艾默德斯
| 中文名称 | 艾默德斯 |
|---|---|
| 中文同义词 | 艾默德斯;EMODEPSIDE艾默德斯;哀默德斯;艾德甙;(3S,6R,9S,12R,15S,18R,21S,24R)-3,9,15,21-四异丁基-4,6,10,16,18,22-六甲基-12,24-双(4-吗啉苄基)-1,7,13,19-四氧杂-4,10,16,22-四氮杂环二十四烷-2,5,8,11,14,17,20,23-八酮;艾莫德丝;(3S,6R,9S,12R,15S,18R,21S,24R)-3,9,15,21-四异丁基-4,6,10,16,18,22-六甲基-12,24-双(4-吗啉苄基)-1,7,13,19-四氧杂-4,10,16,22-四氮杂环二十四烷-2,5,;艾莫德斯 |
| 英文名称 | Emodepside |
| 英文同义词 | Cyclo(.alpha.R)-.alpha.-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(.alpha.R)-.alpha.-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl;Emodepside;Cyclo(.alpha.R)-.alpha.-hydroxy-4-(4-morpholinyl)benzeneprop;QHT06;PF 1022-221;Bay 44-4400;Cyclo[(αR)-α-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl];(3S,6R,9S,12R,15S,18R,21S,24R)-3,9,15,21-tetraisobutyl-4,6,10,16,18,22-hexamethyl-12,24-bis(4-morpholinobenzyl)-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclotetracosan-2,5,8,11,14,17,20,23-octaone |
| CAS号 | 155030-63-0 |
| 分子式 | C60H90N6O14 |
| 分子量 | 1119.39 |
| EINECS号 | |
| 相关类别 | 科研原料;原料药;医用原料;生物化工;化学试剂;API;医药原料;科研精品试剂 |
| Mol文件 | 155030-63-0.mol |
| 结构式 |  |
艾默德斯 性质
| 沸点 | 1219.3±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.104±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥31mg/mL（27.69mM） |
| 酸度系数(pKa) | 5.34±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| InChIKey | ZMQMTKVVAMWKNY-FYSVEKGBNA-N |
| Target | Value |
|
Ca-dependent SLO-1-like K channels
() |
Emodepside is a semisynthetic derivative of PF1022A, which contains a morpholine attached in para position at each of both D-phenyllactic acids. Emodepside is efficacious against a variety of gastrointestinal nematodes. Emodepside binds to a presynaptic latrophilin receptor in nematodes. Emodepside produces a slow time-dependent (20 min), 4-aminopyridine sensitive, concentration-dependent hyperpolarization and increase in voltage-activated K currents. Emodepside has an inhibitory effect on spiking. Emodepside significantly inhibits the ryanodine increase in spike frequency between the 20 and 35 min period by 9.8 spikes/min. In the presence of emodepside, highly increased currents are observed without depolarization up to a threshold of 0 mV and without any additional stimuli to artificially increase [Ca 2+ ]i levels. These novel findings confirm that Slo-1 is a direct target of emodepside.
Emodepside interferes with signaling at the neuromuscular junction on the body-wall muscles, pharynx and egg-laying muscles and thus inhibits three important physiological functions: locomotion, feeding and reproduction.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 经口 生殖毒性 类别2 特异性靶器官毒性-反复接触类别2 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-101476 | 艾默德斯 Emodepside | 155030-63-0 | 1 mg | 636元 |
| 2025/12/22 | HY-101476 | 艾默德斯 Emodepside | 155030-63-0 | 5mg | 1400元 |