methoxyphenyl)methyl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)-

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2(3H)-Benzoxazolone, 3-[(3-methoxyphenyl)methyl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)- Basic information
Product Name:2(3H)-Benzoxazolone, 3-[(3-methoxyphenyl)methyl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)-
Synonyms:2(3H)-Benzoxazolone, 3-[(3-methoxyphenyl)methyl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)-;3-(3-methoxybenzyl)-6-(3H-pyrrolo[2,3-b]pyridin-5-yl)benzo[d]oxazol-2(3H)-one;3-(3-methoxybenzyl)-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzo[d]oxazol-2(3H)-one;inhibit,Colorectal cancer,TNIK,Wnt,Cell proliferation,Inhibitor,TNIKIN5,Wnt pathway,Migration,HCT116?cells,TNIK IN 5;TNIK-IN-5
CAS:2754265-66-0
MF:C22H17N3O3
MW:371.39
EINECS:
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Mol File:2754265-66-0.mol
2(3H)-Benzoxazolone, 3-[(3-methoxyphenyl)methyl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)- Structure
2(3H)-Benzoxazolone, 3-[(3-methoxyphenyl)methyl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)- Chemical Properties
density 1.373±0.06 g/cm3(Predicted)
pka13.56±0.40(Predicted)
form Solid
color White to light yellow
Safety Information
MSDS Information
2(3H)-Benzoxazolone, 3-[(3-methoxyphenyl)methyl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)- Usage And Synthesis
UsesTNIK-IN-5 is an efficient TNIK inhibitor with IC50 of 0.05 μM. TNIK-IN-5 efficiently inhibits Wnt signaling in intact cells. TNIK-IN-5 shows excellent in vitro anti-colorectal cancer activity[1].
References[1] Luo X, Yang R, Li Y, Zhang L, Yang S, Li L. Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer. Bioorg Med Chem Lett. 2022;67:128745. DOI:10.1016/j.bmcl.2022.128745
2(3H)-Benzoxazolone, 3-[(3-methoxyphenyl)methyl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)- Preparation Products And Raw materials
Tag:2(3H)-Benzoxazolone, 3-[(3-methoxyphenyl)methyl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)-(2754265-66-0) Related Product Information
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