- TAT
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- $44.00 / 1mg
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2026-04-22
- CAS:191936-91-1
- Min. Order:
- Purity: 100.00%
- Supply Ability: 10g
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| | HIV-1 Tat Protein (47-57) Basic information |
| Product Name: | HIV-1 Tat Protein (47-57) | | Synonyms: | HIV-1 TAT PROTEIN (47-57);HIV-1 TAT PROTEIN PEPTIDE;H-TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG-OH;HIV-1 Tat (47-57);HIV-I TAT Protein Peptide;TAT (47-57);TYR-GLY-ARG-LYS-LYS-ARG-ARG-GLN-ARG-ARG-ARG;YGRKKRRQRRR | | CAS: | 191936-91-1 | | MF: | C64H118N32O14 | | MW: | 1559.83 | | EINECS: | | | Product Categories: | peptide | | Mol File: | 191936-91-1.mol |  |
| | HIV-1 Tat Protein (47-57) Chemical Properties |
| Melting point | 202-203 °C | | density | 1.54±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | deionized water: soluble | | form | lyophilized powder | | biological source | synthetic | | Water Solubility | deionized water: soluble | | Sequence | Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg | | InChIKey | RAVVEEJGALCVIN-AGVBWZICSA-N |
| | HIV-1 Tat Protein (47-57) Usage And Synthesis |
| Uses | TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can increase the yields and the solubility of heterologous proteins | | General Description | HIV-1 trans-activator of transcription (Tat) is an 11kDa protein, which regulates HIV-1 gene expression at the level of transcription and protein synthesis. It is located in the nucleus of infected cells. HIV-1 Tat functions as a transcriptional activator for the synthesis of full-length viral RNA. It induces RNA splicing. Tat is an RNA binding protein, which particularly recognizes trans activator response element (TAR) from the HIV-1 RNA molecule. | | Biochem/physiol Actions | Synthetic peptide that includes the sequence responsible for the cellular uptake of the human immunodeficiency virus-1 Tat protein, consisting of the polycationic region 49–57. The peptide is part of the protein transduction domain (PTD) and was shown to enable the introduction of nucleic acids into cells. | | IC 50 | HIV-1 | | References | [1] NICOLAS CHARNAY. Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein.[J]. ACS Applied Bio Materials, 2009: 74. DOI:10.1186/1742-4690-6-74.
[2] ASEN BAGASHEV Bassel E S. Roles and functions of HIV-1 Tat protein in the CNS: an overview.[J]. ACS Applied Energy Materials, 2013: 358. DOI:10.1186/1743-422X-10-358.
[3] NANCY MUELLER. The HIV-1 Tat Protein Enhances Splicing at the Major Splice Donor Site.[J]. ACS Applied Energy Materials, 2018. DOI:10.1128/JVI.01855-17.
[4] ESTEBAN CRUZ Veysel K. Synthesis and Enhanced Cellular Uptake In Vitro of Anti-HER2 Multifunctional Gold Nanoparticles.[J]. ACS Applied Energy Materials, 2019. DOI:10.3390/cancers11060870.
[5] ANDRé ZIEGLER Joachim S. Interaction of the protein transduction domain of HIV-1 TAT with heparan sulfate: binding mechanism and thermodynamic parameters.[J]. Biophysical journal, 2004, 86 1 Pt 1: 254-263. DOI:10.1016/S0006-3495(04)74101-6. |
| | HIV-1 Tat Protein (47-57) Preparation Products And Raw materials |
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