- Benzolamide
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- $47.00
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2026-07-27
- CAS:3368-13-6
- Purity: 99.31%
- Supply Ability: 10g
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| | Benzolamide Basic information |
| Product Name: | Benzolamide | | Synonyms: | 5-(phenylsulfonylamino)-1,3,4-thiadiazole-2-sulfonamide;2-benzenesulfonamido-1,3,4-thiadiazole-5-sulfonamide;Benzolamide;1,3,4-Thiadiazole-2-sulfonamide, 5-[(phenylsulfonyl)amino]-;5-(Phenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide;W 1803;W-1803;Benzolamide,Inhibitor,Carbonate dehydratase,seizures,CAS3,glaucoma,inhibit,Carbonic Anhydrase | | CAS: | 3368-13-6 | | MF: | C8H8N4O4S3 | | MW: | 320.37 | | EINECS: | | | Product Categories: | | | Mol File: | 3368-13-6.mol |  |
| | Benzolamide Chemical Properties |
| Melting point | 239.5°C (rough estimate) | | Boiling point | 585.9±33.0 °C(Predicted) | | density | 1.6772 (rough estimate) | | refractive index | 1.5690 (estimate) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 250 mg/mL (780.35 mM; Need ultrasonic) | | form | Solid | | pka | 4.42±0.40(Predicted) | | color | White to light yellow | | Water Solubility | 384.4mg/L(25 ºC) |
| | Benzolamide Usage And Synthesis |
| Uses | Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3]. | | in vivo | Benzolamide (90 μmol/kg; i.p.) decreases brain pH and suppresses electrographic post-asphyxia seizures in rats[3].
| Animal Model: | Male and female Wistar Han rats (11-day-old)[3] | | Dosage: | 90 μmol/kg | | Administration: | A single i.p. | | Result: | Induced a fast brain acidosis of a comparable magnitude.
Suppressed electrographic seizures after asphyxia by slowing down the recovery of brain pH. |
| | IC 50 | CA Ⅱ | | References | [1] Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1545-1554. DOI:10.1080/14756366.2020.1800670
[2] Vullo D, et, al. Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Molecules. 2020 Feb 25;25(5):1036. DOI:10.3390/molecules25051036
[3] Pospelov AS, et, al. Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia. Epilepsia. 2021 Jun 27. DOI:10.1111/epi.16963 |
| | Benzolamide Preparation Products And Raw materials |
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