Benzenepropanamide, α-[(5-chloro-2-hydroxybenzoyl)amino]-N-(4-chlorophenyl)-, (αS)-

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Benzenepropanamide, α-[(5-chloro-2-hydroxybenzoyl)amino]-N-(4-chlorophenyl)-, (αS)- manufacturers
Benzenepropanamide, α-[(5-chloro-2-hydroxybenzoyl)amino]-N-(4-chlorophenyl)-, (αS)- Basic information
Product Name:Benzenepropanamide, α-[(5-chloro-2-hydroxybenzoyl)amino]-N-(4-chlorophenyl)-, (αS)-
Synonyms:Benzenepropanamide, α-[(5-chloro-2-hydroxybenzoyl)amino]-N-(4-chlorophenyl)-, (αS)-;(S)-5-chloro-N-(1-((4-chlorophenyl)amino)-1-oxo-3-phenylpropan-2-yl)-2-hydroxybenzamide;(S)5chloroN(1((4chlorophenyl)amino)1oxo3phenylpropan2yl)2hydroxybenzamide,(S) 5 chloro N (1 ((4 chlorophenyl)amino) 1 oxo 3 phenylpropan 2 yl) 2 hydroxybenzamide;Anticancer agent 151;(S)-5-chloro-N-(1-((4-chlorophenyl)amino)-1-oxo-3-phenylpropan-2-yl)-2-hydroxybenzamide, 10 mM in DMSO
CAS:1227476-97-2
MF:C22H18Cl2N2O3
MW:429.3
EINECS:
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Mol File:1227476-97-2.mol
Benzenepropanamide, α-[(5-chloro-2-hydroxybenzoyl)amino]-N-(4-chlorophenyl)-, (αS)- Structure
Benzenepropanamide, α-[(5-chloro-2-hydroxybenzoyl)amino]-N-(4-chlorophenyl)-, (αS)- Chemical Properties
Melting point 236-238 °C
Boiling point 677.3±55.0 °C(Predicted)
density 1.397±0.06 g/cm3(Predicted)
pka7.77±0.43(Predicted)
Safety Information
MSDS Information
Benzenepropanamide, α-[(5-chloro-2-hydroxybenzoyl)amino]-N-(4-chlorophenyl)-, (αS)- Usage And Synthesis
UsesAnticancer agent 151 (compound 6C) is an anticancer agent. Anticancer agent 151 exhibits excellent in vitro cytotoxic activity against MCF-7 cells with an IC50 value of 6.3 μM[1].
References[1] Imramovsky A, et al. Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis incancer cell lines. Eur J Med Chem. 2013;68:253-259. DOI:10.1016/j.ejmech.2013.08.009
[2] Ale Imramovsky, et al. Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines. Eur J Med Chem. 2013. DOI:10.1016/j.ejmech.2013.08.009
Benzenepropanamide, α-[(5-chloro-2-hydroxybenzoyl)amino]-N-(4-chlorophenyl)-, (αS)- Preparation Products And Raw materials
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