2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylamino)-3-pyridinyl]-N2-[2-methoxy-5-methyl-4-(4-methyl-1-piperazinyl)phenyl]-

Request For Quotation
2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylamino)-3-pyridinyl]-N2-[2-methoxy-5-methyl-4-(4-methyl-1-piperazinyl)phenyl]- Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Company Name: Guangzhou Younan Technology Co., Ltd  
Tel: 020-82000279 18988941452
Email: YN_research@163.com
Company Name: Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd  
Tel: 15317229551
Email: 15151849396@163.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: Aikon International Limited  
Tel: 025-58859352 18651614124
Email: 2881516338@qq.com

2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylamino)-3-pyridinyl]-N2-[2-methoxy-5-methyl-4-(4-methyl-1-piperazinyl)phenyl]- manufacturers

  • TP-5801
  • TP-5801 pictures
  • $1400.00
  • 2026-07-15
  • CAS:2574474-81-8
  • Purity:
  • Supply Ability: 10g
2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylamino)-3-pyridinyl]-N2-[2-methoxy-5-methyl-4-(4-methyl-1-piperazinyl)phenyl]- Basic information
Product Name:2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylamino)-3-pyridinyl]-N2-[2-methoxy-5-methyl-4-(4-methyl-1-piperazinyl)phenyl]-
Synonyms:2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylamino)-3-pyridinyl]-N2-[2-methoxy-5-methyl-4-(4-methyl-1-piperazinyl)phenyl]-;TP-5801
CAS:2574474-81-8
MF:C24H31BrN8O
MW:527.46
EINECS:
Product Categories:
Mol File:2574474-81-8.mol
2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylamino)-3-pyridinyl]-N2-[2-methoxy-5-methyl-4-(4-methyl-1-piperazinyl)phenyl]- Structure
2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylamino)-3-pyridinyl]-N2-[2-methoxy-5-methyl-4-(4-methyl-1-piperazinyl)phenyl]- Chemical Properties
Boiling point 668.5±65.0 °C(Predicted)
density 1.391±0.06 g/cm3(Predicted)
pka7.75±0.42(Predicted)
form Solid
color Light yellow to green yellow
Safety Information
MSDS Information
2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylamino)-3-pyridinyl]-N2-[2-methoxy-5-methyl-4-(4-methyl-1-piperazinyl)phenyl]- Usage And Synthesis
UsesTP-5801 is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor (IC50=1.40 nM), and shows anti-tumor activity[1].
in vivo

TP-5801 (oral gavage; 10 mg/kg; once) treatment shows efficacy in the mouse survival model[1].
TP-5801 (oral gavage; 50 mg/kg; once daily; 7 d) treatment can inhibit localized tumor growth[1].

Animal Model:Female NOD/SCID mice injected with Ba/F3 luc cells expressing TNK1 AAA[1]
Dosage:10 mg/kg
Administration:Oral gavage; 10 mg/kg; once
Result:Showed no signs of toxicity and significantly prolonged lifespan.
Animal Model:NOD/SCID mice implanted subcutaneously with Ba/F3 luc cells expressing TNK1 AAA or BCR-ABL[1]
Dosage:50 mg/kg
Administration:Oral gavage; 50 mg/kg; once daily; 7 days
Result:Reduced phospho-STAT3 in TNK1-driven xenografts at 2hours post-treatment, and tumor burden in mice xenografted.
References[1] Tsz-Yin Chan, et al. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nat Commun. 2021 Sep 9;12(1):5337. DOI:10.1038/s41467-021-25622-3
2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylamino)-3-pyridinyl]-N2-[2-methoxy-5-methyl-4-(4-methyl-1-piperazinyl)phenyl]- Preparation Products And Raw materials
Tag:2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylamino)-3-pyridinyl]-N2-[2-methoxy-5-methyl-4-(4-methyl-1-piperazinyl)phenyl]-(2574474-81-8) Related Product Information
Anti-Aging Compound Library Protein Tyrosine Kinase Compound Library Anti-cancer compound library Glycodeoxycholic acid Homoharringtonine Ritlecitinib