5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2)

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5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) Suppliers list
Company Name: Shandong Dayou Pharmaceutical Research and Development Co., Ltd.  
Tel: hanfangpharma@126.com 15165037910
Email: hanfangpharma@126.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) manufacturers
5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) Basic information
Product Name:5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2)
Synonyms:5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2);Syk Inhibitor II dihydrochloride dihydrate
CAS:1965323-05-0
MF:C14H18ClF3N6O2
MW:394.78
EINECS:
Product Categories:
Mol File:1965323-05-0.mol
5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) Structure
5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) Chemical Properties
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MSDS Information
5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) Usage And Synthesis
UsesSyk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect[1].
in vivo

Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride dihydrate is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg[1].

IC 50Syk: 41 nM (IC50); serotonin: 460 nM (IC50); PKCε: 5.1 μM (IC50); PKCβ2: 11 μM (IC50); ZAP-70: 11.2 μM (IC50); Btk: 15.5 μM (IC50); Itk: 22.6 μM (IC50)
References[1] Hiroyuki Hisamichi, et al. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51. DOI:10.1016/j.bmc.2005.05.033
5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2) Preparation Products And Raw materials
Tag:5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-, hydrochloride, hydrate (1:2:2)(1965323-05-0) Related Product Information
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